Advances in understanding and treatment of Tourette syndrome

McNaught, Kevin St. P.; Mink, Jonathan W.

doi:10.1038/nrneurol.2011.167

Cited by 196Obsessive-Compulsive Spectrum DisordersNeurological disorders and treatmentsStuttering Research and Treatment

Advances in understanding and treatment of Tourette syndrome

McNaught, Kevin St. P., Mink, Jonathan W.·2011·Nature Reviews Neurology

DOI 10.1038/nrneurol.2011.167

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Abstract

Tourette syndrome is a hereditary, childhood-onset neurodevelopmental disorder that was first clearly described in France in 1885. This disorder is characterized by sudden, rapid, recurrent, nonrhythmic movements (motor tics) or sounds (vocal or phonic tics), often preceded by premonitory sensations or urges. Some individuals also have psychiatric comorbidities, notably attention-deficit hyperactivity disorder or obsessive-compulsive disorder. Tourette syndrome occurs worldwide, in all races and ethnicities, in both sexes and in children as well as in adults. Estimates of its prevalence in children vary, with rates of up to 1% being reported, but rates of 0.3-0.8% are thought to accurately reflect the occurrence of the disorder. Research has led to progress in many aspects of Tourette syndrome, although many questions and unmet needs remain. For example, except for rare cases, the genetic basis remains elusive. The anatomical and neuronal changes in the brain that underlie Tourette syndrome are also unclear, although the evidence increasingly implicates alterations in basal ganglia function. Treatment is often unnecessary for individuals with mild tics, but for those with moderate to severe forms of the syndrome, some drugs are available, albeit frequently ineffective. Behavioral and surgical therapies, in particular deep brain stimulation, are currently undergoing development and show promising results. This Review examines the history of Tourette syndrome and describes its clinical presentation. The article also provides an overview of the epidemiology and pathophysiology of this disorder. Current treatment strategies and potential future therapies are also discussed.

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TS affects 0.3 to 0.8% of the population.
“TS affects 0.3 to 0.8% of the population [612]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [612]

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Stereotactic Surgery for Treating Intractable Tourette Syndrome: A Single-Center Pilot Study
Wang, X., Qu, L., Ge, S., Li, N., Wang, J., Qiu, C., Kou, H., Li, J., Jing, J., Su, M., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12070838 · Cited by 6 · see citing works
Insights for treatment in Tourette syndrome from fMRI
Greene, D. J., & Schlaggar, B. L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.006 · Cited by 6 · see citing works

Authors: McNaught, K. S. P., & Mink, J. W.
Affiliations: Tourette Association of America (US)
University of Rochester Medicine (US)
Corresponding author: McNaught, Kevin St. P.
ORCID: Mink, Jonathan W.
Venue: Nature Reviews Neurology
Publisher: Springer Science and Business Media LLC
Published: 2011-11-08
Volume: 7
Issue: 12
Pages: 667-676
ISSN: 1759-4758 (ISSN-L)
1759-4766
DOI: 10.1038/nrneurol.2011.167
OpenAlex: W2027004239
Cited by: 196
References: 79
Citations by year: 2026: 3 · 2025: 31 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 20 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 15 · 2015: 14 · 2014: 18 · 2013: 17 · 2012: 16
FWCI: 2.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Social Sciences › Psychology › Clinical Psychology › Stuttering Research and Treatment
Keywords: Tourette syndrome, motor tics, vocal tics, premonitory urges, neurodevelopmental disorders, pathophysiology, basal ganglia, genetic basis, psychiatric comorbidity, attention deficit hyperactivity disorder, obsessive-compulsive disorder, deep brain stimulation, behavior therapy, surgical treatment, future therapies
MeSH terms: Animals, Behavior Therapy, Tourette Syndrome, Humans, Treatment Outcome, Dopamine Antagonists, Comprehension, Deep Brain Stimulation

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