Cited by 197Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Involvement of Sex, Strain and Age Factors in High Fat Diet-Induced Obesity in C57BL/6J and BALB/cA Mice

Open access
NISHIKAWA, Satomi, YASOSHIMA, Akira, DOI, Kunio, NAKAYAMA, Hiroyuki, UETSUKA, Koji·2007·Experimental Animals

Abstract

Although a number of obesity animal models have been reported, each model possesses different characteristics of obesity, suggesting care should be taken in choosing an animal model suitable for the experimental purpose. In this report, we fed 4-(young) and 52-week-old (middle-aged) C57BL/6J (B6) and young BALB/cA (BALB/c) mice with a high fat diet (HFD) for 9 weeks, and investigated the clinical and histological characteristics of obesity. In BALB/c mice, males gained more body weight and body fat weight and had higher energy intake than females by HFD feeding. Comparing the effect of HFD feeding between the strains of mice, BALB/c male mice accumulated more hepatic lipid than B6 male mice. In addition, middle-aged B6 mice increased the ratio of fat to body weight and hepatic lipid accumulation more than young mice. In conclusion, the characteristics of obesity induced by HFD feeding were influenced by the sex, strain and age of mice. Sex steroid hormones, hepatic lipid metabolism and systemic metabolism might be involved in these factors. The basic data in this study will be useful for the development of animal models of high fat diet-induced obesity.

Integrity signals

Registry

Crossref · 10.1538/expanim.56.263

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several strains of female mice are relatively resistant to obesity on a high-fat diet, but this protection can be removed by ovariectomy.

    “Furthermore, unlike their male counterparts, several strains of female mice are relatively resistant to obesity on a high-fat diet [54, 55], but this protection can be removed by ovariectomy [56, 57].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
NISHIKAWA, S., YASOSHIMA, A., DOI, K., NAKAYAMA, H., & UETSUKA, K.
Affiliations
The University of Tokyo (JP)
Venue
Experimental Animals
Published
2007
Volume
56
Issue
4
Pages
263-272
ISSN
  • 0007-5124 (ISSN-L)
  • 1341-1357
  • 1881-7122
OpenAlex
W2066332959
Cited by
197
References
20
Citations by year
2026: 5 · 2025: 13 · 2024: 9 · 2023: 17 · 2022: 15 · 2021: 17 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 8
FWCI
3.91
Type
journal article
Language
en
Open access
Locations
  • EXPERIMENTAL ANIMALS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
high-fat diet-induced obesity, animal models of obesity, sex differences, strain differences, age effects, C57BL/6J mice, BALB/c mice, hepatic lipid accumulation, body fat accumulation, energy intake, sex hormones, hepatic lipid metabolism
MeSH terms
Adipose Tissue, Age Factors, Animals, Body Weight, Dietary Fats, Disease Models, Animal, Female, Glucose Tolerance Test, Liver, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Obesity, Organ Size, Sex Factors, Species Specificity, Lipid Metabolism, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review