Cited by 482Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsSleep and Wakefulness Research

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The circadian clock and pathology of the ageing brain

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Kondratova, Anna A., Kondratov, Roman V.·2012·Nature Reviews Neuroscience

DOI 10.1038/nrn3208PMC PMC3718301

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Abstract

Ageing leads to a functional deterioration of many brain systems, including the circadian clock--an internal time-keeping system that generates ∼24-hour rhythms in physiology and behaviour. Numerous clinical studies have established a direct correlation between abnormal circadian clock functions and the severity of neurodegenerative and sleep disorders. Latest data from experiments in model organisms, gene expression studies and clinical trials imply that dysfunctions of the circadian clock contribute to ageing and age-associated pathologies, thereby suggesting a functional link between the circadian clock and age-associated decline of brain functions. Potential molecular mechanisms underlying this link include the circadian control of physiological processes such as brain metabolism, reactive oxygen species homeostasis, hormone secretion, autophagy and stem cell proliferation.

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Authors: Kondratova, A. A., & Kondratov, R. V.
Affiliations: Cleveland Clinic (US)
Cleveland State University (US)
Corresponding author: Kondratov, Roman V.
ORCID: Kondratova, Anna A.
Kondratov, Roman V.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2012-03-07
Volume: 13
Issue: 5
Pages: 325-335
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3208
PMC: PMC3718301
OpenAlex: W2077676121
Cited by: 482
References: 143
Citations by year: 2026: 23 · 2025: 29 · 2024: 28 · 2023: 24 · 2022: 49 · 2021: 44 · 2020: 41 · 2019: 24 · 2018: 30 · 2017: 48 · 2016: 36 · 2015: 40 · 2014: 26 · 2013: 32 · 2012: 8
FWCI: 3.83
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R03AG033881, R01AG039547)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: circadian clock, brain aging, neurodegeneration, sleep disorders, brain metabolism, reactive oxygen species, hormone secretion, autophagy, stem cell proliferation, circadian rhythm
MeSH terms: Aging, Animals, Brain, Circadian Rhythm, Cognition Disorders, Humans, Circadian Clocks

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The circadian clock and pathology of the ageing brain

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