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DSM-5 and RDoC: progress in psychiatry research?
Open accessAbstract
Neuroscience studies into psychiatric disorders generally rely on disease definitions that are based on the influential Diagnostic and Statistical Manual of Mental Disorders (DSM), the fifth edition of which (DSM-5) was released earlier this year. Designed as a purely diagnostic tool, the DSM considers different disorders as distinct entities. However, boundaries between disorders are often not as strict as the DSM suggests. To provide an alternative framework for research into psychiatric disorders, the US National Institute of Mental Health (NIMH) has recently introduced its Research Domain Criteria (RDoC) project. In the RDoC, five 'domains' each reflect a brain system in which functioning is impaired, to different degrees, in different psychiatric conditions. Nature Reviews Neuroscience asked six leading investigators for their thoughts on how DSM-5 and the RDoC will influence neuroscience research into psychiatric disorders.
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“most phenotypes are based on clinical and behavioural symptomatology rather than on biological mechanism or aetiology22–24.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [22]
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Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
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Self-citationNeuroscience, Clinical Evidence, and the Future of Psychiatric Classification in DSM-5
Kupfer, D. J., & Regier, D. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020219 · Cited by 245
Felmingham, K. L., Dobson‐Stone, C., Schofield, P. R., Quirk, G. J., & Bryant, R. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.033 · Cited by 167
Kupfer, D. J., Kuhl, E. A., & Regier, D. A. (2013) · JAMA · doi:10.1001/jama.2013.2298 · Cited by 82
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Acosta, J. N., Falcone, G. J., Rajpurkar, P., & Topol, E. J. (2022) · Nature Medicine · doi:10.1038/s41591-022-01981-2 · Cited by 1,365
“Similarly, the Diagnostic and Statistical Manual of Mental Disorders categorizes diagnoses based on clinical manifestations, which might not fully represent underlying pathophysiological processes 143 .”
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“…trend in psychological science consisting of delineating biological processes underlying psychological phenomena (e.g., Blair & Diamond, 2008; Casey et al., 2013; Insel et al., 2010; Sanislow et al., 2010), the study of emotion regulation has been placing great emphasis on identifying…”
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Metadata
- Authors
- Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S., & Ressler, K. J.
- Affiliations
- Cornell University (US)
- Cardiff University (GB)
- National Institutes of Health (US)
- Broad Institute (US)
- Weill Cornell Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Casey, B. J.
- Craddock, Nick
- Cuthbert, Bruce N.
- Hyman, Steven E.
- Lee, Francis S.
- Ressler, Kerry J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-10-18
- Volume
- 14
- Issue
- 11
- Pages
- 810-814
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4372467
- OpenAlex
- W1997159235
- Cited by
- 434
- References
- 5
- Citations by year
- 2026: 5 · 2025: 32 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 31 · 2020: 75 · 2019: 47 · 2018: 39 · 2017: 38 · 2016: 32 · 2015: 41 · 2014: 23 · 2013: 1
- FWCI
- 236.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute of Mental Health (P50MH079513)
- National Institute of Neurological Disorders and Stroke (R01NS052819)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- DSM-5, Research Domain Criteria, psychiatric classification, dimensional psychiatry, diagnostic criteria, psychiatric neuroscience, mental illness, National Institute of Mental Health
- MeSH terms
- Mental Disorders, Brain, Humans, National Institute of Mental Health (U.S.), Neuropsychological Tests, Psychiatry, United States, Biomedical Research, Diagnostic and Statistical Manual of Mental Disorders
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