A common genetic variant is associated with adult and childhood obesity.
Abstract
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
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To limit multiple testing, a more stringent criterion for SNP selection was used in the second sample, genotyping only the three SNPs found significant in both SVO and Dictator in the first sample (rs2268490, rs237887, rs1042778).
“To limit the conundrum of multiple testing, we used a more stringent criteria for SNP selection in the second sample[39]. Subjects were genotyped solely for the three SNPs found to be significant in both the SVO and Dictator in the first sample (rs2268490, rs237887 and rs1042778).”
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Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057 · see citing works
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670 · see citing works
Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993) · PubMed · Cited by 3,679 · see citing works
Body Weight and Mortality among Women
Manson, J. E., Willett, W. C., Stampfer, M. J., Colditz, G. A., Hunter, D. J., Hankinson, S. E., Hennekens, C. H., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509143331101 · Cited by 2,005 · see citing works
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900 · see citing works
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674 · see citing works
On the allelic spectrum of human disease
Reich, D. E., & Lander, E. S. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02410-6 · Cited by 1,185 · see citing works
Implementing a unified approach to family-based tests of association
Laird, N. M., Horvath, S., & Xu, X. P. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(2000)19:1+ · Cited by 854 · see citing works
Horvath, S., Xu, X. P., & Laird, N. M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200625 · Cited by 739 · see citing works
Bell, C. G., Walley, A. J., & Froguel, P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1556 · Cited by 650 · see citing works
Yabe, D., Brown, M. S., & Goldstein, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162488899 · Cited by 557 · see citing works
Modern science versus the stigma of obesity
Friedman, J. M. (2004) · Nature Medicine · doi:10.1038/nm0604-563 · Cited by 368 · see citing works
Schousboe, K., Willemsen, G. A. H. M., Kyvik, K. O., Mortensen, J., Boomsma, D. I., Cornes, B. K., Davis, C. J., Fagnani, C., Hjelmborg, J., Kaprio, J. A., et al. (2003) · Twin Research · doi:10.1375/136905203770326411 · Cited by 326 · see citing works
PBAT: tools for family-based association studies.
Lange, C., DeMeo, D., Silverman, E. K., Weiss, S. T., & Laird, N. M. (2004) · The American Journal of Human Genetics · doi:10.1086/381563 · Cited by 268 · see citing works
Hinney, A., Hohmann, S., Geller, F., VOGEL, C., Hess, C., Wermter, A., Brokamp, B., Goldschmidt, H., Siegfried, W., Remschmidt, H., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030233 · Cited by 207 · see citing works
A multivariate family-based association test using generalized estimating equations: FBAT-GEE
Lange, C. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.195 · Cited by 198 · see citing works
Genomic screening and replication using the same data set in family-based association testing
Steen, K. V., McQueen, M. B., Herbert, A. G., Raby, B. A., Lyon, H. N., DeMeo, D. L., Murphy, A., Lasky-Su, J. A., Datta, S., Rosenow, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1582 · Cited by 172 · see citing works
Self-citationGenomewide Linkage Analysis of Body Mass Index across 28 Years of the Framingham Heart Study
Atwood, L. D., Heard‐Costa, N. L., Cupples, L. A., Jaquish, C. E., Wilson, P. W. F., & D’Agostino, R. B. (2002) · The American Journal of Human Genetics · doi:10.1086/343822 · Cited by 158 · see citing works
A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes
Deng, H., Deng, H., Liu, Y.-J., Liu, Y.-Z., Xu, F.-H., Shen, H., Conway, T., Li, J., Huang, Q.-Y., Davies, K. M., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339934 · Cited by 156 · see citing works
The Framingham Study : ITS 50-Year Legacy and Future Promise
Kannel, W. B. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.6.60 · Cited by 148 · see citing works
Lange, C., DeMeo, D. L., & Laird, N. M. (2002) · The American Journal of Human Genetics · doi:10.1086/344696 · Cited by 145 · see citing works
Genetics of common forms of obesity: a brief overview
Lyon, H. N., & Hirschhorn, J. N. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.215s · Cited by 132 · see citing works
Heid, I. M., Vollmert, C., Hinney, A., Döring, A., Geller, F., Löwel, H., Wichmann, H. ‐., Illig, T., Hebebrand, J., & Kronenberg, F. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.027011 · Cited by 114 · see citing works
Takaishi, K., Duplomb, L., Wang, M.-Y., Li, J., & Unger, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401715101 · Cited by 110 · see citing works
Genetic Variation at the Adiponectin Locus and Risk of Type 2 Diabetes in Women
Hu, F. B., Doria, A., Li, T., Meigs, J. B., Liu, S., Memişoğlu, A., Hunter, D., & Manson, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.1.209 · Cited by 102 · see citing works
New advances in the genetics of early onset obesity
Farooqi, I. S., & O’Rahilly, S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803056 · Cited by 89 · see citing works
Cheverud, J. M., Ehrich, T. H., Hrbek, T., Kenney‐Hunt, J. P., Pletscher, L. S., & Semenkovich, C. F. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3328 · Cited by 83 · see citing works
Using the Noninformative Families in Family-Based Association Tests: A Powerful New Testing Strategy
Lange, C., DeMeo, D. L., Silverman, E. K., Weiss, S. T., & Laird, N. M. (2003) · The American Journal of Human Genetics · doi:10.1086/378591 · Cited by 82 · see citing works
Perspectives: molecular genetic research in human obesity
Hebebrand, J., Friedel, S., Schäuble, N., Geller, F., & Hinney, A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00106.x · Cited by 80 · see citing works
HSD17B1 Gene Polymorphisms and Risk of Endometrial and Breast Cancer
Setiawan, V. W., Hankinson, S. E., Colditz, G. A., Hunter, D. J., & Vivo, I. D. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-03-0241 · Cited by 68 · see citing works
Lange, C., Lyon, H. N., DeMeo, D. L., Raby, B. A., Silverman, E. K., & Weiss, S. T. (2003) · Human Heredity · doi:10.1159/000073728 · Cited by 54 · see citing works
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Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
Meta-analysis in clinical trials revisited
DerSimonian, R., & Laird, N. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.09.002 · Cited by 2,677 · see citing works
the GIANT Consortium (2009) · Nature Genetics · doi:10.1038/ng.287 · Cited by 1,720 · see citing works
Replicating genotype–phenotype associations
NCI-NHGRI Working Group on Replication in Association Studies, Chanock, S. J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D. J., Thomas, G., Hirschhorn, J. N., Abecasis, G., Altshuler, D., et al. (2007) · Nature · doi:10.1038/447655a · Cited by 1,352 · see citing works
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213 · see citing works
Mapping the Genetic Architecture of Gene Expression in Human Liver
Schadt, E. E., Molony, C. M., Chudin, E., Hao, K., Yang, X., Lum, P. Y., Kasarskis, A., Zhang, B., Wang, S. S.-M., Suver, C., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060107 · Cited by 909 · see citing works
Greene, W. H., & Hensher, D. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511845062 · Cited by 771 · see citing works
Assessment of cumulative evidence on genetic associations: interim guidelines
Ioannidis, J. P. A., Boffetta, P., Little, J., O'Brien, T. R., Uitterlinden, A. G., Vineis, P., Balding, D. J., Chokkalingam, A. P., Dolan, S. M., Flanders, W. D., et al. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym159 · Cited by 549 · see citing works
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Plenge, R. M., Cotsapas, C. J., Davies, L. R. L., Price, A. L., de Bakker, P. I. W., Maller, J., Pe’er, I., Burtt, N. P., Blumenstiel, B. S., DeFelice, M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.27 · Cited by 550 · see citing works
August, G. P., Caprio, S., Fennoy, I., Freemark, M., KAUFMAN, F. R., Lustig, R. H., Silverstein, J. H., Speiser, P., Styne, D. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2458 · Cited by 518 · see citing works
Hinney, A., Nguyen, T. T., Scherag, A., Friedel, S., Brönner, G., Müller, T. D., Grallert, H., Illig, T., Wichmann, H. ‐., Rief, W., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001361 · Cited by 510 · see citing works
Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, S. S., Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, A., Borch-Johnsen, K., Rasmussen, S. S., et al. (2008) · Diabetes · doi:10.2337/db07-0910 · Cited by 476 · see citing works
The genetic contribution to non-syndromic human obesity
Walley, A. J., Asher, J. E., & Froguel, P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2594 · Cited by 402 · see citing works
Lasky-Su, J. A., Neale, B. M., Franke, B., Anney, R., Zhou, K., Maller, J., Vásquez, A. A., Chen, W., Asherson, P. J., Buitelaar, J. K., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30867 · Cited by 388 · see citing works
Highly parallel genomic assays
Fan, J., Chee, M. S., & Gunderson, K. L. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1901 · Cited by 384 · see citing works
Overcoming the Winner’s Curse: Estimating Penetrance Parameters from Case-Control Data
Zöllner, S. K., & Pritchard, J. K. (2007) · The American Journal of Human Genetics · doi:10.1086/512821 · Cited by 382 · see citing works
Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma
Tantisira, K. G., Lasky-Su, J. A., Harada, M., Murphy, A., Litonjua, A. A., Himes, B. E., Lange, C., Lazarus, R. M., Sylvia, J. S., Klanderman, B. J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0911353 · Cited by 368 · see citing works
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Kathiresan, S., Manning, A. K., Demissie, S., D’Agostino, R. B., Surti, A., Guiducci, C., Gianniny, L., Burtt, N. P., Melander, O., Orho‐Melander, M., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s17 · Cited by 341 · see citing works
Speakman, J. R., Rance, K. A., & Johnstone, A. M. (2008) · Obesity · doi:10.1038/oby.2008.318 · Cited by 325 · see citing works
Regulation ofFto/Ftmgene expression in mice and humans
Stratigopoulos, G., Padilla, S. L., LeDuc, C. A., Watson, E., Hattersley, A. T., McCarthy, M. I., Zeltser, L. M., Chung, W. K., & Leibel, R. L. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00839.2007 · Cited by 323 · see citing works
Evolution in Health and Disease
(2007) · doi:10.1093/acprof:oso/9780199207466.001.0001 · Cited by 322 · see citing works
Genetic Epidemiology of Obesity
Yang, W., Kelly, T. N., & He, J. (2007) · Epidemiologic Reviews · doi:10.1093/epirev/mxm004 · Cited by 308 · see citing works
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
Yang, X., Deignan, J. L., Qi, H., Zhu, J., Qian, S., Zhong, J., Torosyan, G., Majid, S., Falkard, B., Kleinhanz, R. R., et al. (2009) · Nature Genetics · doi:10.1038/ng.325 · Cited by 288 · see citing works
Genome-wide association studies of obesity and metabolic syndrome
Fall, T., & Ingelsson, E. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.08.018 · Cited by 295 · see citing works
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., Bachner-Melman, R., Maril, A., Bornstein, G., Knafo, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005535 · Cited by 278 · see citing works
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia
Lencz, T., Morgan, T., Athanasiou, M., Dain, B., Reed, C. R., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001983 · Cited by 278 · see citing works
Gene-environment interaction and obesity
Qi, L., & Cho, Y. A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00128.x · Cited by 276 · see citing works
Bessesen, D. H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0520 · Cited by 255 · see citing works
Model of genetic variation in human social networks
Fowler, J. H., Dawes, C. T., & Christakis, N. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806746106 · Cited by 245 · see citing works
From monogenic to polygenic obesity: recent advances
Hinney, A., Vogel, C. I. G., & Hebebrand, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0096-6 · Cited by 247 · see citing works
Non-Replication and Inconsistency in the Genome-Wide Association Setting
Ioannidis, J. P. A. (2007) · Human Heredity · doi:10.1159/000103512 · Cited by 245 · see citing works
Variations in the FTO gene are associated with severe obesity in the Japanese
Hotta, K., Nakata, Y., Matsuo, T., Kamohara, S., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Masuzaki, H., et al. (2008) · Journal of Human Genetics · doi:10.1007/s10038-008-0283-1 · Cited by 241 · see citing works
Response inhibition and ADHD traits: Correlates and heritability in a community sample
Crosbie, J., Arnold, P., Paterson, A., Swanson, J., Dupuis, A., Li, X., Shan, J., Goodale, T., Tam, C., Strug, L. J., et al. (2013) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-012-9693-9 · Cited by 218 · see citing works
Albuquerque, D., Stice, E. M., Rodríguez‐López, R., Manco, L., & Nóbrega, C. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1015-9 · Cited by 223 · see citing works
Fat synthesis and adiposity regulation in Caenorhabditis elegans
Watts, J. L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.11.002 · Cited by 222 · see citing works
Medical Sequencing at the Extremes of Human Body Mass
Ahituv, N., Kavaslar, N., Schackwitz, W., Ustaszewska, A., Martin, J., Hébert, S., Doelle, H., Ersoy, B. A., Kryukov, G. V., Schmidt, S., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/513471 · Cited by 221 · see citing works
Chang, Y., Liu, P., Lee, W., Chang, T., Jiang, Y., Li, H., Kuo, S., Lee, K.-C., & Chuang, L. (2008) · Diabetes · doi:10.2337/db08-0377 · Cited by 220 · see citing works
Cupples, L. A., Arruda, H. T., Benjamin, E. J., D’Agostino, R. B., Demissie, S., DeStefano, A. L., Dupuis, J., Falls, K. M., Fox, C. S., Gottlieb, D. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s1 · Cited by 212 · see citing works
The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy
Manolio, T. A., & Collins, F. S. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.061907.093117 · Cited by 208 · see citing works
Grant, S. F. A., Li, M., Bradfield, J. P., Kim, C., Annaiah, K., Santa, E., Glessner, J., Casalunovo, T., Frackelton, E. C., Otieno, F. G., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001746 · Cited by 199 · see citing works
Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease
Arnett, D. K., Baird, A. E., Barkley, R. A., Basson, C. T., Boerwinkle, E., Ganesh, S. K., Herrington, D. M., Hong, Y., Jaquish, C. E., McDermott, D. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.183679 · Cited by 200 · see citing works
Implicit Theories of Body Weight: Entity Beliefs Can Weigh You Down
Burnette, J. L. (2010) · Personality and Social Psychology Bulletin · doi:10.1177/0146167209359768 · Cited by 193 · see citing works
Moving toward a system genetics view of disease
Sieberts, S. K., & Schadt, E. E. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9040-6 · Cited by 193 · see citing works
Zhao, J., Bradfield, J. P., Li, M., Wang, K., Zhang, H., Kim, C., Annaiah, K., Glessner, J., Thomas, K., Garris, M., et al. (2009) · Obesity · doi:10.1038/oby.2009.159 · Cited by 189 · see citing works
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
Liu, Y., Liu, X.-G., Wang, L., Christian Dina, C., Yan, H., Liu, J., Levy, S., Papasian, C. J., Drees, B. M., Hamilton, J. J., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn072 · Cited by 185 · see citing works
Genetic factors in human obesity
Farooqi, I. S., & O’Rahilly, S. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00315.x · Cited by 186 · see citing works
Xia, Q., & Grant, S. F. A. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12020 · Cited by 182 · see citing works
The pursuit of genome-wide association studies: where are we now?
Ku, C., Loy, E. Y., Yudi Pawitan, Y., & Chia, K. S. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.19 · Cited by 181 · see citing works
Statistical false positive or true disease pathway?
Todd, J. A. (2006) · Nature Genetics · doi:10.1038/ng0706-731 · Cited by 178 · see citing works
Genome wide association study identifies KCNMA1contributing to human obesity
Jiao, H., Arner, P., Hoffstedt, J., Brodin, D., Dubern, B., Czernichow, S., Hooft, F. M. V., Axelsson, T., Pedersen, O. B., Hansen, T. F., et al. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-51 · Cited by 180 · see citing works
Evolutionary origins of obesity
Bellisari, A. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00392.x · Cited by 175 · see citing works
Fox, C. S., Heard‐Costa, N. L., Cupples, L. A., Dupuis, J., Vasan, R. S., & Atwood, L. D. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s18 · Cited by 171 · see citing works
Unraveling the Genetics of Human Obesity
Mutch, D. M., & Clément, K. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020188 · Cited by 169 · see citing works
Prediction of individual genetic risk of complex disease
Wray, N. R., Goddard, M. E., & Visscher, P. M. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.006 · Cited by 165 · see citing works
Applications of Linkage Disequilibrium and Association Mapping in Crop Plants
Ersoz, E. S., Yu, J., & Buckler, E. S. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6295-7_5 · Cited by 165 · see citing works
Biostatistical Aspects of Genome‐Wide Association Studies
Ziegler, A., König, I. R., & Thompson, J. R. (2008) · Biometrical Journal · doi:10.1002/bimj.200710398 · Cited by 159 · see citing works
Association of the FTO Gene With BMI
Hunt, S. C., Stone, S., Xin, Y., Scherer, C., Magness, C. L., Iadonato, S. P., Hopkins, P. N., & Adams, T. D. (2008) · Obesity · doi:10.1038/oby.2007.126 · Cited by 156 · see citing works
Lyon, H. N., Emilsson, V., Hinney, A., Heid, I. M., Lasky-Su, J. A., Zhu, X., Þorleifsson, G., Gunnarsdottir, S., Walters, G. B., Þorsteinsdóttir, U., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030061 · Cited by 153 · see citing works
The Genetic Basis of Type 2 Diabetes.
Das, S. K., & Elbein, S. C. (2006) · PubMed · doi:10.1901/jaba.2006.2-100 · Cited by 153 · see citing works
Environmental and Genetic Risk Factors in Obesity
Hebebrand, J., & Hinney, A. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.07.006 · Cited by 150 · see citing works
Meta‐Analysis of Genome‐wide Linkage Studies in BMI and Obesity
Saunders, C. L., Chiodini, B., Sham, P. C., Lewis, C. M., Abkevich, V., Adeyemo, A., de Andrade, M., Arya, R., Berenson, G. S., Blangero, J., et al. (2007) · Obesity · doi:10.1038/oby.2007.269 · Cited by 151 · see citing works
Precision Health: The Role of the Social and Behavioral Sciences in Advancing the Vision
Hekler, E. B., Tiro, J. A., Hunter, C. M., & Nebeker, C. (2020) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa018 · Cited by 147 · see citing works
Development and Evaluation of a Genetic Risk Score for Obesity
Belsky, D. W., Moffitt, T. E., Sugden, K., Williams, B., Houts, R., McCarthy, J., & Caspi, A. (2013) · Biodemography and Social Biology · doi:10.1080/19485565.2013.774628 · Cited by 165 · see citing works
Array-Based DNA Diagnostics: Let the Revolution Begin
Beaudet, A. L., & Belmont, J. W. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.59.012907.101800 · Cited by 144 · see citing works
Trikalinos, T. A., Salanti, G., Zintzaras, E., & Ioannidis, J. P. A. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00413-0 · Cited by 141 · see citing works
Genetic dissection of type 2 diabetes
Ridderstråle, M., & Groop, L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.002 · Cited by 140 · see citing works
Recent progress in the genetics of common obesity
Loos, R. J. F. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03523.x · Cited by 139 · see citing works
O’Donnell, C. J., Cupples, L. A., D’Agostino, R. B., Fox, C. S., Hoffmann, U., Hwang, S., Ingellson, E., Liu, C., Murabito, J. M., Polak, J. F., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s4 · Cited by 138 · see citing works
Hotta, K., Nakamura, M., Nakamura, T., Matsuo, T., Nakata, Y., Kamohara, S., Miyatake, N., Kotani, K., Komatsu, R., Itoh, N., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.106 · Cited by 135 · see citing works
Jarick, I., Vogel, C. I. G., Scherag, S., Schäfer, H., Hebebrand, J., Hinney, A., & Scherag, A. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq518 · Cited by 136 · see citing works
Analyses of shared genetic factors between asthma and obesity in children
Melén, E., Himes, B. E., Brehm, J. M., Boutaoui, N., Klanderman, B. J., Sylvia, J. S., & Lasky-Su, J. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.030 · Cited by 134 · see citing works
On the Replication of Genetic Associations: Timing Can Be Everything!
Lasky-Su, J. A., Lyon, H. N., Emilsson, V., Heid, I. M., Molony, C. M., Raby, B. A., Lazarus, R. M., Klanderman, B. J., Soto-Quirós, M. E., Ávila, L., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.018 · Cited by 132 · see citing works
Shen, G.-Q., Rao, S., Martinelli, N., Li, L., Olivieri, O., Corrocher, R., Abdullah, K. G., Hazen, S. L., Smith, J. D., Barnard, J., et al. (2007) · Journal of Human Genetics · doi:10.1007/s10038-007-0230-6 · Cited by 131 · see citing works
ARG1 Is a Novel Bronchodilator Response Gene
Litonjua, A. A., Lasky-Su, J. A., Schneiter, K., Tantisira, K. G., Lazarus, R. M., Klanderman, B. J., Lima, J. J., Irvin, C. G., Peters, S. P., Hanrahan, J. P., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200709-1363oc · Cited by 130 · see citing works
Appetitive traits and child obesity: measurement, origins and implications for intervention
Carnell, S., & Wardle, J. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108008641 · Cited by 124 · see citing works
Genome-wide association with select biomarker traits in the Framingham Heart Study
Benjamin, E. J., Dupuis, J., Larson, M. G., Lunetta, K. L., Booth, S. L., Govindaraju, D. R., Kathiresan, S., Keaney, J. F., Keyes, M. J., Lin, J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s11 · Cited by 125 · see citing works
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Christian Dina, C., Meyre, D., Samson, C., Tichet, J., Marre, M., Jouret, B., Charles, M.-A. A., Balkau, B., & Froguel, P. (2007) · Science · doi:10.1126/science.1129402 · Cited by 125 · see citing works
Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
McCaffery, J. M., Papandonatos, G. D., Peter, I., Huggins, G. S., Raynor, H. A., Delahanty, L. M., Cheskin, L. J., Balasubramanyam, A., Wagenknecht, L. E., & Wing, R. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.026955 · Cited by 124 · see citing works
Linkage Disequilibrium in Wild Mice
Laurie, C. C., Nickerson, D. A., Anderson, A. D., Weir, B. S., Livingston, R. J., Dean, M. D., Smith, K. L., Schadt, E. E., & Nachman, M. W. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030144 · Cited by 123 · see citing works
Obesity – A neuropsychological disease? Systematic review and neuropsychological model
Jauch‐Chara, K., & Oltmanns, K. M. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.001 · Cited by 121 · see citing works
Insulin-induced gene: A new regulator in lipid metabolism
Dong, X., & Tang, S.-Q. (2010) · Peptides · doi:10.1016/j.peptides.2010.07.020 · Cited by 122 · see citing works
Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway
Do, R., Kiss, R., Gaudet, D., & Engert, J. C. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01099.x · Cited by 118 · see citing works
León‐Mimila, P., Villamil‐Ramírez, H., Villalobos‐Comparán, M., Villarreal-Molina, M. T., Romero‐Hidalgo, S., López-Contreras, B. E., Gutiérrez‐Vidal, R., Vega‐Badillo, J., Jacobo‐Albavera, L., Posadas‐Romero, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070640 · Cited by 119 · see citing works
Genetic Determinants of Childhood Obesity
Littleton, S. H., Berkowitz, R. I., & Grant, S. F. A. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00496-1 · Cited by 119 · see citing works
Khoury, M. J., Little, J., GWINN, M. L., & Ioannidis, J. P. A. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl253 · Cited by 118 · see citing works
Integrating Genetics and Social Science: Genetic Risk Scores
Belsky, D. W., & Israel, S. (2014) · Biodemography and Social Biology · doi:10.1080/19485565.2014.946591 · Cited by 114 · see citing works
Genetics of fat tissue accumulation in pigs: a comparative approach
Switonski, M., Stachowiak, M., Cieślak, J., Bartz, M., & Grzes, M. (2010) · Journal of Applied Genetics · doi:10.1007/bf03195724 · Cited by 116 · see citing works
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Loos, R. J. F., Barroso, I., O’Rahilly, S., & Wareham, N. J. (2007) · Science · doi:10.1126/science.1130012 · Cited by 115 · see citing works
Evaluation of coverage variation of SNP chips for genome-wide association studies
Li, M., Li, C., & Guan, W. (2008) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5202007 · Cited by 113 · see citing works
Xi, B., Shen, Y., Zhang, M., Liu, X., Zhao, X., Wu, L., Cheng, H., Hou, D., Lindpaintner, K., Liu, L., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-107 · Cited by 112 · see citing works
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Rosskopf, D., Bornhorst, A., Rimmbach, C., Schwahn, C., Kayser, A., Krüger, A., Tessmann, G., Geissler, I., Kroemer, H. K., & Völzke, H. (2007) · Science · doi:10.1126/science.1130571 · Cited by 112 · see citing works
Molecular genetic studies of gene identification for sarcopenia
Tan, L., Liu, S., Lei, S., Papasian, C. J., & Deng, H. (2011) · Human Genetics · doi:10.1007/s00439-011-1040-7 · Cited by 111 · see citing works
The success of the genome-wide association approach: a brief story of a long struggle
Seng, K. C., & Seng, C. K. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.12 · Cited by 109 · see citing works
Gene–environment interactions and obesity—Further aspects of genomewide association studies
Andreasen, C. H., & Andersen, G. (2009) · Nutrition · doi:10.1016/j.nut.2009.06.001 · Cited by 105 · see citing works
Franks, P. W., Jablonski, K. A., Delahanty, L. M., McAteer, J. B., Kahn, S. E., Knowler, W. C., & Florez, J. C. (2008) · Diabetologia · doi:10.1007/s00125-008-1158-x · Cited by 106 · see citing works
A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases
Glessner, J., Bradfield, J. P., Wang, K., Takahashi, N., Zhang, H., Abou‐Sleiman, P. M., Mentch, F. D., Kim, C., Hou, C., Thomas, K., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.09.014 · Cited by 106 · see citing works
FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome
Ewens, K. G., Jones, M. R., Ankener, W., Stewart, D. R., Urbanek, M., Dunaif, A. E., Legro, R. S., Chua, A. K., Azziz, R., Spielman, R. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016390 · Cited by 106 · see citing works
Munawar, N., Ahsan, K., Muhammad, K., Ahmad, A., Anwar, M. A., Shah, I., Ameri, A. A., & Mughairbi, F. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147671 · Cited by 105 · see citing works
- Authors
- Herbert, A., Gerry, N. P., McQueen, M. B., Heid, I. M., Pfeufer, A., Illig, T., Wichmann, H.-E., Meitinger, T., Hunter, D., Hu, F. B., Colditz, G., Hinney, A., Hebebrand, J., Koberwitz, K., Zhu, X., Cooper, R., Ardlie, K., Lyon, H., Hirschhorn, J. N., Laird, N. M., Lenburg, M. E., Lange, C., & Christman, M. F.
- Affiliations
- Boston University (US)
- Corresponding author
- Herbert, Alan
- Christman, Michael F.
- ORCID
- Venue
- Science
- Published
- 2006-04-14
- Volume
- 312
- Issue
- 5771
- Pages
- 279-283
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2149512324
- Cited by
- 732
- References
- 32
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 2 · 2017: 17 · 2016: 19 · 2015: 28 · 2014: 30 · 2013: 37 · 2012: 39
- FWCI
- 75.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL54485, U01HL065899, R01HL066289, R01HL66289, R01HL074166, U01 HL65899)
- National Institute of Mental Health (R01MH59532, R01MH059532)
- National Cancer Institute (CA-87969, P01CA087969)
- National Institute of General Medical Sciences (R01GM046877)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200, K23DK067288, P30 DK-46200)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD060726)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- obesity, genetic association, INSIG2, childhood obesity, adult obesity, type 2 diabetes risk, whole genome scan, Framingham Heart Study, African Americans
- MeSH terms
- Adult, Alleles, Black or African American, Child, Europe, Female, Gene Frequency, Genes, Recessive, Genotype, Haplotypes, Humans, Male, Membrane Proteins, Models, Genetic, Obesity, Genetic Variation, Cohort Studies, Linkage Disequilibrium, Body Mass Index, Case-Control Studies, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, White People, Intracellular Signaling Peptides and Proteins
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