Overexpression of Constitutively Active PKG‐I Protects Female, But Not Male Mice From Diet‐Induced Obesity
Open accessAbstract
Cyclic guanosine monophosphate (cGMP)–dependent protein kinase I (PKG‐I) is a multifunctional protein. The direct effects of PKG‐I activation on energy homeostasis and obesity development are not well understood. Herein, we generated transgenic mice with expression of the constitutively active PKG‐I in adipose tissue as well as in other tissues. Male and female PKG‐I overexpressing mice were fed a low‐fat (LF) or high‐fat (HF) diet for 16 weeks. HF‐fed female PKG‐I transgenic mice had decreased body weight gain, lower percentage of body fat, and improved glucose tolerance compared to HF‐fed wild‐type (WT) controls. In contrast, male transgenic PKG‐I mice were not resistant to the development of HF‐diet‐induced obesity, and exhibited similar levels of adiposity and glucose intolerance as HF‐fed WT controls. Furthermore, we found that HF‐fed female transgenic PKG‐I mice had increased energy expenditure and cold‐induced adaptive thermogenesis compared to HF‐fed WT controls, which was associated with increased expression of uncoupling protein‐1 (UCP1) in brown adipose tissue (BAT). In addition, the rates of lipolysis in white adipose tissue (WAT) were also increased in female transgenic PKG‐I mice compared to WT controls due to increased phosphorylation of hormone‐sensitive lipase (HSL). However, in male mice, adaptive thermogenesis or WAT lipolysis was similar between transgenic PKG‐I mice and WT controls. Together, these data demonstrate sex differences in effects of PKG‐I activation on the regulation of adipose tissue function and its contribution to diet induced obesity.
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Brown adipose tissue is metabolically more active than white adipose tissue and its distribution changes with age.
“Brown adipose (BAT) tissue is metabolically more active than white adipose tissue and its distribution changes with age.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [122]
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- Authors
- Nikolic, D. M., Li, Y., Liu, S., & Wang, S.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Wang, Shuxia
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2011-04
- Volume
- 19
- Issue
- 4
- Pages
- 784-791
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC9125568
- OpenAlex
- W1970061718
- Cited by
- 30
- References
- 33
- Citations by year
- 2025: 1 · 2024: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 8 · 2012: 1
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p20rr021954-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK081555)
- National Center for Research Resources (P20-RR021954)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- cGMP-dependent protein kinase I, diet-induced obesity, sex differences, high-fat diet, adipose tissue, energy homeostasis, glucose tolerance, adaptive thermogenesis, brown adipose tissue, UCP1, white adipose tissue lipolysis, hormone-sensitive lipase, transgenic mice
- MeSH terms
- Uncoupling Protein 1, Analysis of Variance, Animals, Body Composition, Body Weight, Adipose Tissue, Brown, Sterol Esterase, Diet, Dietary Fats, Eating, Energy Metabolism, Female, Glucose Tolerance Test, Ion Channels, Lipolysis, Male, Mice, Transgenic, Obesity, Sex Factors, Cyclic GMP-Dependent Protein Kinases, Thermogenesis, Mitochondrial Proteins, Adiposity, Mice, Adipose Tissue, White
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