Cited by 663DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

Wang, Weidong·2007·Nature Reviews Genetics

Abstract

Fanconi anaemia (FA) has recently become an attractive model to study breast cancer susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical to the BRCA genes BRCA2, PALB2 and BRIP1. Increasing evidence shows that FA proteins function as signal transducers and DNA-processing molecules in a DNA-damage response network. This network consists of many proteins that maintain genome integrity, including ataxia telangiectasia and Rad3 related protein (ATR), Bloom syndrome protein (BLM), and BRCA1. Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, I discuss what is known about FA proteins and their interactive network, and what remains to be discovered.

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Crossref · 10.1038/nrg2159

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  • Fanconi anemia patient cells are extremely sensitive to agents that induce DNA interstrand crosslinks.

    “FA is a rare cancer-prone disease in which patients’ cells are characterized by extreme sensitivity to agents that induce DNA interstrand crosslinks (for review, see [22,23]).”

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Authors
Wang, W.
Affiliations
National Institutes of Health (US)
Corresponding author
Wang, Weidong
Venue
Nature Reviews Genetics
Published
2007-10
Volume
8
Issue
10
Pages
735-748
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2010216792
Cited by
663
References
107
Citations by year
2026: 6 · 2025: 9 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 10 · 2020: 17 · 2019: 20 · 2018: 12 · 2017: 28 · 2016: 24 · 2015: 31 · 2014: 40 · 2013: 52 · 2012: 52
FWCI
6.87
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords
Fanconi anemia, BRCA genes, DNA damage response, genome stability, BRCA2, FANCJ, FANCI, PALB2, BRIP1, ATR, Bloom syndrome protein, BRCA1, signal transduction, DNA repair, breast cancer susceptibility
MeSH terms
Fanconi Anemia Complementation Group N Protein, Animals, Chromatin, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fanconi Anemia, Humans, Nuclear Proteins, Signal Transduction, RNA Helicases, BRCA2 Protein, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Fanconi Anemia Complementation Group Proteins

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