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Human papillomaviruses, cervical cancer and cell polarity

Thomas, M, Narayan, N, Pim, D, Tomaić, V, Massimi, P, Nagasaka, K, Kranjec, C, Gammoh, N, Banks, L·2008·Oncogene
DOI 10.1038/onc.2008.351
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Abstract

Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, of which cervical cancer is the most important. This occurs following persistent infection with a limited number of viral subtypes and is characterized by continued expression of the viral E6 and E7 oncoproteins. A unique characteristic of the cancer-causing HPV types is the presence of a PDZ recognition motif on the carboxy terminus of the E6 oncoprotein. Through this motif, E6 directs the proteasome-mediated degradation of cellular proteins involved in the regulation of cell polarity and in cell proliferation control. These include components of the Scrib and Par polarity complexes, as well as a number of other PDZ domain-containing substrates. Thus, PVs are now providing novel insights into the functioning of many of these cellular proteins, and into which of these functions, in particular, are relevant for maintaining normal cellular homeostasis. In this review, we discuss the biological consequences of papillomaviral targeting of these cell polarity regulators, both with respect to the viral life cycle and, most importantly, to the development of HPV-induced malignancy.

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Cited by

Metadata

Authors
Thomas, M., Narayan, N., Pim, D., Tomaić, V, Massimi, P., Nagasaka, K., Kranjec, C., Gammoh, N., & Banks, L.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2008-11-24
Volume
27
Issue
55
Pages
7018-7030
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/onc.2008.351
Cited by
163
References
7
Language
en
Licence

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