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Cited by 1,190

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Viral membrane fusion

Open access
Harrison, Stephen C·2008·Nature Structural & Molecular Biology

Abstract

Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral 'fusion proteins' facilitate this process. They vary greatly in structure, but all seem to have a common mechanism of action, in which a ligand-triggered, large-scale conformational change in the fusion protein is coupled to apposition and merger of the two bilayers. We describe three examples—the influenza virus hemagglutinin, the flavivirus E protein and the vesicular stomatitis virus G protein—in some detail, to illustrate the ways in which different structures have evolved to implement this common mechanism. Fusion inhibitors can be effective antiviral agents.

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Metadata

Authors
Harrison, S. C.
Venue
Nature Structural & Molecular Biology
Published
2008-07
Volume
15
Issue
7
Pages
690-698
ISSN
  • 1545-9985 (ISSN-L)
  • 1545-9993
OpenAlex
W2096025413
Cited by
1,190
References
5
FWCI
49.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Viral membrane fusion. https://app.cochat.ai/papers/10.1038/nsmb.1456
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Harrison, S. C. (2008). Viral membrane fusion. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1456

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.