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Cited by 64Lipid metabolism and disordersLipid metabolism and biosynthesisMuscle metabolism and nutrition

Gender Differences in Lipoprotein Lipase Activity after Acute Exercise

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Perreault, Leigh, Lavely, Jennifer M., Kittelson, John M., Horton, Tracy J.·2004·Obesity Research
DOI 10.1038/oby.2004.31
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Abstract

Objective: To determine whether gender differences exist in lipoprotein lipase (LPL) activity in response to exercise and/or insulin. Exercise and insulin are known modulators of LPL activity in men, but this is less clear in women. LPL activity may predict propensity for obesity; therefore, understanding its modulators is of considerable importance. Research Methods and Procedures: Gender differences in skeletal muscle and adipose tissue LPL activity were determined after a single bout of exercise followed by a hyperinsulinemic/euglycemic clamp and compared with an identical rest day in healthy lean men (n = 10) and women (n = 10). Muscle and adipose tissue biopsies were obtained pre‐ (post‐exercise vs. rest) and post‐clamp. Results: Basal levels of muscle and adipose tissue LPL activity were not different between men and women. There was, however, a significant gender by day interaction for muscle LPL activity (p = 0.023) and adipose tissue LPL activity (p = 0.013). In muscle, this was because of a significant increase in LPL activity on the exercise vs. rest day in men (p < 0.001) but not women. Adipose tissue LPL activity also increased significantly in men on the exercise day relative to rest day (p = 0.04) but decreased in women (p = 0.10). The hyperinulinemic/euglycemic clamp had no independent effect on tissue LPL activity, in either gender, after rest or exercise. Discussion: In the 3 to 4 hours after exercise, muscle and adipose tissue LPL activity increased significantly in men, whereas LPL activity remained unchanged in women.

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  • Women tend to favor utilization of exogenous carbohydrates, leading to an increase in carbohydrate oxidation.

    “Women tend to favor the utilization of exogenous carbohydrates, leading to an increase in carbohydrate oxidation (175, 188, 197).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [175]

    The Introduction (page not available) says that women tend to oxidize a greater proportion of lipid relative to carbohydrate than men during submaximal exercise—the opposite of the claimed tendency toward greater carbohydrate oxidation. The Whole-Body Substrate Oxidation section (page not available) found no gender difference in the relative contribution of carbohydrate and fat, and does not identify exogenous carbohydrate use. (LLM, conf=0.86)

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  • Athletic men initially have lower rates of fat oxidation but approach rates comparable to women as duration of moderate aerobic exercise increases.

    “It has been reported that athletic men initially have lower rates of fat oxidation, but approach rates comparable to women as duration of moderate aerobic exercise increases (175).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [175]

    The Introduction says women oxidize a greater proportion of lipid than men at a given submaximal exercise intensity. It does not say that men's fat oxidation approaches women's as exercise duration increases. The Whole-Body Substrate Oxidation section reports no sex difference after adjustment for fat-free mass, but does not describe the claimed progression during exercise; the Subjects section describes participants as habitually active rather than athletic. (LLM, conf=0.84)

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  • Research on oral glucose intake concurrent with exercise yields conflicting results on plasma glucose concentrations, with findings indicating lower or greater concentrations in women, or similar levels with men.

    “Research on oral glucose intake concurrent with exercise yields conflicting results on plasma glucose concentrations, with findings indicating lower (241) or greater (175) concentrations in women, or similar levels with men (188, 197).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [175]

    The Hyperinsulinemic/Euglycemic Clamp results (page not provided) report no difference in glucose concentrations between men and women before the clamp on the exercise day, supporting the similar-levels finding attributed to this paper. The Exercise Day and Resting Day methods show that glucose was infused during a post-exercise clamp, not taken orally during exercise. This paper therefore does not support the oral-intake condition; the lower and greater findings are attributed to other citations. (LLM, conf=0.87)

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Research works printed but not linked: 1

  1. by Readcube (Labtiva Inc.), Wiley Online Library on [04/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Authors
Perreault, L., Lavely, J. M., Kittelson, J. M., & Horton, T. J.
Affiliations
University of Colorado Health (US)
Corresponding author
Perreault, Leigh
ORCID
Perreault, Leigh
Venue
Obesity Research
Publisher
Wiley
Published
2004-02
Volume
12
Issue
2
Pages
241-249
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2004.31
OpenAlex
W2062285202
Cited by
64
References
37
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3140 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Endocrine Fellows Foundation
  • National Institutes of Health (5r01hl059331-04)
  • National Heart, Lung, and Blood Institute (HL59331, HL04226)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK48520, P30DK048520)
  • National Center for Research Resources (M01RR000051)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
lipoprotein lipase, gender differences, acute exercise, hyperinsulinemic-euglycemic clamp, skeletal muscle, adipose tissue, insulin, obesity risk
MeSH terms
Adipose Tissue, Adult, Female, Humans, Insulin, Lipoprotein Lipase, Male, Oxygen Consumption, Sex Characteristics, Glucose Clamp Technique, Exercise, Muscle, Skeletal

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