A new nuclease member of the FAN club
Open accessAbstract
To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.
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Because monoubiquitination events are independent of BRCA1, BRCA2/FANCD1, PALB2/FANCN, BACH1/FANCJ/BRIP1, and RAD51C, these proteins act downstream in the BRCA-FA pathway.
“Because these monoubiquitination events are independent of BRCA1, BRCA2/FANCD1, PALB2/FANCN, BACH1/FANCJ/BRIP1 or RAD51C, these proteins are considered to function downstream in the BRCA-FA pathway.”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [32]
Activation of the BRCA-FA pathway is typically measured by DNA damage-induced monoubiquitination of FANCD2 and FANCI.
“Activation of the BRCA-FA pathway is typically measured by the DNA damage-induced monoubiquitination of FANCD2 and, more recently, FANCI [32].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [32]
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- [13]Liu T Ghosal G Yuan J Chen J Huang J Science (in the press)
- [17]Huang M Mol. Cell (in the press)
Cited by
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“Activation of the BRCA-FA pathway is typically measured by the DNA damage-induced monoubiquitination of FANCD2 and, more recently, FANCI [32].”
- Authors
- Huang, M., & D'Andrea, A. D.
- Affiliations
- Harvard University (US)
- ORCID
- Huang, Min
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-08
- Volume
- 17
- Issue
- 8
- Pages
- 926-928
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC2945811
- OpenAlex
- W2084316239
- Cited by
- 29
- References
- 28
- Citations by year
- 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 6 · 2013: 2 · 2012: 6
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK43889, R01DK043889)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- Fanconi anemia pathway, interstrand cross-links, FANCD2 monoubiquitination, DNA repair, translesion synthesis, protein-protein interaction
- MeSH terms
- Animals, DNA Damage, DNA Repair, Endodeoxyribonucleases, Exodeoxyribonucleases, Fanconi Anemia, Humans, Xenopus, Proliferating Cell Nuclear Antigen, Fanconi Anemia Complementation Group D2 Protein, Ubiquitination, Multifunctional Enzymes
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