Neurobiology of rodent self-grooming and its value for translational neuroscience
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Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.
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Grooming in WT mice is highly sensitive to experimental conditions including stressful situations such as a novel environment or exposure to bright light.
“Grooming in WT mice is highly sensitive to experimental conditions including stressful situations such as a novel environment or exposure to bright light [32].”
From Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice (2020) · cites this paper as [32]
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- Authors
- Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C.
- Affiliations
- Ural Federal University (RU)
- Dalhousie University (CA)
- University of Michigan (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Kalueff, Allan V.
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-12-17
- Volume
- 17
- Issue
- 1
- Pages
- 45-59
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4840777
- OpenAlex
- W2205794177
- Cited by
- 852
- References
- 204
- Citations by year
- 2026: 79 · 2025: 101 · 2024: 95 · 2023: 87 · 2022: 95 · 2021: 98 · 2020: 78 · 2019: 91 · 2018: 54 · 2017: 51 · 2016: 22
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-01-25)
- Open access
- bronze
- doi.org
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Electronic Archive of Ural Federal University (ELAR UrFU) (submittedVersion)
- Electronic scientific archive of UrFU (Ural Federal University) (submittedVersion)
- Funders
- California Institute of Technology
- Saint Petersburg State University (1.38.201.2014)
- Ural Federal University (02-A03.21.0006)
- Guangdong Ocean University
- National Institutes of Health (DA015188)
- National Institute of Mental Health (MH060379, MH-63649, R01MH063649, R01MH060379)
- National Institute on Drug Abuse (DA015188, R01DA015188)
- National Institute of Neurological Disorders and Stroke (NS-025529, R01NS025529, R56NS025529)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD028341, R37HD028341, HD028341)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- self-grooming, rodent behavior, repetitive behavior, neural circuits, autism spectrum disorder, obsessive-compulsive disorder, translational psychiatry, innate behavior, behavioral phenotyping
- MeSH terms
- Autism Spectrum Disorder, Animals, Behavior, Animal, Disease Models, Animal, Grooming, Humans, Neurobiology, Obsessive-Compulsive Disorder
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