The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
Open accessAbstract
Long noncoding RNAs (lncRNAs) play critical roles during tumorigenesis by functioning as scaffolds that regulate protein-protein, protein-DNA or protein-RNA interactions. Using a clinically guided genetic screening approach, we identified lncRNA in nonhomologous end joining (NHEJ) pathway 1 (LINP1), which is overexpressed in human triple-negative breast cancer. We found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway. Importantly, blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer.
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Cited by
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
Stinson, B. M., & Loparo, J. J. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080320-110356 · Cited by 223
Unfried, J. P., Marín-Baquero, M., Rivera-Calzada, Á., Razquin, N., Martín-Cuevas, E. M., de Bragança, S., Aicart-Ramos, C., McCoy, C., Prats-Mari, L., Arribas-Bosacoma, R., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0463 · Cited by 48
Amirnorouzi, M., Karimi, A., Daryani, N. E., Rajaei, A., Hashemi, M., & Alebouyeh, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-74138-5 · Cited by 4
Metadata
- Authors
- Zhang, Y., He, Q., Hu, Z., Feng, Y., Fan, L., Tang, Z., Yuan, J., Shan, W., Li, C., Hu, X., Tanyi, J. L., Fan, Y., Huang, Q., Montone, K., Dang, C. V., & Zhang, L.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2016-04-25
- Volume
- 23
- Issue
- 6
- Pages
- 522-530
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2343471288
- Cited by
- 331
- References
- 40
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, Y., He, Q., Hu, Z., Feng, Y., Fan, L., Tang, Z., Yuan, J., Shan, W., Li, C., Hu, X., Tanyi, J. L., Fan, Y., Huang, Q., Montone, K., Dang, C. V., & Zhang, L. (2016). Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.3211
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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