Not just amyloid: physiological functions of the amyloid precursor protein family

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The Cellular Phase of Alzheimer’s Disease

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

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Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

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Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus

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The role of protein clearance mechanisms in organismal ageing and age-related diseases

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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

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The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

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ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

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Molecular genetics of early-onset Alzheimer’s disease revisited

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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

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Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone

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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

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Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

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The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

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Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

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A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference

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Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

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Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

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Physiological Functions of APP Family ProteinsPreprint

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Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

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Homo‐ and heterodimerization of APP family members promotes intercellular adhesion

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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

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Adeno-Associated Virus-Based Gene Therapy for CNS Diseases

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Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease

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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSwMice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

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Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury

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Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

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Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

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Insights into the physiological function of the β‐amyloid precursor protein: beyond Alzheimer's disease

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Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory

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Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease.

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The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

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The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

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Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

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Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

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Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

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Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

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α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

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Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.

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Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

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The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

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Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

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The Proteolytic Processing of the Amyloid Precursor Protein Gene Family Members APLP-1 and APLP-2 Involves α-, β-, γ-, and ϵ-Like Cleavages

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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

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Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.

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Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing: Regulated intramembrane proteolysis and APP processing

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Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

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Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

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Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis

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A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

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Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

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Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

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Amyloid precursor protein (APP) regulates synaptic structure and function

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APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

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Regulation of spine morphology and spine density by NMDA receptor signaling in vivo

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The Amyloid Precursor Protein and Its Regulatory Protein, FE65, in Growth Cones and Synapses In Vitro and In Vivo

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A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

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Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

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Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

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Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats

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