The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Open accessAbstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
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“Conversely, in PD, the early and preferential loss of DA in the dorsal basal ganglia leads to diminished automatic and increased cognitive (frontal cortex) control of motor movements.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
In the citing paper
“Consequently, individuals with PD must handle and sustain a larger cognitive load to execute either motor or cognitive tasks2, 3.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
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“In healthy individuals, motor performance is dependent on the interaction between unconscious (automatic) and volitional (cognitive) control of movement 1, 2.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
In the citing paper
“The basal ganglia and its cortical connections also play an essential role in procedural motor learning, including the acquisition and retention of automaticity (For review see 2, 127).”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
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Citations
Cites
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Cited by
Sorted by citations
Direct and indirect pathways of basal ganglia: a critical reappraisal
Calabresi, P., Picconi, B., Tozzi, A., Ghiglieri, V., & Filippo, M. D. (2014) · Nature Neuroscience · doi:10.1038/nn.3743 · Cited by 820
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
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A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
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Metadata
- Authors
- Redgrave, P., Rodriguez, M., Smith, Y., Rodriguez-Oroz, M. C., Lehericy, S., Bergman, H., Agid, Y., DeLong, M. R., & Obeso, J. A.
- Affiliations
- University of Sheffield (GB)
- Emory University (US)
- Hebrew University of Jerusalem (IL)
- Institut du Cerveau (FR)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Corresponding author
- Redgrave, Peter
- Obeso, Jose A.
- Venue
- Nature reviews. Neuroscience
- Published
- 2010-10-14
- Volume
- 11
- Issue
- 11
- Pages
- 760-772
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3124757
- OpenAlex
- W2056061278
- Cited by
- 1,134
- References
- 178
- Citations by year
- 2026: 59 · 2025: 78 · 2024: 74 · 2023: 70 · 2022: 90 · 2021: 78 · 2020: 75 · 2019: 122 · 2018: 64 · 2017: 62 · 2016: 73 · 2015: 65 · 2014: 72 · 2013: 68 · 2012: 47
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (091409)
- Universidad de Navarra
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- basal ganglia, Parkinson's disease, goal-directed behavior, habitual behavior, dopamine depletion, posterior putamen, action control
- MeSH terms
- Animals, Basal Ganglia, Goals, Habituation, Psychophysiologic, Humans, Models, Neurological, Nerve Net, Neural Pathways, Parkinson Disease
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