The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
DNA Repair in Mammalian Cells: DNA double-strand break repair: how to fix a broken relationship
Abstract
DNA double-strand breaks (DSBs) arise in cells from endogenous and exogenous attacks on the DNA backbone, but also as a direct consequence of replication failures. Proper repair of all these DSBs is essential for genome stability. Repair of broken chromosomes is a challenge for dividing cells that need to distribute equal genetic information to daughter cells. Consequently, eukaryotic organisms have evolved multi-potent and efficient mechanisms to repair DSBs that are primarily divided into two types of pathways: nonhomologous end joining (NHEJ) and homologous recombination (HR). Here we briefly describe how eukaryotic cells sense DSBs and trigger cell cycle arrest to allow repair, and we review the mechanisms of both NHEJ and HR pathways and the choice between them. (Part of a Multi-author Review).
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HDR requires a DNA template containing the sequence to be delivered to the cell, along with Cas9 and the gRNA.
“Contrarily to NHEJ, HDR requires a DNA template containing the sequence to be delivered to the cell, along with Cas9 and the gRNA [71,72].”
From CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool (2019) · cites this paper as [72]
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Cites
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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
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TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends
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Polymerases in nonhomologous end joining: Building a bridge over broken chromosomes
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Genetics and Genomics of Single-Gene Cardiovascular Diseases
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Metadata
- Authors
- Pardo, B., Gómez-González, B., & Aguilera, A.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-01-21
- Volume
- 66
- Issue
- 6
- Pages
- 1039-1056
- ISSN
- 1420-682X
- 1420-9071
- Cited by
- 280
- References
- 10
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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