Cited by 852Obsessive-Compulsive Spectrum DisordersGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Neurobiology of rodent self-grooming and its value for translational neuroscience

Open access
Kalueff, Allan V., Stewart, Adam Michael, Song, Cai, Berridge, Kent C., Graybiel, Ann M., Fentress, John C.·2016·Nature Reviews Neuroscience

Abstract

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrn.2015.8

Cites

204 of 204 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Grooming in WT mice is highly sensitive to experimental conditions including stressful situations such as a novel environment or exposure to bright light.

    “Grooming in WT mice is highly sensitive to experimental conditions including stressful situations such as a novel environment or exposure to bright light [32].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [63]Berridge KC Aldridge JW Super-stereotypy I: enhancement of a complex movement sequence by systemic dopamine D1 agonists Synapse 2000 37 194 204 10881041
  2. [177]Pigott TA L’Heureux F Dubbert B Bernstein S Murphy DL Obsessive compulsive disorder: comorbid conditions J. Clin. Psychiatry 1994 55 Suppl 15 27 7961529

Cited by

Sorted by citations

Authors
Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C.
Affiliations
  • Ural Federal University (RU)
  • Dalhousie University (CA)
  • University of Michigan (US)
  • McGovern Institute for Brain Research (US)
Corresponding author
Kalueff, Allan V.
Venue
Nature Reviews Neuroscience
Published
2015-12-17
Volume
17
Issue
1
Pages
45-59
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2205794177
Cited by
852
References
204
Citations by year
2026: 79 · 2025: 101 · 2024: 95 · 2023: 87 · 2022: 95 · 2021: 98 · 2020: 78 · 2019: 91 · 2018: 54 · 2017: 51 · 2016: 22
FWCI
6.13
Type
journal article
Language
en
Update notices
erratum (2016-01-25)
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Electronic Archive of Ural Federal University (ELAR UrFU) (submittedVersion)
  • Electronic scientific archive of UrFU (Ural Federal University) (submittedVersion)
Funders
  • California Institute of Technology
  • Saint Petersburg State University (1.38.201.2014)
  • Ural Federal University (02-A03.21.0006)
  • Guangdong Ocean University
  • National Institutes of Health (DA015188)
  • National Institute of Mental Health (MH060379, MH-63649, R01MH063649, R01MH060379)
  • National Institute on Drug Abuse (DA015188, R01DA015188)
  • National Institute of Neurological Disorders and Stroke (NS-025529, R01NS025529, R56NS025529)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD028341, R37HD028341, HD028341)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
self-grooming, rodent behavior, repetitive behavior, neural circuits, autism spectrum disorder, obsessive-compulsive disorder, translational psychiatry, innate behavior, behavioral phenotyping
MeSH terms
Autism Spectrum Disorder, Animals, Behavior, Animal, Disease Models, Animal, Grooming, Humans, Neurobiology, Obsessive-Compulsive Disorder

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review