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Regulation of nucleosome dynamics by histone modifications
Abstract
Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.
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“histones enter in nucleosome formation and proper DNA wrapping after the S phase of cell cycle [65]”
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Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling
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The Histone Modifications Governing TFF1 Transcription Mediated by Estrogen Receptor
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Flagged first, then by citations
1 of the 111 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Lämke, J., & Bäurle, I. (2017) · Genome biology · doi:10.1186/s13059-017-1263-6 · Cited by 954
“org/publicdomain/ze The structure of chromatin regulates the accessibility of genes for the transcriptional machinery, and is thus an integral part of regulated gene expression in stress responses and development [8, 9].”
BackgroundGetting up to speed with transcription elongation by RNA polymerase II
Jonkers, I., & Lis, J. T. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3953 · Cited by 876
Understanding nucleosome dynamics and their links to gene expression and DNA replication
Lai, W. K. M., & Pugh, B. F. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.47 · Cited by 495
Lämke, J., Brzezinka, K., Altmann, S., & Bäurle, I. (2015) · The EMBO Journal · doi:10.15252/embj.201592593 · Cited by 452
“For example, histone acetylation is associated with active transcription and correlates closely with the rate of transcription (Zentner & Henikoff, 2013).”
Metadata
- Authors
- Zentner, G. E., & Henikoff, S.
- Affiliations
- Fred Hutch Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Henikoff, Steven
- Venue
- Nature Structural & Molecular Biology
- Published
- 2013-03
- Volume
- 20
- Issue
- 3
- Pages
- 259-266
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2034340491
- Cited by
- 923
- References
- 111
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 57 · 2023: 39 · 2022: 45 · 2021: 60 · 2020: 63 · 2019: 82 · 2018: 75 · 2017: 84 · 2016: 76 · 2015: 106 · 2014: 125 · 2013: 52
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5u01hg004274-04)
- National Human Genome Research Institute (5U01 HG004274)
- National Cancer Institute (T32CA009657, U54CA143862)
- National Institute of Environmental Health Sciences (R01ES020116)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- nucleosome dynamics, histone modifications, chromatin, nucleosome mobility, nucleosome turnover, transcription, DNA replication, DNA repair
- MeSH terms
- Acetylation, Acylation, Adenosine Diphosphate, Chromatin, DNA, DNA Replication, Gene Expression Regulation, Glycosylation, Histones, Lysine, Methylation, Nucleosomes
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