The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Open accessAbstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Conversely, in PD, the early and preferential loss of DA in the dorsal basal ganglia leads to diminished automatic and increased cognitive (frontal cortex) control of motor movements.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
In the citing paper
“Consequently, individuals with PD must handle and sustain a larger cognitive load to execute either motor or cognitive tasks2, 3.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
In the citing paper
“In healthy individuals, motor performance is dependent on the interaction between unconscious (automatic) and volitional (cognitive) control of movement 1, 2.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
In the citing paper
“The basal ganglia and its cortical connections also play an essential role in procedural motor learning, including the acquisition and retention of automaticity (For review see 2, 127).”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · cited 1×
“Accordingly, the direct projections between the striatum and the basal ganglia output nuclei represent the internal component of the general, partially segregated, looped architecture that connects the basal ganglia with extrinsic cortica”
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353 · cited 1×
“The activity of striatal medium spiny projection neurons is conveyed to the output nuclei (GPi and SNr) through a monosynaptic GABA (γ-aminobutyric acid)-ergic projection (the 'direct' pathway) and a polysynaptic ('indirect') pathway that involves relays in the external globus pallidus (GPe) and the subthalamic nucleu…”
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
The Handbook of brain theory and neural networks
(1996) · Choice Reviews Online · doi:10.5860/choice.33-4484 · Cited by 3,913
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824 · cited 1×
“Consequently, according to this model, in the normal state, activation of the 'indirect circuits' at the level of the striatum would promote movement inhibition or arrest, whereas activation of the 'direct circuit' would facilitate movemen”
Frequency Dependence of Signal Power and Spatial Reach of the Local Field Potential
Leski, S., Lindén, H., Tetzlaff, T., Pettersen, K. H., & Einevoll, G. T. (2013) · PubMed · doi:10.18154/rwth-conv-084442 · Cited by 3,667
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · cited 1×
“However, sensory input is equally important for goal-directed contro”
Monsell, S. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(03)00028-7 · Cited by 2,984
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · cited 1×
“In the parkinsonian state , reduced dopamine input from the SNc to the striatum would have a dual effect, facilitating neurons that give rise to the 'indirect' projection and reducing the activation of 'direct pathway' neuron”
Daw, N. D., Niv, Y., & Dayan, P. (2005) · Nature Neuroscience · doi:10.1038/nn1560 · Cited by 2,533 · cited 1×
“Nevertheless, a fundamental problem remains: at any point in time, which mode should be allowed to control which component of a task? Daw et al”
THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS
Mink, J. W. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00042-1 · Cited by 2,478 · cited 1×
“Tonic firing is essential for normal 'selective functions' of the basal gangli”
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129 · cited 1×
“However, such movements commonly reflect the expression of classically conditioned reflexes associated more with cerebellar and limbic circuitr”
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945
Advances in Neural Information Processing Systems 18
Murray, I., Mackay, D., Zoubin Ghahramani, A., & Skilling, J. (2006) · Cited by 1,927
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · cited 1×
“The ascending dopaminergic systems have both tonic and phasic patterns of activit”
A neostriatal habit learning system in humans
Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777 · cited 1×
“and are impaired in their implicit learning of habit”
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777 · cited 1×
“The projection from the SNc and the ventral tegmental area targets all intrinsic nuclei of the basal ganglia but with preferential concentrations of terminals in the dorsal and ventral striatu”
Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775
Habits, Rituals, and the Evaluative Brain
Graybiel, A. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112851 · Cited by 1,697 · cited 1×
“It is therefore possible that conflict-induced habit formation may be different from that induced by extensive training (which results in quicker habitual responding”
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637 · cited 1×
“, whereas sensory-evoked phasic activity provides 'teaching signals' for instrumental learning”
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · cited 1×
“Under these conditions decreased responding would reflect goal-directed control of behaviour, whereas maintained responding would reflect habitual control of behaviou”
The primate basal ganglia: Parallel and integrative networks
Haber, S. N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.003 · Cited by 1,479
Behavior Theory and Conditioning
Bitterman, M. E., & Spence, K. W. (1957) · The American Journal of Psychology · doi:10.2307/1419251 · Cited by 1,460
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells
Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385
Functional significance of the cortico-subthalamo-pallidal “hyperdirect” pathway
Nambu, A., Tokuno, H., & Takada, M. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00027-5 · Cited by 1,371
The organization of the projection from the cerebral cortex to the striatum in the rat
McGeorge, A. J., & Faull, R. L. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90128-0 · Cited by 1,360 · cited 1×
“A widely recognized feature of connections between the intrinsic nuclei of the basal ganglia is their high degree of spatial topograph”
Role of the Basal Ganglia in the Control of Purposive Saccadic Eye Movements
Hikosaka, O., Takikawa, Y., & Kawagoe, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.953 · Cited by 1,334 · cited 1×
“Tonic firing is essential for normal 'selective functions' of the basal gangli”
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226
The basal ganglia: a vertebrate solution to the selection problem?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00319-4 · Cited by 1,199
Putting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188
Wilson, S. A. K. (1912) · Brain · doi:10.1093/brain/34.4.295 · Cited by 1,136
Tonic dopamine: Opportunity costs and the control of response vigor
Niv, Y., Daw, N. D., Joel, D., & Dayan, P. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0502-4 · Cited by 1,133
The role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099
Circuits and Circuit Disorders of the Basal Ganglia
DeLong, M. R., & Wichmann, T. (2007) · Archives of Neurology · doi:10.1001/archneur.64.1.20 · Cited by 1,074 · cited 1×
“Many experimental investigations have shown that basal ganglia output is abnormal in patients with Parkinson's disease and in animal models of the diseas”
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051
Motivational control of goal-directed action
Dickinson, A., & Balleine, B. (1994) · Animal Learning & Behavior · doi:10.3758/bf03199951 · Cited by 995 · cited 1×
“However, during the past 20 years it has become clear that animals can also encode causal relationships between actions and outcome”
Disinhibition as a basic process in the expression of striatal functions.
Chevalier, G., & Deniau, J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90109-n · Cited by 965 · cited 1×
“Output from GABAergic GPi and SNr neurons keep targeted structures in the thalamus and brainstem under tonic inhibitory control: this tonic inhibition is blocked (that is, paused) by phasic inhibitory signals from the 'direct' striato–nigral-pallidal projectio”
Smith, Y., Bevan, M. D., Shink, É., & Bolam, J. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00004-9 · Cited by 961
Monchi, O., Petrides, M., Petre, V., Worsley, K., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07733.2001 · Cited by 961 · cited 1×
“In humans, blood oxygen level-dependent (BOLD) activation of the caudate nucleus and the regions of the prefrontal cortex associated with it occurs during goal-directed behaviours, such as set shifting”
The mysterious motor function of the basal ganglia
MARSDEN, C. D. (1982) · Neurology · doi:10.1212/wnl.32.5.514 · Cited by 924 · cited 1×
“Thus, dysfunction of basal ganglia sensorimotor circuits marks the initial stages of Parkinson's diseas”
Alexander, G. E. (1998) · Cited by 891
Ferrier, D. (1876) · G P Putnam's Sons eBooks · doi:10.1037/12860-000 · Cited by 872
Behavior theory and conditioning.
Spence, K. W. (1956) · doi:10.1037/10029-000 · Cited by 872 · cited 1×
“Early analyses of instrumental behaviour stressed the importance of reinforced associations between stimuli and response”
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
Rodríguez‐Oroz, M., Jahanshahi, M., Krack, P., Litvan, I., Macías, R. J., Bézard, E., & Obeso, J. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70293-5 · Cited by 866 · cited 1×
“Thus, dysfunction of basal ganglia sensorimotor circuits marks the initial stages of Parkinson's diseas”
Matsuda, W., Furuta, T., Nakamura, K. C., Hioki, H., Fujiyama, F., Arai, R., & Kaneko, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4029-08.2009 · Cited by 865 · cited 1×
“The main nigrostriatal projection maintains a general medial to lateral topograph”
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858
Controlled & automatic processing: behavior, theory, and biological mechanisms
Schneider, W., & Chein, J. M. (2003) · Cognitive Science · doi:10.1207/s15516709cog2703_8 · Cited by 795
A specific role for posterior dorsolateral striatum in human habit learning
Tricomi, E., Balleine, B. W., & O’Doherty, J. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06796.x · Cited by 769 · cited 1×
“By contrast, the caudal putamen was preferentially activated during an outcome devaluation test when subjects' behavioural responses were habitua”
The short-latency dopamine signal: a role in discovering novel actions?
Redgrave, P., & Gurney, K. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2022 · Cited by 762 · cited 1×
“, whereas sensory-evoked phasic activity provides 'teaching signals' for instrumental learning”
The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease
Marsden, C. D., & Obeso, J. A. (1994) · Brain · doi:10.1093/brain/117.4.877 · Cited by 718
Instrumental Responding following Reinforcer Devaluation
Adams, C. D., & Dickinson, A. (1981) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748108400816 · Cited by 687
The Neuroscience of Mammalian Associative Learning
Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683 · cited 1×
“However, such movements commonly reflect the expression of classically conditioned reflexes associated more with cerebellar and limbic circuitr”
Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism
Filion, M., & Tremblay, L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90585-j · Cited by 641 · cited 1×
“Typically, neurons in the STN and GPi show increased firin”
Distinct basal ganglia territories are engaged in early and advanced motor sequence learning
Lehéricy, S., Benali, H., Van de Moortele, P.-F., Pélégrini-Issac, M., Waechter, T., Ugurbil, K., & Doyon, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502762102 · Cited by 634 · cited 1×
“During prolonged training on motor tasks (when performance would be expected to shift from being under goal-directed to being under habitual control), the activation pattern gradually shifts from rostromedial (associative) to caudolateral (sensorimotor) regions of the striatu”
Self-citationA computational model of action selection in the basal ganglia. I. A new functional anatomy
GURNEY, K. N., Prescott, T. J., & Redgrave, P. (2001) · Biological Cybernetics · doi:10.1007/pl00007984 · Cited by 633 · cited 1×
“— results in effective action selection, in computational model”
A PHYSIOLOGICAL MECHANISM OF BRADYKINESIA
Hallett, M., & Khoshbin, S. (1980) · Brain · doi:10.1093/brain/103.2.301 · Cited by 632 · cited 1×
“This idea would also explain many features of bradykinesia, like reduced amplitude of agonist muscle recruitment of a ballistic movement and rapid decline of repetitive movement”
Functional properties of monkey caudate neurons. I. Activities related to saccadic eye movements
Hikosaka, O., Sakamoto, M., & Usui, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.780 · Cited by 533
YIN, H., KNOWLTON, B., & BALLEINE, B. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.012 · Cited by 532
[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].
Birkmayer, W., & Hornykiewicz, O. (1961) · PubMed · Cited by 532
Functional diversity and specificity of neostriatal interneurons
Tepper, J. M., & Bolam, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.003 · Cited by 526
DISTURBANCE OF SEQUENTIAL MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
Benecke, R., Rothwell, J. C., Dick, J., Day, B. L., & MARSDEN, C. D. (1987) · Brain · doi:10.1093/brain/110.2.361 · Cited by 514 · cited 1×
“Therefore, if our proposal that patients with Parkinson's disease increasingly have to operate in goal-directed control mode is correct, this could explain why they have particular problems with the automatic components of action sequence”
Rodríguez‐Oroz, M. (2001) · Brain · doi:10.1093/brain/124.9.1777 · Cited by 468
Anatomy of Motor Learning. II. Subcortical Structures and Learning by Trial and Error
Jueptner, M., Frith, C., Brooks, D. J., Frackowiak, R. S. J., & Passingham, R. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.3.1325 · Cited by 466 · cited 1×
“During prolonged training on motor tasks (when performance would be expected to shift from being under goal-directed to being under habitual control), the activation pattern gradually shifts from rostromedial (associative) to caudolateral (sensorimotor) regions of the striatu”
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04219.x · Cited by 447
Subcortical loops through the basal ganglia
McHaffie, J. G., Stanford, T. R., Stein, B. E., Coizet, V., & Redgrave, P. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.006 · Cited by 430
Monakow, K. H.-V., Akert, K., & K�nzle, H. (1978) · Experimental Brain Research · doi:10.1007/bf00235561 · Cited by 425
Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
Faure, A., Haberland, U., Condé, F., & Massioui, N. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3894-04.2005 · Cited by 402 · cited 1×
“Here, selective loss of dopamine from the lateral SNc and lateral striatum caused behaviour to remain goal-directed, despite over-training, whereas control animals showed normal habit developmen”
López‐Azcárate, J., Tainta, M., Rodríguez-Oroz, M. C., Valencia, M., Gonzalez-Redondo, R., Guridi, J., Iriarte, J., Obeso, J. A., Artieda, J., & Alegre, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5459-09.2010 · Cited by 396 · cited 1×
“and abnormal patterns of synchronised oscillations”
PERFORMANCE OF SIMULTANEOUS MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
Benecke, R., Rothwell, J. C., Dick, J., Day, B. L., & MARSDEN, C. D. (1986) · Brain · doi:10.1093/brain/109.4.739 · Cited by 383 · cited 1×
“Thus, a gradual replacement of automatic control by effortful, goal-directed processing in patients with Parkinson's disease should render their task in hand increasingly subject to interference from other goal-directed task”
Functional role of the basal ganglia in the planning and execution of actions
Monchi, O., Petrides, M., Strafella, A. P., Worsley, K. J., & Doyon, J. (2006) · Annals of Neurology · doi:10.1002/ana.20742 · Cited by 381
A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia
Humphries, M. D., Stewart, R. D., & GURNEY, K. N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3486-06.2006 · Cited by 379 · cited 1×
“— results in effective action selection, in computational model”
Differential roles of monkey striatum in learning of sequential hand movement
Miyachi, S., Hikosaka, O., Miyashita, K., Kárádi, Z., & Rand, M. K. (1997) · Experimental Brain Research · doi:10.1007/pl00005669 · Cited by 374
Bevan, M. D., Booth, P. A. C., Eaton, S. A., & Bolam, J. P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09438.1998 · Cited by 373
The history of dopamine and levodopa in the treatment of Parkinson's disease
Fahn, S. (2008) · Movement Disorders · doi:10.1002/mds.22028 · Cited by 369
Voon, V., Fernagut, P., Wickens, J. R., Baunez, C., Rodríguez-Oroz, M. C., Pavon, N., Juncos, J. L., Obeso, J. A., & Bézard, E. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70287-x · Cited by 365 · cited 1×
“Although we have concentrated on goal-directed and habitual control by the basal ganglia, to ignore influences of the mesolimbic territories on the behaviour of patients with Parkinson's disease would be a mistake (see Ref”
Brown, P., & MARSDEN, C. D. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11225-9 · Cited by 364
The basal ganglia in Parkinson's disease: Current concepts and unexplained observations
Obeso, J. A., Marin, C., Rodriguez-Oroz, C., Blesa, J., Benitez-Temiño, B., Mena-Segovia, J., Rodríguez, M., & Olanow, C. W. (2009) · Annals of Neurology · doi:10.1002/ana.21481 · Cited by 359 · cited 1×
“Many experimental investigations have shown that basal ganglia output is abnormal in patients with Parkinson's disease and in animal models of the diseas”
The integrative function of the basal ganglia in instrumental conditioning
Balleine, B. W., Liljeholm, M., & Ostlund, S. B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.034 · Cited by 356
Sommer, M. A., & Wurtz, R. H. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.1979 · Cited by 355 · cited 1×
“and also by inputs from higher-level structures that are involved in goal-directed contro”
Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?
Mena‐Segovia, J., Bolam, J. P., & Magill, P. J. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.009 · Cited by 349
Flaherty, A. W., & Graybiel, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01120.1993 · Cited by 338
The effect of the instrumental training contingency on susceptibility to reinforcer devaluation
Dickinson, A., Nicholas, D. J., & Adams, C. D. (1983) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748308400912 · Cited by 338 · cited 1×
“By contrast, interval schedules (for example, schedules in which the first response following a specified period is rewarded) facilitate habitual responding because contingencies between action and outcome are variabl”
Alexander, G. E., & DeLong, M. R. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.6.1417 · Cited by 336
Behavioural assessment of mice lacking D1A dopamine receptors
Smith, D., Striplin, C. D., Geller, A. M., Mailman, R. B., Drago, J., Lawler, C. P., & Gallagher, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00608-8 · Cited by 334
Brainstem projections to midline and intralaminar thalamic nuclei of the rat
Krout, K. E., Belzer, R. E., & Loewy, A. D. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10236 · Cited by 328 · cited 1×
“Indeed, there is a phylogenetically older set of closed-loop subcortical connections between the basal ganglia and brainstem sensorimotor structures, which include the superior and inferior collicul”
Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms
Hikosaka, O., & Isoda, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.006 · Cited by 325 · cited 1×
“However, if something unexpected occurs, such as someone stepping out into the road, there is an immediate switch from habitual to goal-directed contro”
Striatal inhomogeneities and basal ganglia function
Penney, J. B., & Young, A. B. (1986) · Movement Disorders · doi:10.1002/mds.870010102 · Cited by 321
Vitek, J. L., Bakay, R. A. E., Hashimoto, T., Kaneoke, Y., Mewes, K., Zhang, J. Y., Rye, D. B., Starr, P. A., Baron, M. S., Turner, R., et al. (1998) · Journal of neurosurgery · doi:10.3171/jns.1998.88.6.1027 · Cited by 321 · cited 1×
“In this context, it is worth pointing out that the most beneficial therapeutic results are achieved when inactivating treatments are directed to the sensorimotor — as opposed to the limbic or associative — territories of relevant basal ganglia nucle”
Functional properties of monkey caudate neurons. II. Visual and auditory responses
Hikosaka, O., Sakamoto, M., & Usui, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.799 · Cited by 319
Motor learning in Parkinson's disease: limitations and potential for rehabilitation
Nieuwboer, A., Rochester, L., Münks, L., & Swinnen, S. P. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70781-3 · Cited by 315 · cited 1×
“Thus, a gradual replacement of automatic control by effortful, goal-directed processing in patients with Parkinson's disease should render their task in hand increasingly subject to interference from other goal-directed task”
Lehéricy, S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh091 · Cited by 311
GURNEY, K. N., Prescott, T. J., & Redgrave, P. (2001) · Biological Cybernetics · doi:10.1007/pl00007985 · Cited by 301
Matamales, M., Bertran‐Gonzalez, J., Salomon, L., Degos, B., Deniau, J., Valjent, E., Hervé, D., & Girault, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004770 · Cited by 300 · cited 1×
“First, an additional feature of the 'direct' pathway from the striatum to the output nuclei is the branching collateral fibres that terminate sparsely in GP”
Carpenter, M. B., Whittier, J. R., & Mettler, F. A. (1950) · The Journal of Comparative Neurology · doi:10.1002/cne.900920303 · Cited by 297
Shink, É., Bevan, M. D., Bolam, J. P., & Smith, Y. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00022-x · Cited by 296
Crossman, A. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90322-8 · Cited by 294
THE EFFECT OF CONTINGENCY UPON THE APPETITIVE CONDITIONING OF FREE‐OPERANT BEHAVIOR
Hammond, L. J. (1980) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1980.34-297 · Cited by 291 · cited 1×
“A second test involves degrading the contingency relationship between action and outcom”
Levy, R., Hutchison, W. D., Lozano, A. M., & Dostrovsky, J. O. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02855.2002 · Cited by 290 · cited 1×
“and abnormal patterns of synchronised oscillations”
Memory formation under stress: Quantity and quality
Schwabe, L., Wolf, O. T., & Oitzl, M. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.015 · Cited by 289 · cited 1×
“Once habits are established, habitual responding tends to dominate, especially in stressful situations in which quick reactions are require”
Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
Lewis, S. J. G., Dove, A., Robbins, T. W., Barker, R. A., & Owen, A. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03108.x · Cited by 278
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum
Tremblay, L., Hollerman, J. R., & Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.964 · Cited by 273 · cited 1×
“Functional divisions of the basal ganglia Micro-stimulation and micro-recording investigations in behaving monkey”
Nandhagopal, R., Kuramoto, L., Schulzer, M., Mak, E., Cragg, J. J., Lee, C. S., McKenzie, J., McCormick, S., Samii, A., Troiano, A. R., et al. (2009) · Brain · doi:10.1093/brain/awp209 · Cited by 270 · cited 1×
“In most cases, however, it is unclear whether these deficits reflect a partial, disease-related loss of dopaminergic input to associative territories of the striatu”
Calculating Consequences: Brain Systems That Encode the Causal Effects of Actions
Tanaka, S. C., Balleine, B. W., & O'Doherty, J. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1808-08.2008 · Cited by 268
Miyachi, S., Hikosaka, O., & Lu, X. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1213-7 · Cited by 262
What is reinforced by phasic dopamine signals?
Redgrave, P., GURNEY, K. N., & Reynolds, J. N. J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.007 · Cited by 261 · cited 1×
“, whereas sensory-evoked phasic activity provides 'teaching signals' for instrumental learning”
Neural circuits and functional organization of the striatum
Nakano, K., Kayahara, T., Tsutsumi, T., & Ushiro, H. (2000) · Journal of Neurology · doi:10.1007/pl00007778 · Cited by 250 · cited 1×
“Thus, in primates, projections from the striatum to the globus pallidus and substantia nigra maintain a general arrangement throughout the different intrinsic nuclei, whereby the posterior putamen is engaged in sensorimotor functions, the caudate and anterior putamen in associative functions, and the ventral (limbic)…”
Clinical and [18F] dopa PET findings in early Parkinson's disease.
Morrish, P., Sawle, G. V., & Brooks, D. J. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.59.6.597 · Cited by 244 · cited 1×
“Indeed, positron emission tomography (PET) imaging typically reveals reduced levels of 18 fluorodopa uptake mainly in caudal regions of the striatu”
Globus pallidus external segment
Kita, H. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)60007-1 · Cited by 228
Behaviorally contingent property of movement-related activity of the primate putamen
Kimura, M. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.6.1277 · Cited by 226 · cited 1×
“Functional divisions of the basal ganglia Micro-stimulation and micro-recording investigations in behaving monkey”
Compston, A. (2009) · Brain · doi:10.1093/brain/awp193 · Cited by 220
Jahanshahi, M., Brown, R. G., & MARSDEN, D. (1992) · Brain · doi:10.1093/brain/115.2.539 · Cited by 214 · cited 1×
“A second objection could be that patients with Parkinson's disease show an improvement in motor performance when they are guided by sensory stimul”
Wu, Y., Richard, S., & Parent, A. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00140-1 · Cited by 213 · cited 1×
“First, an additional feature of the 'direct' pathway from the striatum to the output nuclei is the branching collateral fibres that terminate sparsely in GP”
Wichmann, T., & Soares, J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01013.2005 · Cited by 211 · cited 1×
“and abnormal patterns of synchronised oscillations”
Motor sequence learning and movement disorders
Doyon, J. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328304b6a3 · Cited by 194 · cited 1×
“Therefore, if our proposal that patients with Parkinson's disease increasingly have to operate in goal-directed control mode is correct, this could explain why they have particular problems with the automatic components of action sequence”
CONTROL OF TWO SIMULTANEOUS VOLUNTARY MOTOR ACTS IN NORMALS AND IN PARKINSONISM
Schwab, R. S. (1954) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1954.02330050061010 · Cited by 191
HEMICHOREA RESULTING FROM A LOCAL LESION OF THE BRAIN. (THE SYNDROME OF THE BODY OF LUYS
MARTIN, J. P. (1927) · Brain · doi:10.1093/brain/50.3-4.637 · Cited by 190
Periaqueductal gray matter projections to midline and intralaminar thalamic nuclei of the rat
Krout, K. E., & Loewy, A. D. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000814)424:1 · Cited by 189
The 28th Bartlett Memorial Lecture Causal learning: An associative analysis
Dickinson, A. (2001) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990042000010 · Cited by 187
MOVEMENT PREPARATION IN PARKINSON'S DISEASE
Stelmach, G. E., Worringham, C. J., & Strand, E. A. (1986) · Brain · doi:10.1093/brain/109.6.1179 · Cited by 186 · cited 1×
“Therefore, if our proposal that patients with Parkinson's disease increasingly have to operate in goal-directed control mode is correct, this could explain why they have particular problems with the automatic components of action sequence”
Still at the Choice‐Point: Action Selection and Initiation in Instrumental Conditioning
BALLEINE, B. W., & OSTLUND, S. B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.006 · Cited by 184
A robot model of the basal ganglia: Behavior and intrinsic processing
Prescott, T. J., Montes-González, F., GURNEY, K. N., Humphries, M. D., & Redgrave, P. (2005) · Neural Networks · doi:10.1016/j.neunet.2005.06.049 · Cited by 182
Féger, J., Bevan, M. D., & Crossman, A. R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90208-9 · Cited by 176
Subthalamic nucleus and its connections
Benarroch, E. E. (2008) · Neurology · doi:10.1212/01.wnl.0000313022.39329.65 · Cited by 176
Romanelli, P., Esposito, V., Schaal, D. W., & Heit, G. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.09.008 · Cited by 168 · cited 1×
“A widely recognized feature of connections between the intrinsic nuclei of the basal ganglia is their high degree of spatial topograph”
Neural circuits and topographic organization of the basal ganglia and related regions
Nakano, K. (2000) · Brain and Development · doi:10.1016/s0387-7604(00)00139-x · Cited by 164
Striatal control of locomotion, intentional actions and of integrating and perceptive activity
Hassler, R. G. (1978) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(78)90082-5 · Cited by 150
Synaptic release of dopamine in the subthalamic nucleus
Cragg, S. J., Baufreton, J., Xue, Y., Bolam, J. P., & Bevan, M. D. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03629.x · Cited by 145
Foot, Hand, Face and Eye Representation in the Human Striatum
Gérardin, E. (2002) · Cerebral Cortex · doi:10.1093/cercor/13.2.162 · Cited by 144
Gitelman, D. R., Parrish, T. B., Friston, K. J., & Mesulam, M. M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1006 · Cited by 139 · cited 1×
“and also by inputs from higher-level structures that are involved in goal-directed contro”
Imaging neurodegeneration in Parkinson's disease
Pavese, N., & Brooks, D. J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.003 · Cited by 130 · cited 1×
“A model of basal ganglia dysfunction When the classic motor features of Parkinson's disease appear, dopaminergic neurons in ventrolateral substantia nigra and their terminals in the caudolateral sensorimotor putamen are differentially susceptible to degeneratio”
Changing views of basal ganglia circuits and circuit disorders
DeLong, M., & Wichmann, T. (2010) · Clinical EEG and Neuroscience · doi:10.1177/155005941004100204 · Cited by 128
The intrinsic and extrinsic aspects of freezing of gait
Hallett, M. (2008) · Movement Disorders · doi:10.1002/mds.21836 · Cited by 126 · cited 1×
“5 ), then these patients would have to perform most, if not all, aspects of tasks — from the mundane to the complex — in a volitional and goal-directed manne”
Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
Pedersen, K. F., Alves, G. W., Aarsland, D., & Larsen, J. P. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.170043 · Cited by 121 · cited 1×
“It is, however, important to recognize that with increasing and progressive involvement of more medial sectors of the basal ganglia some of the motivational and cognitive symptoms of abulia — in particular, apathy — also become evident in Parkinson's diseas”
The clinical spectrum of freezing of gait in Parkinson's disease
Okuma, Y., & Yanagisawa, N. (2008) · Movement Disorders · doi:10.1002/mds.21934 · Cited by 119 · cited 1×
“Indeed, these patients require a conscious decision to start walking and they stop abruptly if they are distracted by a different external stimulus, a new idea or another behaviour (for example, talking”
Effective connectivity of neural networks in automatic movements in Parkinson's disease
Wu, T., Chan, P., & Hallett, M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.051 · Cited by 118
Habitual versus goal-directed action control in Parkinson disease
de Wit, S., Barker, R. A., Dickinson, A. D., & Cools, R. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21514 · Cited by 116 · cited 1×
“The importance of formal testing is also highlighted by a recent report that habit formation in an instrumental conflict task was preserved in patients with Parkinson's diseas”
Paradoxes of functional neurosurgery: Clues from basal ganglia recordings
Brown, P., & Eusébio, A. (2007) · Movement Disorders · doi:10.1002/mds.21796 · Cited by 113 · cited 1×
“The apparent impunity with which the basal ganglia can be lesioned to treat movement disorders without catastrophic effects on behaviour is a well recognized parado”
Obeso, J. A., Jahanshahi, M., Álvarez, L., Macıás, R., Pedroso, I., Wilkinson, L., Pavon, N., Day, B. L., Pinto, S., Rodríguez‐Oroz, M., et al. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.030 · Cited by 109 · cited 1×
“Initial studies that were limited to a few patients are encouraging in that lesions of basal ganglia output systems in patients with Parkinson's disease improved basic motor features, whereas new learning and complex motor performance remained impaire”
Scholz, V. H., Flaherty, A. W., Kraft, E., Keltner, J. R., Kwong, K. K., Chen, Y. I., Rosen, B. R., & Jenkins, B. G. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02749-9 · Cited by 100
Evidence for Segregated and Integrative Connectivity Patterns in the Human Basal Ganglia
Draganski, B., Kherif, F., Klöppel, S., Cook, P. A., Alexander, D. C., Parker, G. J. M., Deichmann, R., Ashburner, J., & Frackowiak, R. S. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1486-08.2008 · Cited by 100
Monkey globus pallidus external segment neurons projecting to the neostriatum
Kita, H., Tokuno, H., & Nambu, A. (1999) · Neuroreport · doi:10.1097/00001756-199905140-00014 · Cited by 94
Evidence for a distinct nigropallidal dopaminergic projection in the squirrel monkey
Smith, Y., Lavoie, B. A., Dumas, J., & Parent, A. (1989) · Brain Research · doi:10.1016/0006-8993(89)91205-5 · Cited by 83 · cited 1×
“There is also a sparser dopaminergic innervation of both the globus pallidu”
Lanciego, J. L., Gonzalo, N., Castle, M., Sanchez‐Escobar, C., Aymerich, M. S., & Obeso, J. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03244.x · Cited by 83
Bevan, M. D., Bolam, J. P., & Crossman, A. R. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00275.x · Cited by 82 · cited 1×
“Here, reduced STN activity and corresponding reductions in basal ganglia inhibitory output would facilitate involuntary movement”
Coizet, V., Graham, J. H., Moss, J., Bolam, J. P., Savasta, M., McHaffie, J. G., Redgrave, P., & Overton, P. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0247-09.2009 · Cited by 80
Erro, E., Lanciego, J. L., & Giménez‐Amaya, J. M. (1999) · Experimental Brain Research · doi:10.1007/s002210050786 · Cited by 78
Rivlin‐Etzion, M., Marmor, O., Saban, G., Rosin, B., Haber, S. N., Vaadia, E., Prut, Y., & Bergman, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3388-07.2008 · Cited by 78 · cited 1×
“This would be consistent with the observation that an attempt to mimic parkinsonian tremor by stimulating GPi in monkeys did not change motor cortex excitability or induce tremor, suggesting that parkinsonian tremor may develop in downstream motor circuit”
HEMICHOREA ASSOCIATED WITH A LESION OF THE CORPUS LUYSII
MARTIN, J. P., & Alcock, N. S. (1934) · Brain · doi:10.1093/brain/57.4.504 · Cited by 78
Athymhormia and Disorders of Motivation in Basal Ganglia Disease
Habib, M. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.4.509 · Cited by 77 · cited 1×
“A similar double dissociation seems to emerge from comparing patients with Parkinson's disease with those suffering from cognitive abulia”
Serum Renin Levels and Postnephrectomy Blood Pressure
Cotzias, G. C., Papavasiliou, P. S., & Gellene, R. (1969) · New England Journal of Medicine · doi:10.1056/nejm196907312810518 · Cited by 77
Darvas, M., & Palmiter, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907299106 · Cited by 75 · cited 1×
“On the one hand, dopamine replacement therapies might be expected to reinstate some degree of habitual sensorimotor contro”
The Basal Ganglia Iv: New Ideas And Data On Structure And Function
Percheron, G., McKenzie, J. S., & Férger, J. (2011) · Medical Entomology and Zoology · Cited by 73
Berretta, S., Munno, D. W., & Benes, F. M. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010305)431:2 · Cited by 68
Doubell, T. P., Skaliora, I., Baron, J., & King, A. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06596.2003 · Cited by 64 · cited 1×
“These motor neurons may be driven by direct sensory inputs (for stimulus–response habitual responding”
Stimulus-response and response-outcome learning mechanisms in the striatum
Horvitz, J. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.014 · Cited by 58
Jubault, T., Monetta, L., Strafella, A. P., Lafontaine, A., & Monchi, O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006154 · Cited by 52 · cited 1×
“On the one hand, dopamine replacement therapies might be expected to reinstate some degree of habitual sensorimotor contro”
Topography of cortico‐striatal connections in man: anatomical evidence for parallel organization
Wiesendanger, E., Clarke, S., Kraftsik, R., & Tardif, É. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03640.x · Cited by 50 · cited 1×
“A widely recognized feature of connections between the intrinsic nuclei of the basal ganglia is their high degree of spatial topograph”
Models of the subthalamic nucleus: The importance of intranuclear connectivity
Gillies, A., & Willshaw, D. J. (2004) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2004.06.003 · Cited by 47
Abulia: A Delphi survey of British neurologists and psychiatrists
Vijayaraghavan, L., Krishnamoorthy, E. S., Brown, R. G., & Trimble, M. (2002) · Movement Disorders · doi:10.1002/mds.10194 · Cited by 41 · cited 1×
“A similar double dissociation seems to emerge from comparing patients with Parkinson's disease with those suffering from cognitive abulia”
Heuer, H., Spijkers, W. A. C., Kiesswetter, E., & Schmidtke, V. (1998) · Journal of Experimental Psychology Applied · doi:10.1037//1076-898x.4.2.139 · Cited by 40 · cited 1×
“Chronic stress also favours stimulus–response, habitual contro”
ACUTE HEMIBALLISMUS TREATED BY VENTROLATERAL THALAMOLYSIS
Martin, J. P., & McCaul, I. R. (1959) · Brain · doi:10.1093/brain/82.1.104 · Cited by 39
Provision of External Cues and Movement Sequencing in Parkinson's Disease
Rogers, M. A., Phillips, J. G., Bradshaw, J. L., lansek, R., & Jones, D. L. (1998) · Motor Control · doi:10.1123/mcj.2.2.125 · Cited by 34
Neurobiological Basis of Controlling Posture and Locomotion
Takakusaki, K., & Okumura, T. (2008) · Advanced Robotics · doi:10.1163/156855308x368958 · Cited by 31 · cited 1×
“The last place where the proposed convergence could take place is through multisynaptic relays terminating on common motor neurons in the brainstem and spinal cor”
The microcircuitry of primate subthalamic nucleus
Parent, M., & Parent, A. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70018-x · Cited by 30
Redgrave, P. (2007) · Scholarpedia · doi:10.4249/scholarpedia.1825 · Cited by 29
Heuer, H., Spijkers, W. A. C., Kiesswetter, E., et al. (1998) · Journal of Experimental Psychology Applied · doi:10.1037/1076-898x.4.2.139 · Cited by 29
Gaba and the Basal Ganglia - From Molecules to Systems
(2007) · Progress in brain research · doi:10.1016/s0079-6123(06)x6000-4 · Cited by 25
Hypokinesia of associated movement in Parkinson's disease: A symptom in early stages of the disease
Hoshiyama, M., Kaneoke, Y., Koike, Y., Takahashi, A., & Watanabe, S. (1994) · Journal of Neurology · doi:10.1007/bf00873512 · Cited by 25 · cited 1×
“Indeed, it has long been known that patients with Parkinson's disease have difficulties expressing automatic components of behaviou”
Parallel explicit and implicit control of reaching
Mazzoni, P., & Wexler, N. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007557 · Cited by 24 · cited 1×
“This suggests that many skills can be deconstructed into sequenced combinations of both goal-directed and habitual control working in concer”
Brain structure in movement disorders: a neuroimaging perspective
Draganski, B., & Bhatia, K. P. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833bc59c · Cited by 23 · cited 1×
“The same would be true for other conditions in which differential impairment across the functional subregions of the striatum may have taken place — for example, in patients with different phenotypes of Huntington's disease and in patients with Tourette's syndrome with or without obsessive–compulsive disorde”
Lozza, A., Pepin, J. L., Rapisarda, G., Moglia, A., & Delwaide, P. J. (1997) · Journal of Neural Transmission · doi:10.1007/bf01291885 · Cited by 21 · cited 1×
“Third, it is also noted that some automatic movements (for example, conditioning of the blink reflex) are preserved in patients with Parkinson's diseas”
McHaffie, C. M. T. J. G. (2001) · Somatosensory & Motor Research · doi:10.1080/135578501012006200 · Cited by 19
Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. R. (1994) · Advances in behavioral biology · doi:10.1007/978-1-4613-0485-2_33 · Cited by 16
Concurrent discrimination learning in Parkinson’s disease.
Moody, T. D., Chang, G. Y., Vanek, Z. F., & Knowlton, B. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018414 · Cited by 15 · cited 1×
“Consequently, patients with Parkinson's disease would be expected to have great difficulty developing habitual responding despite repeated practic”
Doron, O., & Goelman, G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.032 · Cited by 12
Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia
Miwa, H., Fuwa, T., Nishi, K., & Kondo, T. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00039 · Cited by 8
Research works printed but not linked: 4
- Bolam, J. P. & Bennett, B. D. in Molecular and Cellular Mechanims of Neostriatal Function (eds Ariano, M. A. & Surmeier, D. J.) 1–19 (R. G. Landes Co., Texas, 1995).
- Thorndike, E. L. Animal Intelligence. (Macmillan, New York, 1911).
- Wilson, S. A. K. Disorders of motility and tone. Lancet Neurol. 1, 1–103 (1925).
- Cotzias, G. C., Papavasiliou, P. S. & Gellene, R. L-dopa in Parkinson's syndrome. N. Engl. J. Med. 281, 272 (1969).
Cited by
Sorted by citations
Direct and indirect pathways of basal ganglia: a critical reappraisal
Calabresi, P., Picconi, B., Tozzi, A., Ghiglieri, V., & Filippo, M. D. (2014) · Nature Neuroscience · doi:10.1038/nn.3743 · Cited by 820
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
Nociception, pain, negative moods, and behavior selection
Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731
Current principles of motor control, with special reference to vertebrate locomotion
Grillner, S., & El Manira, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00015.2019 · Cited by 560
A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4038 · Cited by 521
Metadata
- Authors
- Redgrave, P., Rodriguez, M., Smith, Y., Rodriguez-Oroz, M. C., Lehericy, S., Bergman, H., Agid, Y., DeLong, M. R., & Obeso, J. A.
- Affiliations
- University of Sheffield (GB)
- Emory University (US)
- Hebrew University of Jerusalem (IL)
- Institut du Cerveau (FR)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Corresponding author
- Redgrave, Peter
- Obeso, Jose A.
- Venue
- Nature reviews. Neuroscience
- Published
- 2010-10-14
- Volume
- 11
- Issue
- 11
- Pages
- 760-772
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3124757
- OpenAlex
- W2056061278
- Cited by
- 1,134
- References
- 178
- Citations by year
- 2026: 59 · 2025: 78 · 2024: 74 · 2023: 70 · 2022: 90 · 2021: 78 · 2020: 75 · 2019: 122 · 2018: 64 · 2017: 62 · 2016: 73 · 2015: 65 · 2014: 72 · 2013: 68 · 2012: 47
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (091409)
- Universidad de Navarra
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- basal ganglia, Parkinson's disease, goal-directed behavior, habitual behavior, dopamine depletion, posterior putamen, action control
- MeSH terms
- Animals, Basal Ganglia, Goals, Habituation, Psychophysiologic, Humans, Models, Neurological, Nerve Net, Neural Pathways, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
