Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Abstract
Fanconi anaemia (FA) has recently become an attractive model to study breast cancer susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical to the BRCA genes BRCA2, PALB2 and BRIP1. Increasing evidence shows that FA proteins function as signal transducers and DNA-processing molecules in a DNA-damage response network. This network consists of many proteins that maintain genome integrity, including ataxia telangiectasia and Rad3 related protein (ATR), Bloom syndrome protein (BLM), and BRCA1. Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, I discuss what is known about FA proteins and their interactive network, and what remains to be discovered.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fanconi anemia patient cells are extremely sensitive to agents that induce DNA interstrand crosslinks.
“FA is a rare cancer-prone disease in which patients’ cells are characterized by extreme sensitivity to agents that induce DNA interstrand crosslinks (for review, see [22,23]).”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [23]
Cites
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works
Hallmarks of 'BRCAness' in sporadic cancers
Turner, N. C., Tutt, A. N. J., & Ashworth, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1457 · Cited by 1,651 · see citing works
Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway
Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198 · see citing works
Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia
Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works
BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks
Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007 · see citing works
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Rahman, N., Seal, S., Thompson, D. J., Kelly, P. F., Renwick, A., Elliott, A., Reid, S., Spanova, K., Barfoot, R., Chagtai, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1959 · Cited by 1,002 · see citing works
Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2
Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.022 · Cited by 861 · see citing works
Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA
Kannouche, P. L., Wing, J., & Lehmann, A. R. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00259-x · Cited by 845 · see citing works
BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure
Yang, H., Jeffrey, P. D., Miller, J. J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P., Lee, W., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.297.5588.1837 · Cited by 705 · see citing works
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex
Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695 · see citing works
Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E. R., Hurov, K. E., Luo, J., Ballif, B. A., Gygi, S. P., Hofmann, K., D’Andrea, A. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.009 · Cited by 695 · see citing works
RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites
Sobhian, B., Shao, G., Lilli, D. R., Culhane, A. C., Moreau, L. A., Xia, B., Livingston, D. M., & Greenberg, R. A. (2007) · Science · doi:10.1126/science.1139516 · Cited by 672 · see citing works
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Reid, S., Schindler, D., Hanenberg, H., Barker, K., Hanks, S., Kalb, R., Neveling, K., Kelly, P., Seal, S., Freund, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1947 · Cited by 642 · see citing works
Cloning of cDNAs for Fanconi's anaemia by functional complementation
Strathdee, C. A., Gavish, H., Shannon, W. R., & Buchwald, M. (1992) · Nature · doi:10.1038/356763a0 · Cited by 621 · see citing works
The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway
Nijman, S. M. B., Huang, T. T., Dirac, A. M. G., Brummelkamp, T. R., Kerkhoven, R. M., D’Andrea, A. D., & Bernards, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.008 · Cited by 586 · see citing works
Regulation of monoubiquitinated PCNA by DUB autocleavage
Huang, T. T., Nijman, S. M. B., Mirchandani, K. D., Galardy, P. J., Cohn, M. A., Haas, W., Gygi, S. P., Ploegh, H. L., Bernards, R., & D’Andrea, A. D. (2006) · Nature Cell Biology · doi:10.1038/ncb1378 · Cited by 585 · see citing works
A novel ubiquitin ligase is deficient in Fanconi anemia
Meetei, A. R., de Winter, J. P., Medhurst, A. L., Wallisch, M., Waisfisz, Q., van de Vrugt, H. J., Oostra, A. B., Yan, Z., Ling, C., Bishop, C. E., et al. (2003) · Nature Genetics · doi:10.1038/ng1241 · Cited by 566 · see citing works
Self-citationThe emerging genetic and molecular basis of Fanconi anaemia
Joenje, H., & Patel, K. J. (2001) · Nature Reviews Genetics · doi:10.1038/35076590 · Cited by 566 · see citing works
Repair of DNA interstrand cross-links
Dronkert, M. L. G., & Kanaar, R. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00092-1 · Cited by 557 · see citing works
Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response
Kim, H., Chen, J., & Yu, X. (2007) · Science · doi:10.1126/science.1139621 · Cited by 540 · see citing works
Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors
Taniguchi, T., Tischkowitz, M. D., Ameziane, N., Hodgson, S. V., Mathew, C. G., Joenje, H., Mok, S. C., & D’Andrea, A. D. (2003) · Nature Medicine · doi:10.1038/nm852 · Cited by 537 · see citing works
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Xia, B., Dorsman, J. C., Ameziane, N., de Vries, Y., Rooimans, M. A., Sheng, Q., Pals, G., Errami, A., Gluckman, E., Llera, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1942 · Cited by 465 · see citing works
Self-citationThe Fanconi Anemia/BRCA pathway: new faces in the crowdPreprint
Kennedy, R. D., & D’Andrea, A. D. (2005) · Genes & Development · doi:10.1101/gad.1370505 · Cited by 464 · see citing works
S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
Taniguchi, T., García-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., & D’Andrea, A. D. (2002) · Blood · doi:10.1182/blood-2002-01-0278 · Cited by 458 · see citing works
Meetei, A. R., Medhurst, A. L., Ling, C., Xue, Y., Singh, T. R., Bier, P., Steltenpool, J., Stone, S., Dokal, I. S., Mathew, C. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1626 · Cited by 454 · see citing works
Self-citationConvergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways
Taniguchi, T., García-Higuera, I., Xu, B., Andreassen, P. R., Gregory, R. C., Kim, S., Lane, W. S., Kastan, M. B., & D’Andrea, A. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00747-x · Cited by 447 · see citing works
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J
Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., et al. (2005) · Nature Genetics · doi:10.1038/ng1625 · Cited by 432 · see citing works
BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.
Yuan, S. F., Lee, S. Y., Chen, G., Song, M., Tomlinson, G. E., & Lee, E. Y.-H. P. (1999) · PubMed · Cited by 409 · see citing works
ATR couples FANCD2 monoubiquitination to the DNA-damage responsePreprint
Andreassen, P. R., D’Andrea, A. D., & Taniguchi, T. (2004) · Genes & Development · doi:10.1101/gad.1196104 · Cited by 407 · see citing works
Positional Cloning of a Novel Fanconi Anemia Gene, FANCD2
Timmers, C. D., Taniguchi, T., Hejna, J., Reifsteck, C. A., Lucas, L., Bruun, D. A., Thayer, M., Cox, B., Olson, S. B., D’Andrea, A. D., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00172-1 · Cited by 399 · see citing works
Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
Foe, J. R. L. T., Rooimans, M. A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D. F., Savoia, A., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-320 · Cited by 398 · see citing works
Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair
Nakanishi, K., Yang, Y.-G., Pierce, A. J., Taniguchi, T., Digweed, M., D'Andrea, A. D., Wang, Z.-Q., & Jasin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407796102 · Cited by 384 · see citing works
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370 · see citing works
A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome
Meetei, A. R., Sechi, S., Wallisch, M., Yang, D., Young, M. K., Joenje, H., Hoatlin, M. E., & Wang, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3417-3426.2003 · Cited by 355 · see citing works
Self-citationThe Fanconi anaemia group G gene FANCG is identical with XRCC9
de Winter, J. P., Waisfisz, Q., Rooimans, M. A., van Berkel, C. G. M., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., et al. (1998) · Nature Genetics · doi:10.1038/3093 · Cited by 333 · see citing works
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1
Cobb, J. A., Bjergbæk, L., Shimada, K., Frei, C., & Gasser, S. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg391 · Cited by 333 · see citing works
Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin
Wang, X., Andreassen, P. R., & D’Andrea, A. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5850-5862.2004 · Cited by 332 · see citing works
X-linked inheritance of Fanconi anemia complementation group B
Meetei, A. R., Levitus, M., Xue, Y., Medhurst, A. L., Zwaan, M. C., Chen, L., Rooimans, M. A., Bier, P., Hoatlin, M. E., Pals, G., et al. (2004) · Nature Genetics · doi:10.1038/ng1458 · Cited by 322 · see citing works
Self-citationIdentification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM
Ciccia, A., Ling, C., Coulthard-Graf, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N. Q., de Winter, J. P., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.003 · Cited by 321 · see citing works
Self-citationMultifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works
The Fanconi Anaemia Gene FANCC Promotes Homologous Recombination and Error-Prone DNA Repair
Niedźwiedź, W., Mosedale, G., Johnson, M. A., Ong, C. Y., Pace, P., & Patel, K. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.009 · Cited by 306 · see citing works
UBE2T Is the E2 in the Fanconi Anemia Pathway and Undergoes Negative Autoregulation
Machida, Y., Machida, Y., Chen, Y., Gurtan, A. M., Kupfer, G. M., D’Andrea, A. D., & Dutta, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.024 · Cited by 291 · see citing works
Hanada, K., Budzowska, M., Modesti, M., Maas, A., Wyman, C., Essers, J., & Kanaar, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601344 · Cited by 290 · see citing works
Fanconi Anemia (Cross)linked to DNA Repair
Niedernhofer, L. J., Lalai, A. S., & Hoeijmakers, J. H. J. (2005) · Cell · doi:10.1016/j.cell.2005.12.009 · Cited by 290 · see citing works
Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9
Strathdee, C. A., Duncan, A. M. V., & Buchwald, M. (1992) · Nature Genetics · doi:10.1038/ng0692-196 · Cited by 283 · see citing works
Repair of an Interstrand DNA Cross-link Initiated by ERCC1-XPF Repair/Recombination Nuclease
Kuraoka, I., Kobertz, W. R., Ariza, R. R., Biggerstaff, M., Essigmann, J. M., & Wood, R. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000337200 · Cited by 280 · see citing works
Positional cloning of the Fanconi anaemia group A gene
Apostolou, S., Whitmore, S. A., Crawford, J., Lennon, G. G., Sutherland, G. R., Callen, D. F., lanzano, L., Savino, M., D’Apolito, M., Notarangeio, A., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-324 · Cited by 277 · see citing works
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway
Sims, A. E., Spiteri, E., Sims, R. J., Arita, A., Lach, F. P., Landers, T., Wurm, M., Freund, M., Neveling, K., Hanenberg, H., et al. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1252 · Cited by 275 · see citing works
Interaction of FANCD2 and NBS1 in the DNA damage response
Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H. V., Moreau, L. A., Stotsky, M., Mathew, C. G., Kastan, M. B., Weaver, D. T., & D’Andrea, A. D. (2002) · Nature Cell Biology · doi:10.1038/ncb879 · Cited by 270 · see citing works
The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
de Winter, J. P., Rooimans, M. A., van der Weel, L., van Berkel, C. G. M., Alon, N., Bosnoyan-Collins, L., de Groot, J., Zhi, Y., Waisfisz, Q., Pronk, J. C., et al. (2000) · Nature Genetics · doi:10.1038/71626 · Cited by 264 · see citing works
Fanconi anemia gene mutations in young-onset pancreatic cancer.
van der Heijden, M. S., Yeo, C. J., Hruban, R. H., & Kern, S. E. (2003) · PubMed · Cited by 262 · see citing works
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout micePreprint
Houghtaling, S. R., Timmers, C. D., Noll, M., Finegold, M. J., Jones, S. N., Meyn, M. S., & Grompe, M. (2003) · Genes & Development · doi:10.1101/gad.1103403 · Cited by 262 · see citing works
Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240 · see citing works
Fanconi Anemia Proteins FANCA, FANCC, and FANCG/XRCC9 Interact in a Functional Nuclear Complex
García-Higuera, I., Kuang, Y., Näf, D., Wasik, J., & D’Andrea, A. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4866 · Cited by 227 · see citing works
The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways
Pichierri, P., & Rosselli, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600113 · Cited by 222 · see citing works
Isolation of a cDNA Representing the Fanconi Anemia Complementation Group E Gene
de Winter, J. P., Léveillé, F., van Berkel, C. G. M., Rooimans, M. A., van der Weel, L., Steltenpool, J., Demuth, I., Morgan, N. V., Alon, N., Bosnoyan-Collins, L., et al. (2000) · The American Journal of Human Genetics · doi:10.1016/s0002-9297(07)62959-0 · Cited by 221 · see citing works
POLQ (Pol ), a DNA polymerase and DNA-dependent ATPase in human cells
Seki, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg814 · Cited by 213 · see citing works
Bridge, W. L., Vandenberg, C. J., Franklin, R., & Hiom, K. J. (2005) · Nature Genetics · doi:10.1038/ng1627 · Cited by 208 · see citing works
Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway
Chirnomas, D., Taniguchi, T., de la Vega, M., Vaidya, A. P., Vasserman, M., Hartman, A., Kennedy, R. D., Foster, R., Mahoney, J., Seiden, M. V., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0493 · Cited by 204 · see citing works
Tracing the network connecting brca and fanconi anaemia proteins
Venkitaraman, A. R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1321 · Cited by 196 · see citing works
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG
de Winter, J. P. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.18.2665 · Cited by 194 · see citing works
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
Mosedale, G., Niedźwiedź, W., Alpi, A. F., Perrina, F., Pereira‐Leal, J. B., Johnson, M. A., Langevin, F., Pace, P., & Patel, K. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb981 · Cited by 191 · see citing works
Nojima, K., Hochegger, H., Saberi, A., Fukushima, T., Kikuchi, K., Yoshimura, M., Orelli, B. J., Bishop, D. K., Hirano, S., Ohzeki, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1214 · Cited by 185 · see citing works
The Fanconi anaemia proteins, FAA and FAC interact to form a nuclear complex
Kupfer, G. M., Näf, D., Suliman, A., Pulsipher, M. A., & D’Andrea, A. D. (1997) · Nature Genetics · doi:10.1038/ng1297-487 · Cited by 184 · see citing works
The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells
Peng, M., Litman, R., Xie, J., Sharma, S., Brosh, R. M., & Cantor, S. B. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601754 · Cited by 181 · see citing works
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
Yin, J., Sobeck, A., Xu, C., Meetei, A. R., Hoatlin, M. E., Li, L., & Wang, W. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600622 · Cited by 180 · see citing works
Self-citationFANCE: the link between Fanconi anaemia complex assembly and activity
Pace, P., Johnson, M., Tan, W. M., Mosedale, G., Sng, C. C. A., Hoatlin, M., de Winter, J. P., Joenje, H., Gergely, F. V., & Patel, K. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf355 · Cited by 172 · see citing works
Nbs1 is required for ATR‐dependent phosphorylation events
Stiff, T., Reis, C., Alderton, G. K., Woodbine, L. J., O’Driscoll, M., & Jeggo, P. A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600504 · Cited by 169 · see citing works
FAAP100 is essential for activation of the Fanconi anemia‐associated DNA damage response pathway
Ling, C., Ishiai, M., Ali, A. M., Medhurst, A. L., Neveling, K., Kalb, R., Yan, Z., Xue, Y., Oostra, A. B., Auerbach, A. D., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601666 · Cited by 167 · see citing works
Self-citationDirect interactions of the five known Fanconi anaemia proteins suggest a common functional pathway
Medhurst, A. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.423 · Cited by 157 · see citing works
Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J. E., Buerstedde, J.-M., Tanimoto, M., Harada, M., Thompson, L. H., & Takata, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5421-5430.2003 · Cited by 150 · see citing works
Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway
Wang, X., Kennedy, R. D., Ray, K., Stuckert, P., Ellenberger, T., & D’Andrea, A. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02357-06 · Cited by 147 · see citing works
Shima, N., Munroe, R. J., & Schimenti, J. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10381-10389.2004 · Cited by 144 · see citing works
Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
Bjergbæk, L., Cobb, J. A., Tsai-Pflugfelder, M., & Gasser, S. M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600511 · Cited by 141 · see citing works
Kalb, R., Neveling, K., Hoehn, H., Schneider, H., Linka, Y., Batish, S. D., Hunt, C., Berwick, M., Callén, E., Surrallés, J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/517616 · Cited by 139 · see citing works
A FancD2-Monoubiquitin Fusion Reveals Hidden Functions of Fanconi Anemia Core Complex in DNA Repair
Matsushita, N., Kitao, H., Ishiai, M., Nagashima, N., Hirano, S., Okawa, K., Ohta, T., Yu, D. S., McHugh, P. J., Hickson, I. D., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.018 · Cited by 138 · see citing works
Identification of the Fanconi Anemia Complementation Group I Gene, FANCI
Dorsman, J. C., Levitus, M., Rockx, D., Rooimans, M. A., Oostra, A. B., Haitjema, A., Bakker, S. T., Steltenpool, J., Schuler, D., Mohan, S., et al. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/151968 · Cited by 133 · see citing works
The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation
Yamashita, T., Kupfer, G. M., Näf, D., Suliman, A., Joenje, H., Asano, S., & D’Andrea, A. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13085 · Cited by 129 · see citing works
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
Bogliolo, M., Lyakhovich, A., Callén, E., Castellà, M., Cappelli, E., Ramı́rez, M. J., Creus, A., Marcos, R., Kalb, R., Neveling, K., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601574 · Cited by 128 · see citing works
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM
Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y. M., Arakawa, H., Buerstedde, J.-M., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600534 · Cited by 125 · see citing works
Harris, P. V., Mazina, O. M., Leonhardt, E. A., Case, R. B., Boyd, J. B., & Burtis, K. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5764 · Cited by 125 · see citing works
Phosphorylation of FANCD2 on Two Novel Sites Is Required for Mitomycin C Resistance
Ho, G. P. H., Margossian, S. P., Taniguchi, T., & D’Andrea, A. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02018-05 · Cited by 118 · see citing works
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Collis, S. J., Barber, L. J., Clark, A. J., Martin, J. S., Ward, J. D., & Boulton, S. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1555 · Cited by 112 · see citing works
The Fanconi Anemia Pathway of Genomic Maintenance
Levitus, M., Joenje, H., & de Winter, J. P. (2006) · Analytical Cellular Pathology · doi:10.1155/2006/974975 · Cited by 106 · see citing works
How Fanconi anemia proteins promote the four Rs: Replication, recombination, repair, and recovery
Thompson, L. H., Hinz, J. M., Yamada, N. A., & Jones, N. J. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20109 · Cited by 104 · see citing works
Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands
Guy, C. P. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki685 · Cited by 104 · see citing works
FANCL Replaces BRCA1 as the Likely Ubiquitin Ligase Responsible for FANCD2 Monoubiquitination
Meetei, A. R., Yan, Z., & Wang, W. (2004) · Cell Cycle · doi:10.4161/cc.3.2.656 · Cited by 101 · see citing works
Self-citationShen, X. H., Jun, S., O'Neal, L. E., Sonoda, E., Bemark, M., Sale, J. E., & Li, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600071200 · Cited by 97 · see citing works
Novel endonuclease in Archaea cleaving DNA with various branched structure.
Komori, K., Fujikane, R., Shinagawa, H., & Ishino, Y. (2002) · Genes & Genetic Systems · doi:10.1266/ggs.77.227 · Cited by 96 · see citing works
Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de Winter, J. P., Wallisch, M., Akkari, Y. M. N., Olson, S. B., Wang, W., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.425-437.2006 · Cited by 92 · see citing works
Self-citationKomori, K., Hidaka, M., Horiuchi, T., Fujikane, R., Shinagawa, H., & Ishino, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409243200 · Cited by 91 · see citing works
Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia
Tischkowitz, M. D., Morgan, N. V., Grimwade, D. J., Eddy, C.-A., Ball, S. E., Vořechovský, I., Langabeer, S. E., Stöger, R. J., Hodgson, S. V., & Mathew, C. G. (2004) · Leukemia · doi:10.1038/sj.leu.2403280 · Cited by 88 · see citing works
Prakash, R., Krejčí, L., Komen, S. V., Schürer, K. A., Kramer, W., & Sung, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413898200 · Cited by 82 · see citing works
Godthelp, B. C., Wiegant, W. W., Waisfisz, Q., Medhurst, A. L., Arwert, F., Joenje, H., & Zdzienicka, M. Z. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.07.008 · Cited by 75 · see citing works
Identification of a Fanconi anemia complementation group I gene, FANCI.
Dorsman, J., Levitus, M., Rockx, D., Rooimans, M., Oostra, A., Haitjema, A., Bakker, S., Steltenpool, J., Schuler, D., Mohan, S., et al. (2007) · Pure Amsterdam UMC · Cited by 75 · see citing works
The 4N Cell Cycle Delay in Fanconi Anemia Reflects Growth Arrest in Late S Phase
Akkari, Y. M. N., Bateman, R. L., Reifsteck, C. A., D’Andrea, A. D., Olson, S. B., & Grompe, M. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3259 · Cited by 73 · see citing works
Direct DNA Binding Activity of the Fanconi Anemia D2 Protein
Park, W.-H., Margossian, S. P., Horwitz, A. A., Simons, A. M., D’Andrea, A. D., & Parvin, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503730200 · Cited by 70 · see citing works
Li, L., Peterson, C. A., Lu, X., Wei, P. Y., & Legerski, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5619 · Cited by 65 · see citing works
Lichtman, M. A., Spivak, J. L., Boxer, L. A., Shattil, S. J., & HENDERSON, E. (2000) · Elsevier eBooks · doi:10.1016/b978-012448510-5/50106-0 · Cited by 57 · see citing works
DNA Interstrand Cross-Link Repair in the Cell Cycle: A Critical Role for Polymerase ζ in G1 Phase
McHugh, P. J., & Sarkar, S. (2006) · Cell Cycle · doi:10.4161/cc.5.10.2763 · Cited by 54 · see citing works
The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly
Gurtan, A. M., Stuckert, P., & D’Andrea, A. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511411200 · Cited by 53 · see citing works
Qiao, F., Mi, J., Wilson, J. B., Zhi, G., Bucheimer, N. R., Jones, N. J., & Kupfer, G. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408323200 · Cited by 46 · see citing works
DNA Structure-Induced Recruitment and Activation of the Fanconi Anemia Pathway Protein FANCD2
Sobeck, A., Stone, S., & Hoatlin, M. E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02196-06 · Cited by 39 · see citing works
Analysis of the Fanconi Anaemia Complentation Group A Gene in Acute Myeloid Leukaemia
Condie, A., Powles, R., Hudson, C. D., Shepherd, V., Bevan, S., Yuille, M., & Houlston, R. S. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819021000009274 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
McVey, M., & Lee, S. E. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.08.007 · Cited by 974 · see citing works
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works
Nonproteolytic Functions of Ubiquitin in Cell Signaling
Chen, Z. J., & Sun, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.014 · Cited by 921 · see citing works
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786 · see citing works
Meindl, A., Hellebrand, H., Wiek, C., Erven, V., Wappenschmidt, B., Niederacher, D., Freund, M., Lichtner, P., Hartmann, L., Schaal, H., et al. (2010) · Nature Genetics · doi:10.1038/ng.569 · Cited by 743 · see citing works
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
Raya, Á., Rodríguez-Pizà, I., Güenechea, G., Vassena, R., Navarro, S., Barrero, M. J., Consiglio, A., Castellà, M., Rı́o, P., Sleep, E., et al. (2009) · Nature · doi:10.1038/nature08129 · Cited by 690 · see citing works
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, P. M., Griffiths, M. R., Long, J. M., Charrier, J.-D., MacCormick, S., Charlton, P. A., Golec, J. M. C., & Pollard, J. R. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.573 · Cited by 633 · see citing works
Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
Chen, C., Ferreira, J. C. B., Gross, E. R., & Mochly‐Rosen, D. (2014) · Physiological Reviews · doi:10.1152/physrev.00017.2013 · Cited by 613 · see citing works
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Sy, S. M.-H., Huen, M. S. Y., & Chen, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811159106 · Cited by 607 · see citing works
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
Chan, K., Palmai‐Pallag, T., Ying, S., & Hickson, I. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1882 · Cited by 601 · see citing works
Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., & Passegué, E. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.014 · Cited by 599 · see citing works
How the Fanconi Anemia Pathway Guards the Genome
Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 586 · see citing works
PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response
Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 556 · see citing works
Pathophysiology and management of inherited bone marrow failure syndromes
Shimamura, A., & Alter, B. P. (2010) · Blood Reviews · doi:10.1016/j.blre.2010.03.002 · Cited by 556 · see citing works
The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
Knipscheer, P., Räschle, M., Smogorzewska, A., Enoiu, M., Ho, T. V., Schärer, O. D., Elledge, S. J., & Walter, J. C. (2009) · Science · doi:10.1126/science.1182372 · Cited by 515 · see citing works
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint
Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 510 · see citing works
Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
Räschle, M., Knipscheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J. D., Ellenberger, T., Schärer, O. D., & Walter, J. C. (2008) · Cell · doi:10.1016/j.cell.2008.08.030 · Cited by 507 · see citing works
BRCA1 and its toolbox for the maintenance of genome integrity
Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 495 · see citing works
HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
Gordan, J. D., Lal, P., Dondeti, V. R., Letrero, R., Parekh, K. N., Oquendo, C. E., Greenberg, R. A., Flaherty, K. T., Rathmell, W. K., Keith, B., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.016 · Cited by 493 · see citing works
Susceptibility Pathways in Fanconi's Anemia and Breast Cancer
D’Andrea, A. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0809889 · Cited by 380 · see citing works
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
Schwab, R. A., Nieminuszczy, J., Shah, F., Langton, J., Martínez, D. L., Liang, C., Cohn, M. A., Gibbons, R. J., Deans, A. J., & Niedźwiedź, W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.012 · Cited by 356 · see citing works
Naim, V., & Rosselli, F. (2009) · Nature Cell Biology · doi:10.1038/ncb1883 · Cited by 335 · see citing works
Collaboration and competition between DNA double‐strand break repair pathways
Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326 · see citing works
Hereditary breast cancer: new genetic developments, new therapeutic avenues
Campeau, P. M., Foulkes, W. D., & Tischkowitz, M. D. (2008) · Human Genetics · doi:10.1007/s00439-008-0529-1 · Cited by 318 · see citing works
MacKay, C., Déclais, A., Lundin, C., Agostinho, A., Deans, A. J., Macartney, T., Hofmann, K., Gartner, A., West, S. C., Helleday, T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.021 · Cited by 311 · see citing works
Expanded roles of the Fanconi anemia pathway in preserving genomic stabilityPreprint
Kee, Y., & D’Andrea, A. D. (2010) · Genes & Development · doi:10.1101/gad.1955310 · Cited by 309 · see citing works
PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2
Zhang, F., Fan, Q., Ren, K., & Andreassen, P. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0123 · Cited by 303 · see citing works
Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia
Adamo, A., Collis, S. J., Adelman, C. A., Silva, N., Hořejšı́, Z., Ward, J. D., Martínez-Pérez, E., Boulton, S. J., & Volpe, A. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.026 · Cited by 297 · see citing works
Molecular pathogenesis and clinical management of Fanconi anemia
Kee, Y., & D’Andrea, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58321 · Cited by 284 · see citing works
Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype
Sawyer, S. L., Tian, L., Kähkönen, M., Schwartzentruber, J., Kircher, M., Majewski, J., Dyment, D. A., Innes, A. M., Boycott, K. M., Moreau, L. A., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1156 · Cited by 282 · see citing works
Ubiquitin signalling in DNA replication and repair
Ulrich, H. D., & Walden, H. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2921 · Cited by 272 · see citing works
Kratz, K., Schöpf, B., Kaden, S., Sendoel, A., Eberhard, R., Lademann, C. A., Cannavò, E., Sartori, A. A., Hengartner, M. O., & Jiricny, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.022 · Cited by 271 · see citing works
Strub, T., Giuliano, S., Ye, T., Bonet, C., Keime, C., Kobi, D., Le Gras, S., Cormont, M., Ballotti, R., Bertolotto, C., et al. (2011) · Oncogene · doi:10.1038/onc.2010.612 · Cited by 269 · see citing works
A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses
Liang, Q., Dexheimer, T. S., Zhang, P., Rosenthal, A. S., Villamil, M. A., You, C., Zhang, Q., Chen, J., Ott, C. A., Sun, H., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1455 · Cited by 264 · see citing works
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Bunting, S. F., Callén, E., Kozak, M. L., Kim, J. M., Wong, N., López-Contreras, A. J., Ludwig, T., Baer, R., Faryabi, R. B., Malhowski, A., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.015 · Cited by 252 · see citing works
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair
Liu, T., Ghosal, G., Yuan, J., Chen, J., & Huang, J. (2010) · Science · doi:10.1126/science.1192656 · Cited by 250 · see citing works
Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype
Kim, J. M., Parmar, K., Huang, M., Weinstock, D. M., Ruit, C. A., Kutok, J. L., & D’Andrea, A. D. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.001 · Cited by 246 · see citing works
Yan, Z., Delannoy, M., Chen, L., Daee, D. L., Osman, F., Muniandy, P. A., Shen, X. H., Oostra, A. B., Du, H., Steltenpool, J., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.039 · Cited by 242 · see citing works
Self-citationIdentification of Novel Epstein-Barr Virus MicroRNA Genes from Nasopharyngeal Carcinomas
Zhu, J. Y., Pfuhl, T., Motsch, N., Barth, S., Nicholls, J. M., Grässer, F. A., & Meister, G. (2009) · Journal of Virology · doi:10.1128/jvi.01689-08 · Cited by 240 · see citing works
Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
Long, D. T., Räschle, M., Joukov, V., & Walter, J. C. (2011) · Science · doi:10.1126/science.1204258 · Cited by 238 · see citing works
Remodeling of DNA replication structures by the branch point translocase FANCM
Gari, K., Décaillet, C., Delannoy, M., Wu, L., & Constantinou, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804777105 · Cited by 234 · see citing works
The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder
Walden, H., & Deans, A. J. (2014) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-051013-022737 · Cited by 229 · see citing works
Beyond BRCA: New hereditary breast cancer susceptibility genes
Economopoulou, P., Dimitriadis, G., & Psyrri, A. K. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2014.10.008 · Cited by 226 · see citing works
The ubiquitous role of ubiquitin in the DNA damage response
Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 224 · see citing works
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita‐Kikuta, E., Koike, T., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1504 · Cited by 222 · see citing works
Chen, J., Dexheimer, T. S., Ai, Y., Liang, Q., Villamil, M. A., Inglese, J., Maloney, D. J., Jadhav, A., Simeonov, A. M., & Zhuang, Z. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.08.014 · Cited by 217 · see citing works
Breast cancer susceptibility: current knowledge and implications for genetic counselling
Ripperger, T., Gadzicki, D., Meindl, A., & Schlegelberger, B. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.212 · Cited by 212 · see citing works
Thompson, E. R., Doyle, M., Ryland, G. L., Rowley, S. M., Choong, D. Y. H., Tothill, R. W., Thorne, H., kConFab, Barnes, D. R., Li, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002894 · Cited by 211 · see citing works
Collis, S. J., Ciccia, A., Deans, A. J., Hořejšı́, Z., Martin, J. S., Maslen, S., Skehel, M. J., Elledge, S. J., West, S. C., & Boulton, S. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.014 · Cited by 210 · see citing works
ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
Huntoon, C. J., Flatten, K. S., Hendrickson, A. E. W., Huehls, A. M., Sutor, S. L., Kaufmann, S. H., & Karnitz, L. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0110 · Cited by 205 · see citing works
Linking the Cellular Functions ofBRCAGenes to Cancer Pathogenesis and Treatment
Venkitaraman, A. R. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.151422 · Cited by 199 · see citing works
Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI
Alpi, A. F., Pace, P., Babu, M. M., & Patel, K. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.003 · Cited by 192 · see citing works
Mechanism and regulation of incisions during DNA interstrand cross-link repair
Zhang, J., & Walter, J. C. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.018 · Cited by 187 · see citing works
DNA damage response – A double-edged sword in cancer prevention and cancer therapy
Tian, H., Gao, Z., Li, H., Zhang, B., Wang, G., Zhang, Q., Pei, D., & Zheng, J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.038 · Cited by 186 · see citing works
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works
Inherited bone marrow failure syndromes
Dokal, I. S., & Vulliamy, T. (2010) · Haematologica · doi:10.3324/haematol.2010.025619 · Cited by 173 · see citing works
Targeting the DNA Damage Response in Cancer
Ljungman, M. E. (2009) · Chemical Reviews · doi:10.1021/cr900047g · Cited by 163 · see citing works
BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control
Gong, Z., Kim, J.-E., Leung, C. C. Y., Glover, J. N. M., & Chen, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.002 · Cited by 160 · see citing works
Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies
Toft, D. J., & Cryns, V. L. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0164 · Cited by 160 · see citing works
Chen, Y.-H., Jones, M. V., Yin, Y., Crist, S. B., Colnaghi, L., Sims, R. J., Rothenberg, E., Jallepalli, P. V., & Huang, T. T. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.031 · Cited by 158 · see citing works
Iacobuzio–Donahue, C. A. (2011) · Gut · doi:10.1136/gut.2010.236026 · Cited by 158 · see citing works
ATR activation and replication fork restart are defective in FANCM‐deficient cells
Schwab, R. A., Blackford, A. N., & Niedźwiedź, W. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.385 · Cited by 155 · see citing works
Thompson, L. H., & Hinz, J. M. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.02.003 · Cited by 154 · see citing works
Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair
Tam, L. M., Price, N. E., & Wang, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00464 · Cited by 153 · see citing works
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
Joo, W. S., Xu, G., Persky, N. S., Smogorzewska, A., Rudge, D. G., Buzovetsky, O., Elledge, S. J., & Pavletich, N. P. (2011) · Science · doi:10.1126/science.1205805 · Cited by 149 · see citing works
Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M
Bakker, S. T., van de Vrugt, H. J., Rooimans, M. A., Oostra, A. B., Steltenpool, J., Delzenne‐Goette, E., van der Wal, A., van der Valk, M., Joenje, H., Riele, H. T., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp297 · Cited by 148 · see citing works
Sun, W., Nandi, S., Osman, F., Ahn, J. S., Jakovleska, J., Lorenz, A., & Whitby, M. C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.024 · Cited by 147 · see citing works
Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling
Beck, A. H., Lee, C.-H., Witten, D., Gleason, B., Edris, B., Espinosa, Í., Zhu, S., Li, R., Montgomery, K. D., Marinelli, R. J., et al. (2009) · Oncogene · doi:10.1038/onc.2009.381 · Cited by 147 · see citing works
Genomic profiling of breast tumours in relation to BRCAabnormalities and phenotypes
Stefánsson, Ó. A., Jonasson, J. G., Jóhannsson, Ó. Þ., Ólafsdóttir, K., Steinarsdóttir, M., Valgeirsdóttir, S., & Eyfjord, J. E. (2009) · Breast Cancer Research · doi:10.1186/bcr2334 · Cited by 145 · see citing works
Histone Modifications and DNA Double-Strand Break Repair after Exposure to Ionizing Radiations
Hunt, C. R., Ramnarain, D. B., Horikoshi, N., Iyengar, P., PANDITA, R. K., Shay, J. W., & Pandita, T. K. (2013) · Radiation Research · doi:10.1667/rr3308.2 · Cited by 144 · see citing works
Genotype–phenotype correlations in Fanconi anemia
Neveling, K., Endt, D., Hoehn, H., & Schindler, D. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.05.006 · Cited by 144 · see citing works
Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact
Castellà, M., Pujol, R. M., Callén, E., Ramı́rez, M. J., Casado, J. A., Talavera, M., Ferró, T., Muñoz, A. D. A., Sevilla, J., Madero, L., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.084210 · Cited by 143 · see citing works
Ubiquitin-binding domains and their role in the DNA damage response
Hofmann, K. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.003 · Cited by 142 · see citing works
Lattmann, S., Giri, B., Vaughn, J. P., Akman, S. A., & Nagamine, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq372 · Cited by 138 · see citing works
What is the DNA repair defect underlying Fanconi anemia?
Duxin, J. P., & Walter, J. C. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.09.002 · Cited by 136 · see citing works
Singh, T. R., Bakker, S. T., Agarwal, S., Jansen, M., Grassman, E., Godthelp, B. C., Ali, A. M., Du, C.-H., Rooimans, M. A., Fan, Q., et al. (2009) · Blood · doi:10.1182/blood-2009-02-207811 · Cited by 135 · see citing works
Wagner, J. M., & Karnitz, L. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.055178 · Cited by 135 · see citing works
The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response
Huang, M., Kim, J. M., Shiotani, B., Yang, K., Zou, L., & D’Andrea, A. D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.005 · Cited by 134 · see citing works
Molecular Mechanisms of Human Papillomavirus-Induced Carcinogenesis
Lehoux, M., D’Abramo, C. M., & Archambault, J. (2009) · Public Health Genomics · doi:10.1159/000214918 · Cited by 133 · see citing works
Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations
Castellà, M., Pujol, R. M., Callén, E., Trujillo‐Quintero, J. P., Casado, J. A., Gille, H., Lach, F. P., Auerbach, A. D., Schindler, D., Benitez, J. J., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299917 · Cited by 133 · see citing works
The ubiquitin landscape at DNA double-strand breaks
Messick, T. E., & Greenberg, R. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200908074 · Cited by 130 · see citing works
Translesion DNA synthesis polymerases in DNA interstrand crosslink repair
Ho, T. V., & Schärer, O. D. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20573 · Cited by 126 · see citing works
Targeting the ubiquitin‐proteasome system for cancer therapy
Yang, Y., Kitagaki, J., Wang, H., Hou, D., & Perantoni, A. O. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.01013.x · Cited by 124 · see citing works
Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology
Monnat, R. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.002 · Cited by 122 · see citing works
FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair
Xue, Y., Li, Y., Guo, R., Ling, C., & Wang, W. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn054 · Cited by 121 · see citing works
Self-citationLattmann, S., Stadler, M. B., Vaughn, J. P., Akman, S. A., & Nagamine, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr630 · Cited by 120 · see citing works
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy
Górecki, L., Andrš, M., Řezáčová, M., & Korábečný, J. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107518 · Cited by 120 · see citing works
RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer
Somyajit, K., Subramanya, S., & Nagaraju, G. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq210 · Cited by 119 · see citing works
Targeting DNA repair mechanisms in cancer
Furgason, J. M., & Bahassi, E. M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.10.009 · Cited by 118 · see citing works
Bagnyukova, T., Serebriiskii, I. G., Zhou, Y., Hopper-Borge, E. A., Golemis, E. A., & Astsaturov, I. A. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.9.13738 · Cited by 118 · see citing works
Fanconi Anemia Signaling and Cancer
Nepal, M. K., Che, R., Zhang, J., Ma, C., & Fei, P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.10.005 · Cited by 117 · see citing works
Links between genome integrity and BRCA1 tumor suppression
Covington, M. L., & Greenberg, R. A. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.007 · Cited by 116 · see citing works
Assembly of checkpoint and repair machineries at DNA damage sites
Huen, M. S. Y., & Chen, J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.001 · Cited by 116 · see citing works
CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
Chen, C. C., Kennedy, R. D., Sidi, S., Look, A. T., & D’Andrea, A. D. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-24 · Cited by 115 · see citing works
Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies
Puigvert, J. C., Sanjiv, K., & Helleday, T. (2015) · FEBS Journal · doi:10.1111/febs.13574 · Cited by 114 · see citing works
Bryant, C., Rawlinson, R., & Massey, A. J. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-570 · Cited by 114 · see citing works
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1
Parmar, K., Kim, J., Sykes, S. M., Shimamura, A., Stuckert, P., Zhu, K., Hamilton, A., Deloach, M. K., Kutok, J. L., Akashi, K., et al. (2010) · Stem Cells · doi:10.1002/stem.437 · Cited by 113 · see citing works
Sommers, J. A., Rawtani, N., Gupta, R., Bugreev, D. V., Mazin, A. V., Cantor, S. B., & Brosh, R. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809019200 · Cited by 112 · see citing works
The BLM dissolvasome in DNA replication and repair
Manthei, K. A., & Keck, J. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1325-1 · Cited by 111 · see citing works
- Authors
- Wang, W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wang, Weidong
- ORCID
- Wang, Weidong
- Venue
- Nature Reviews Genetics
- Published
- 2007-10
- Volume
- 8
- Issue
- 10
- Pages
- 735-748
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2010216792
- Cited by
- 663
- References
- 107
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 10 · 2020: 17 · 2019: 20 · 2018: 12 · 2017: 28 · 2016: 24 · 2015: 31 · 2014: 40 · 2013: 52 · 2012: 52
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- Fanconi anemia, BRCA genes, DNA damage response, genome stability, BRCA2, FANCJ, FANCI, PALB2, BRIP1, ATR, Bloom syndrome protein, BRCA1, signal transduction, DNA repair, breast cancer susceptibility
- MeSH terms
- Fanconi Anemia Complementation Group N Protein, Animals, Chromatin, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fanconi Anemia, Humans, Nuclear Proteins, Signal Transduction, RNA Helicases, BRCA2 Protein, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Fanconi Anemia Complementation Group Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review