tRNA selection and kinetic proofreading in translation

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Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity

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The Molecular Basis of Antibiotic Action

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Recognition of Cognate Transfer RNA by the 30 <i>S</i> Ribosomal Subunit

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The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit

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Ribosome Structure and the Mechanism of Translation

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High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic Eubacterium

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Structure of the A Site of <i>Escherichia coli</i> 16 <i>S</i> Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

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Kinetic amplification of enzyme discrimination

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Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form

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Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

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tRNA dynamics on the ribosome during translation

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Errors and alternatives in reading the universal genetic code

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Complete kinetic mechanism of elongation factor Tu‐dependent binding of aminoacyl‐tRNA to the A site of the E.coli ribosome

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Kinetic determinants of high-fidelity tRNA discrimination on the ribosome.

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Insights into the decoding mechanism from recent ribosome structures

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Requirement of an Escherichia coli 50 S Ribosomal Protein Component for Effective Interaction of the Ribosome with T and G Factors and with Guanosine Triphosphate

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Induced fit in initial selection and proofreading of aminoacyl‐tRNA on the ribosome

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Fidelity of Aminoacyl-tRNA Selection on the Ribosome: Kinetic and Structural Mechanisms

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Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

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Cryo‐EM reveals an active role for aminoacyl‐tRNA in the accommodation process

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Factor-free (“Non-enzymic”) and factor-dependent systems of translation of polyuridylic acid by Escherichia coli ribosomes

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Recognition of the Codon-Anticodon Helix by Ribosomal RNA

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Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

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Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors

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Hydrolysis of Guanosine 5'-Triphosphate Associated with Binding of Aminoacyl Transfer Ribonucleic Acid to Ribosomes

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Transient Conformational States of Aminoacyl-tRNA during Ribosome Binding Catalyzed by Elongation Factor Tu

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Mechanism of the Inhibition of Protein Synthesis by Kirromycin. Role of Elongation Factor Tu and Ribosomes

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Ribosome fidelity: tRNA discrimination, proofreading and induced fit

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The Involvement of Two Distinct Regions of 23 S Ribosomal RNA in tRNA Selection

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Conformational Change of Elongation Factor Tu (EF-Tu) Induced by Antibiotic Binding

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A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition

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Limitations of translational accuracy

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GTPase Mechanisms and Functions of Translation Factors on the Ribosome

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Fluorescence characterization of the interaction of various transfer RNA species with elongation factor Tu.cntdot.GTP: evidence for a new functional role for elongation factor Tu in protein biosynthesis

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Intact Aminoacyl-tRNA Is Required To Trigger GTP Hydrolysis by Elongation Factor Tu on the Ribosome

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Effect of Mg2+ concentration, polyamines, streptomycin, and mutations in ribosomal proteins on the accuracy of the two-step selection of aminoacyl-tRNAs in protein biosynthesis.

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Accuracy of protein biosynthesis. A kinetic study of the reaction of poly(U)-programmed ribosomes with a leucyl-tRNA2-elongation factor Tu-GTP complex.

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Mutations in 23 S Ribosomal RNA Perturb Transfer RNA Selection and can Lead to Streptomycin Dependence

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pH-dependent conformational flexibility within the ribosomal peptidyl transferase center.

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The 530 loop of 16S rRNA: a signal to EF-Tu?

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The structure and dynamics of ribosomal protein L12

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Macromolecular arrangement in the aminoacyl-tRNA.cntdot.elongation factor Tu.cntdot.GTP ternary complex. A fluorescence energy transfer study

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Elongation factor Tu can reduce translation errors in poly(U)-directed cell-free systems

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Characterisation of a new, fully active fluorescent derivative of E. coli tRNA Phe.

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Time-resolved fluorescence studies on the ternary complex formed between bacterial elongation factor Tu, guanosine 5'-triphosphate, and phenylalanyl-tRNAPhe

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Probing Gene Expression in Live Cells, One Protein Molecule at a Time

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The A-Z of bacterial translation inhibitors

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Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome

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Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

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Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype

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Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

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Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

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Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

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Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome

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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the <i>Escherichia coli</i> ribosome

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Sarecycline inhibits protein translation in<i>Cutibacterium acnes</i>70S ribosome using a two-site mechanism

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Single molecule FRET for the study on structural dynamics of biomolecules

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Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition

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High-Resolution Single-Molecule FRET via DNA eXchange (FRET X)Preprint

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Single-Molecule Multicolor FRET Assay for Studying Structural Dynamics of Biomolecules.

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Kinetics of the Triplex-Duplex Transition in DNA

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