The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats
Open accessAbstract
BRCA2 has an essential function in DNA repair by homologous recombination, interacting with RAD51 via short motifs in the middle and at the C terminus of BRCA2. Here, we report that a conserved 36-residue sequence of human BRCA2 encoded by exon 27 (BRCA2Exon27) interacts with RAD51 through the specific recognition of oligomerized RAD51 ATPase domains. BRCA2Exon27 binding stabilizes the RAD51 nucleoprotein filament against disassembly by BRC repeat 4. The protection is specific for RAD51 filaments formed on single-stranded DNA and is lost when BRCA2Exon27 is phosphorylated on Ser3291. We propose that productive recombination results from the functional balance between the different RAD51-binding modes of the BRC repeat and exon 27 regions of BRCA2. Our results further suggest a mechanism in which CDK phosphorylation of BRCA2Exon27 at the G2-M transition alters the balance in favor of RAD51 filament disassembly, thus terminating recombination.
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Citations
Cites
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex
Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704
Self-citationCrystal structure of a Rad51 filament
Conway, A. B., Lynch, T. W., Zhang, Y., Fortin, G. S., Fung, C. W., Symington, L. S., & Rice, P. A. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb795 · Cited by 310
Cited by
Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,255
Resistance to therapy caused by intragenic deletion in BRCA2
Edwards, S. L., Brough, R., Lord, C. J., Natrajan, R., Vatcheva, R., Levine, D. A., Boyd, J., Reis-Filho, J. S., & Ashworth, A. (2008) · Nature · doi:10.1038/nature06548 · Cited by 1,011
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
DNA Repair in Mammalian Cells: DNA double-strand break repair: how to fix a broken relationship
Pardo, B., Gómez-González, B., & Aguilera, A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8740-3 · Cited by 280
Metadata
- Authors
- Davies, O. R., & Pellegrini, L.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2007-05-21
- Volume
- 14
- Issue
- 6
- Pages
- 475-483
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W1990772378
- Cited by
- 225
- References
- 2
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Davies, O. R., & Pellegrini, L. (2007). Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb1251
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