The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
The circadian clock and pathology of the ageing brain
Open accessAbstract
Ageing leads to a functional deterioration of many brain systems, including the circadian clock--an internal time-keeping system that generates ∼24-hour rhythms in physiology and behaviour. Numerous clinical studies have established a direct correlation between abnormal circadian clock functions and the severity of neurodegenerative and sleep disorders. Latest data from experiments in model organisms, gene expression studies and clinical trials imply that dysfunctions of the circadian clock contribute to ageing and age-associated pathologies, thereby suggesting a functional link between the circadian clock and age-associated decline of brain functions. Potential molecular mechanisms underlying this link include the circadian control of physiological processes such as brain metabolism, reactive oxygen species homeostasis, hormone secretion, autophagy and stem cell proliferation.
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“Normalization of the dysregulated circadian clock may decelerate brain ageing.488”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [488]
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Metadata
- Authors
- Kondratova, A. A., & Kondratov, R. V.
- Affiliations
- Cleveland Clinic (US)
- Cleveland State University (US)
- Corresponding author
- Kondratov, Roman V.
- Venue
- Nature Reviews Neuroscience
- Published
- 2012-03-07
- Volume
- 13
- Issue
- 5
- Pages
- 325-335
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3718301
- OpenAlex
- W2077676121
- Cited by
- 482
- References
- 143
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 28 · 2023: 24 · 2022: 49 · 2021: 44 · 2020: 41 · 2019: 24 · 2018: 30 · 2017: 48 · 2016: 36 · 2015: 40 · 2014: 26 · 2013: 32 · 2012: 8
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R03AG033881, R01AG039547)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, brain aging, neurodegeneration, sleep disorders, brain metabolism, reactive oxygen species, hormone secretion, autophagy, stem cell proliferation, circadian rhythm
- MeSH terms
- Aging, Animals, Brain, Circadian Rhythm, Cognition Disorders, Humans, Circadian Clocks
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