The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
T cells as therapeutic targets in SLE
Open accessAbstract
T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus erythematosus (SLE), and seem to be directly involved in the development of related organ pathology. Defects associated with CD8+ and T-regulatory (TREG) cell function manifest in parallel with the expanded CD3+CD4−CD8− T cell lineage. The cytokine expression pattern is uniquely characterized by decreased expression of interleukin (IL)-2 and increased production of IL-17 and related cytokines. Therapeutic approaches that limit the cognate interaction between T cells and B cells, prevent inappropriate tissue homing and restore TREG cell function and the normal cytokine milieu have been entertained. Biochemical characterization of SLE T cells has revealed distinct early and late signaling aberrations, and has enabled the identification of novel molecular targets that can be corrected with small molecules, and biomarkers that may foretell disease activity and predict organ damage.
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1 retracted
Doreau, A., Belot, A., Bastid, J., Riche, B., Trescol-Biemont, M.-C., Ranchin, B., Fabien, N., Cochat, P., Pouteil-Noble, C., Trolliet, P., et al. (2009) · Nature Immunology · doi:10.1038/ni.1741 · Cited by 452
RetractedKorn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309 · cited 1×
“Altered gene transcription A number of large-scale genome-wide association studies have identified several genetic loci that harbor genes assumed to be associated with the development of SLE”
BackgroundAssociation of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX
Hom, G., Graham, R. R., Modrek, B., Taylor, K. E., Ortmann, W., Garnier, S., Lee, A. T., Chung, S. A., Ferreira, R. C., Pant, P. V. K., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707865 · Cited by 914
Crispín, J. C., Oukka, M., Bayliss, G., Cohen, R. A., Van Beek, C. A., Stillman, I. E., Kyttaris, V. C., Juang, Y.-T., & Tsokos, G. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8761 · Cited by 789
Self-citationHsu, H.-C., Yang, P., Wang, J., Wu, Q., Myers, R., Chen, J., Yi, J., Guentert, T., Tousson, A., Stanus, A. L., et al. (2008) · Nature Immunology · doi:10.1038/ni1552 · Cited by 716
Simpson, N., Gatenby, P. A., Wilson, A., Malik, S., Fulcher, D. A., Tangye, S. G., Manku, H., Vyse, T. J., Roncador, G., Huttley, G. A., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.25032 · Cited by 684
Treatment of Murine Lupus with CTLA4Ig
Finck, B. K., Linsley, P. S., & Wofsy, D. (1994) · Science · doi:10.1126/science.7520604 · Cited by 668
Boumpas, D. T., Furie, R., Manzi, S., Illei, G. G., Wallace, D. J., Balow, J. E., Vaishnaw, A., & on behalf of the BG9588 Lupus Nephritis Trial Group (2003) · Arthritis & Rheumatism · doi:10.1002/art.10856 · Cited by 618
Valencia, X., Yarboro, C., Illei, G., & Lipsky, P. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2579 · Cited by 594
Cited by
Taming lupus-a new understanding of pathogenesis is leading to clinical advances
Liu, Z., & Davidson, A. (2012) · Nature Medicine · doi:10.1038/nm.2752 · Cited by 433
Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity
Carmona-Rivera, C., & Kaplan, M. J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0375-7 · Cited by 342
Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
Apostolidis, S. A., Rauen, T., Hedrich, C. M., Tsokos, G. C., & Crispín, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483743 · Cited by 91
Self-citationOrtmann, W., & Kolaczkowska, E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2751-4 · Cited by 80
Tang, Y., Wang, L., Zhu, M., Yang, M., Zhong, K., Du, Q., Zhang, H., & Gui, M. (2015) · Scientific Reports · doi:10.1038/srep10817 · Cited by 14
Metadata
- Authors
- Crispín, J. C., Kyttaris, V. C., Terhorst, C., & Tsokos, G. C.
- Venue
- Nature Reviews Rheumatology
- Published
- 2010-05-11
- Volume
- 6
- Issue
- 6
- Pages
- 317-325
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W1985613212
- Cited by
- 271
- References
- 96
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Crispín, J. C., Kyttaris, V. C., Terhorst, C., & Tsokos, G. C. (2010). T cells as therapeutic targets in SLE. Nature Reviews Rheumatology. https://doi.org/10.1038/nrrheum.2010.60
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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