Neurotrophic factor control of satiety and body weight
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Energy balance--that is, the relationship between energy intake and energy expenditure--is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin is an adipocyte-derived cytokine that suppresses appetite and increases energy expenditure. Ironically, obese individuals have high levels of plasma leptin and are resistant to leptin treatment. Neurotrophic factors, particularly ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF), are also important for the control of body weight. CNTF can overcome leptin resistance in order to reduce body weight, although CNTF and leptin activate similar signalling cascades. Mutations in the gene encoding BDNF lead to insatiable appetite and severe obesity.
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BDNF possesses central anorexigenic effects and promotes increased energy expenditure by increasing sympathetic outflow.
“Third, exercise-induced irisin may promote brain-derived neurotrophic factor (BDNF) synthesis in the CNS [7,67,68]; BDNF is a peptide known to possess central anorexigenic effects and to promote increased energy expenditure by increasing sympathetic outflow [246] (3).”
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Research works printed but not linked: 2
- [85]Wang C Bomberg E Billington CJ Levine AS Kotz CM Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure Brain Res 1336 66 77 2010 20398635 PMC4452019
- [96]Spaeth AM Kanoski SE Hayes MR Grill HJ TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin American journal of physiology. Endocrinology and metabolism 302 E1252 60 2012 22374757 PMC3361983
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The genetics of obesity: From discovery to biology
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- Authors
- Xu, B., & Xie, X.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Xu, Baoji
- Venue
- Nature reviews. Neuroscience
- Published
- 2016-04-07
- Volume
- 17
- Issue
- 5
- Pages
- 282-292
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4898883
- OpenAlex
- W2324202603
- Cited by
- 203
- References
- 161
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 14 · 2023: 37 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 6
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103335, DK103335)
- National Institute of Neurological Disorders and Stroke (NS095425, NS073930, R21NS095425, R01NS073930)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- neurotrophic factors, brain-derived neurotrophic factor, ciliary neurotrophic factor, satiety, body weight regulation, energy balance, leptin, leptin resistance, obesity, appetite, energy expenditure
- MeSH terms
- Animals, Body Weight, Brain, Energy Metabolism, Humans, Obesity, Satiety Response, Signal Transduction, Brain-Derived Neurotrophic Factor, Ciliary Neurotrophic Factor
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