Intracellular amyloid-β in Alzheimer's disease

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Items 701–800 of 1,005

1. Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions
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2. PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde
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3. Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis
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4. A specific RAGE-binding peptide biopanning from phage display random peptide library that ameliorates symptoms in amyloid β peptide-mediated neuronal disorder
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5. The Protective Effect of Antarctic Krill Oil on Cognitive Function by Inhibiting Oxidative Stress in the Brain of Senescence‐Accelerated Prone Mouse Strain 8 (SAMP8) Mice
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6. Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway
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7. Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative
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8. A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
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9. SUMOylation: Novel Neuroprotective Approach for Alzheimer’s Disease?
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10. Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers
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11. Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes
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12. Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration
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13. Dissecting Alzheimer disease in Down syndrome using mouse models
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14. CLPFFD–PEG functionalized NIR-absorbing hollow gold nanospheres and gold nanorods inhibit β-amyloid aggregation
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15. Aβ Seeding as a Tool to Study Cerebral Amyloidosis and Associated Pathology
    Marina Friesen, Melanie Meyer‐Luehmann · 2019 · Frontiers in Molecular Neuroscience
16. Telomere length associations with cognition depend on Alzheimer's disease biomarkers
    Emily R. Mahoney, Logan C. Dumitrescu, Mabel Seto, Kelly Nicole Holohan Nudelman, Rachel F. Buckley, Katie A. Gifford, Andrew J. Saykin, Angela Lee Jefferson, Timothy J. Hohman, Alzheimer’s Disease Neuroimaging Initiative · 2019 · Alzheimer s & Dementia Translational Research & Clinical Interventions
17. Identifying Fibrillization State of Aβ Protein via Near-Field THz Conductance Measurement
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18. Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity
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19. Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease
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20. Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease
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21. Optogenetics: implications for Alzheimer’s disease research and therapy
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22. Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response
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23. Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators?
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24. Structural Analysis Reveals an Amyloid Form of the Human Papillomavirus Type 16 E1 ∧ E4 Protein and Provides a Molecular Basis for Its Accumulation
    Pauline B. McIntosh, Stephen R. Martin, Deborah J. Jackson, Jameela Khan, Erin R. Isaacson, Lesley J. Calder, Kenneth Raj, Heather M. Griffin, Qian Wang, Peter Laskey et al. · 2008 · Journal of Virology
25. An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42
    Dafnis, Ioannis, Stratikos, Efstratios, Tzinia, Athina, Tsilibary, Effie C., Zannis, Vassilis I., Chroni, Angeliki · 2010 · Journal of Neurochemistry
26. Proanthocyanidins improves lead-induced cognitive impairments by blocking endoplasmic reticulum stress and nuclear factor-κB-mediated inflammatory pathways in rats
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27. Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood–Brain Barrier
    Corbin J. Bachmeier, David Beaulieu‐Abdelahad, Fiona Crawford, MICHAEL J. MULLAN, Daniel Paris · 2012 · Journal of Molecular Neuroscience
28. Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene Expression
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29. Binding studies of truncated variants of the Aβ peptide to the V-domain of the RAGE receptor reveal Aβ residues responsible for binding
    Emilia Gospodarska, Anna Kupniewska-Kozak, Grażyna Goch, Michał Dadlez · 2011 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
30. Roles of Meltrin-β/ADAM19 in Progression of Schwann Cell Differentiation and Myelination during Sciatic Nerve Regeneration
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31. Is Abnormal Axonal Transport a Cause, a Contributing Factor or a Consequence of the Neuronal Pathology in Alzheimer‘s Disease?
    Virgil Mureşan, Zoia Ladescu Muresan · 2009 · Future Neurology
32. The multifaceted role of metalloproteinases in physiological and pathological conditions in embryonic and adult brains
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33. Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety
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34. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway
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35. Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice
    Eun-Jeong Yang, Usman Mahmood, Hyun-Ju Kim, Moonseok Choi, Yunjung Choi, Jean‐Pyo Lee, Joo‐Youn Cho, Jin Won Hyun, Yong Sik Kim, Moon‐Jeong Chang et al. · 2018 · Free Radical Biology and Medicine
36. Bridging the Gap Between Fluid Biomarkers for Alzheimer’s Disease, Model Systems, and Patients
    Christiana Bjorkli, Axel Sandvig, Ioanna Sandvig · 2020 · Frontiers in Aging Neuroscience
37. Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies
    Jangampalli Adi Pradeepkiran, P. Hemachandra Reddy · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
38. RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity
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39. Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function
    Tobias Huth, Karoline Schmidt-Neuenfeldt, Andrea Rittger, Paul Säftig, Karina Reiß, Christian Alzheimer · 2008 · Neurobiology of Disease
40. β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides
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41. Insulin Signaling in Sporadic Alzheimer’s Disease
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42. Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: Deficit in memory retrieval associated with increased sensitivity to interference?
    Stéphanie Daumas, Johan Sandin, Karen S Chen, Dione T. Kobayashi, Jane Tulloch, Stephen J. Martin, Dora Games, Richard Morris · 2008 · Learning & Memory
43. A partial reduction of <scp>VDAC1</scp> enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
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44. Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation State
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45. The exploration of thienothiazines as selective butyrylcholinesterase inhibitors
    Daniela Karlsson, Adyary Fallarero, Gerda Brunhofer, Claudia Mayer, Ohm Prakash, C. Gopi Mohan, Pia Maarit Vuorela, Thomas Erker · 2012 · European Journal of Pharmaceutical Sciences
46. Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in Alzheimer's Disease Models
    Siva Sundara Kumar Durairajan, Yingyu Huang, Pui-Yee Yuen, Leilei Chen, Ka-Yan Kwok, Liang‐Feng Liu, Ju‐Xian Song, Quan‐Bin Han, Lei Xue, Sookja Kim Chung et al. · 2014 · PLoS ONE
47. Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus
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48. Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer′s disease story?
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49. Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice
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50. Cholinergic Mechanisms in the Cerebral Cortex
    Saak Victor Ovsepian, Valerie B. O’Leary, László Záborszky · 2015 · The Neuroscientist
51. Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model
    Jingfei Chen, Zhimin Long, Yanzhen Li, Min Luo, Shifang Luo, Guiqiong He · 2019 · International Journal of Molecular Medicine
52. The Tryptophan Catabolite or Kynurenine Pathway in Alzheimer’s Disease: A Systematic Review and Meta-Analysis
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53. AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease
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54. Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the APP/PS1 Alzheimer’s disease mouse model by regulating the expression of APP secretases
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55. Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases
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56. Oxidative damage and amyloid‐β metabolism in brain regions of the longest‐lived rodents
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57. Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem Cells
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58. Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons
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59. Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease
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60. Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C
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61. Amyloid β Fibril Elongation by Monomers Involves Disorder at the Tip
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63. Mitochondrial accumulation of amyloid β (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast
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64. Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging
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65. Cyanidin-3- O -glucoside inhibits Aβ40 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity
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66. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA
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67. Optimization of hydrolysis conditions, isolation, and identification of neuroprotective peptides derived from seahorse Hippocampus trimaculatus
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68. Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?
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69. Hemicyanine-based fluorescent probes: Advancements in biomedical sensing and activity-based detection
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70. Quality Control Compartments Coming of Age
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71. Yeast as a Model System to Study Tau Biology
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72. Intracellular Amyloid Precursor Protein Sorting and Amyloid- Secretion Are Regulated by Src-Mediated Phosphorylation of Mint2
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73. The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
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74. Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease
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75. Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer’s disease
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76. The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
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77. Recent Insights on Alzheimer’s Disease Originating from Yeast Models
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78. Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid-predominant mouse model of Alzheimer's disease
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79. Endosomal dysfunction impacts extracellular vesicle release: Central role in Aβ pathology
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80. Effect of Aβ Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons
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81. Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro
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82. Brain Microvascular Endothelial Cell Derived Exosomes Potently Ameliorate Cognitive Dysfunction by Enhancing the Clearance of Aβ Through Up-Regulation of P-gp in Mouse Model of AD
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83. Advances on the Understanding of the Origins of Synaptic Pathology in AD
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84. Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
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85. β‐Amyloid pathogenesis: Chemical properties versus cellular levels
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86. Anti-amyloid-beta to tau-based immunization: developments in immunotherapy for Alzheimer's disease
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87. Iron increases APP translation and amyloid-beta production in the retina
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88. Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment
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89. Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
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90. Size-Dependent Interaction of Amyloid β Oligomers with Brain Total Lipid Extract Bilayer─Fibrillation Versus Membrane Destruction
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91. Human Amylin: From Pathology to Physiology and Pharmacology
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92. Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization
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93. Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers
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94. Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats
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95. Beta-Amyloid Oligomers Activate Apoptotic BAK Pore for Cytochrome c Release
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96. Single Molecule Tracking Analysis Reveals That the Surface Mobility of Amyloid Oligomers Is Driven by Their Conformational Structure
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97. The Role of Oxidative Stress in Neurodegenerative Diseases
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98. Mitochondrial Toxic Effects of Aβ Through Mitofusins in the Early Pathogenesis of Alzheimer’s Disease
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99. Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila
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100. Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease
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