The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
Open accessAbstract
There is a growing consensus that the various forms of cell death (necrosis, apoptosis and autophagy) are not separated by strict boundaries, but rather share molecular effectors and signaling routes. Among the latter, a clear role is played by calcium (Ca2+), the ubiquitous second messenger involved in the control of a broad variety of physiological events. Fine tuning of intracellular Ca2+ homeostasis by anti- and proapoptotic proteins shapes the Ca2+ signal to which mitochondria and other cellular effectors are exposed, and hence the efficiency of various cell death inducers. Here, we will review: (i) the evidence linking calcium homeostasis to the regulation of apoptotic, and more recently autophagic cell death, (ii) the discussion of mitochondria as a critical, although not unique checkpoint and (iii) the molecular and functional elucidation of ER/mitochondria contacts, corresponding to the mitochondria-associated membrane (MAM) subfraction and proposed to be a specialized signaling microdomain.
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Li, W., Yang, J., Luo, L., Jiang, M., Qin, B., Yin, H., Zhu, C., Yuan, X., Zhang, J., Luo, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11269-8 · Cited by 1,120
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Arruda, A. P., Pers, B. M., Parlakgül, G., Güney, E., Inouye, K., & Hotamisligil, G. S. (2014) · Nature Medicine · doi:10.1038/nm.3735 · Cited by 720
Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
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Metadata
- Authors
- Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., & Rizzuto, R.
- Venue
- Oncogene
- Published
- 2008-10-27
- Volume
- 27
- Issue
- 50
- Pages
- 6407-6418
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2131387907
- Cited by
- 1,157
- References
- 131
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., & Rizzuto, R. (2008). Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene. https://doi.org/10.1038/onc.2008.308
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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