Excess Weight and the Risk of Incident Coronary Heart Disease Among Men and Women
Open accessAbstract
Overweight and obesity have been prospectively associated with the risk of coronary heart disease (CHD). Less clear is the relation of excess weight to risk of CHD among men and women with comorbid conditions, and the proportion of CHD risk attributable to excess weight in the US population. To assess the risk of CHD associated with excess weight among men and women with and without associated comorbid conditions, and determine the population attributable risk of CHD associated with excess weight. The study population consisted of two prospective cohorts, the Health Professionals Follow‐up Study (HPFS) (N = 42,351 men; age range at baseline, 39–75 years) and the Nurses' Health Study (NHS) (N = 76,703 women; age range at baseline, 39–65 years). A total of 2,771 incident cases of CHD among the men and 2,359 among the women were documented over the 16 years of follow‐up. Overall, the relative risk (RR) of CHD associated with BMI ≥30 kg/m 2 compared with BMI 18.5–22.9 kg/m 2 was 2.13 (95% confidence interval (CI), 1.82–2.48) among the men and 2.48 (95% CI, 2.20–2.80) among the women. The risk of CHD increased with BMI, both with and without the presence of comorbid conditions. Our estimates suggest that more than a third of all incident CHD in US men and women may be attributed to excess weight. Excess weight is associated with increased risk of CHD among men and women, both alone and in combination with comorbid conditions, though the results require careful interpretation. A substantial proportion of incident CHD may be attributed to excess weight.
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In these cohorts, body measurements and weight change are strong predictors of disease outcomes.
“Anthropometric measurements and weight changes strongly predict disease outcomes in these cohorts.20–26”
From Changes in diet and lifestyle and long-term weight gain in women and men (2011) · cites this paper as [26]
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Changes in diet and lifestyle and long-term weight gain in women and men
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- Authors
- Flint, A. J., Hu, F. B., Glynn, R. J., Caspard, H., Manson, J. E., Willett, W. C., & Rimm, E. B.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Sanofi (United States) (US)
- Corresponding author
- Flint, Alan J.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 18
- Issue
- 2
- Pages
- 377-383
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC2940230
- OpenAlex
- W1987483154
- Cited by
- 134
- References
- 37
- Citations by year
- 2025: 20 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 8 · 2012: 12
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464, R01HL034594)
- National Cancer Institute (U19CA055075, CA-55075, P01CA055075)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- overweight, coronary artery disease, body mass index, sex differences, comorbidities, population attributable risk, incident cardiovascular disease, Health Professionals Follow-up Study, Nurses' Health Study
- MeSH terms
- Adult, Aged, Coronary Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Severity of Illness Index, Sex Factors, Time Factors, Comorbidity, Body Mass Index, Incidence, Likelihood Functions, Proportional Hazards Models, Risk Assessment, Overweight
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