The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Role of Obesity‐associated Loci Identified in Genome‐wide Association Studies in the Determination of Pediatric BMI
Open accessAbstract
The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. A number of genetic determinants of adult BMI have already been established through genome‐wide association (GWA) studies. In this study, we examined 25 single‐nucleotide polymorphisms (SNPs) corresponding to 13 previously reported genomic loci in 6,078 children with measures of BMI. Fifteen of these SNPs yielded at least nominally significant association to BMI, representing nine different loci including INSIG2, FTO, MC4R, TMEM18, GNPDA2, NEGR1, BDNF, KCTD15, and 1q25. Other loci revealed no evidence for association, namely at MTCH2, SH2B1, 12q13, and 3q27. For the 15 associated variants, the genotype score explained 1.12% of the total variation for BMI z‐score. We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort.
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Scuteri, A., Sanna, S., Chen, W.-M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030115 · Cited by 1,724
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.140 · Cited by 1,325
Self-citationA common genetic variant is associated with adult and childhood obesity.
Herbert, A., Gerry, N. P., McQueen, M. B., Heid, I. M., Pfeufer, A., Illig, T., Wichmann, H.-E., Meitinger, T., Hunter, D., Hu, F. B., et al. (2006) · Science · doi:10.1126/science.1124779 · Cited by 732 · cited 1×
“Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity (1) but replication attempts have yielded inconsistent outcomes (2–6).”
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Hakonarson, H., Grant, S. F. A., Bradfield, J. P., Marchand, L., Kim, C. E., Glessner, J. T., Grabs, R., Casalunovo, T., Taback, S. P., Frackelton, E. C., et al. (2007) · Nature · doi:10.1038/nature06010 · Cited by 542
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Cited by
A genome-wide association meta-analysis identifies new childhood obesity loci
the Early Growth Genetics (EGG) Consortium (2012) · Nature Genetics · doi:10.1038/ng.2247 · Cited by 428
Neurotrophic factor control of satiety and body weight
Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203
Lee, A. W. S., Hengstler, H., Schwald, K., Berriel-Diaz, M., Loreth, D., Kirsch, M., Kretz, O., Haas, C. A., de Angelis, M. H., Herzig, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041537 · Cited by 84
Influence of BDNF genetic polymorphisms in the pathophysiology of aging-related diseases
Urbina-Varela, R., Soto-Espinoza, M. I., Vargas, R., Quiñones, L., & del Campo, A. (2020) · Aging and disease · doi:10.14336/ad.2020.0310 · Cited by 27
Metadata
- Authors
- Zhao, J., Bradfield, J. P., Li, M., Wang, K., Zhang, H., Kim, C. E., Annaiah, K., Glessner, J. T., Thomas, K., Garris, M., Frackelton, E. C., Otieno, F. G., Shaner, J. L., Smith, R. M., Chiavacci, R. M., Berkowitz, R. I., Hakonarson, H., & Grant, S. F. A.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-12
- Volume
- 17
- Issue
- 12
- Pages
- 2254-2257
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2083539491
- Cited by
- 189
- References
- 5
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, J., Bradfield, J. P., Li, M., Wang, K., Zhang, H., Kim, C. E., Annaiah, K., Glessner, J. T., Thomas, K., Garris, M., Frackelton, E. C., Otieno, F. G., Shaner, J. L., Smith, R. M., Chiavacci, R. M., Berkowitz, R. I., Hakonarson, H., & Grant, S. F. A. (2009). The Role of Obesity‐associated Loci Identified in Genome‐wide Association Studies in the Determination of Pediatric BMI. Obesity. https://doi.org/10.1038/oby.2009.159
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