The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
Open accessAbstract
MicroRNAs (miRNAs) are important regulators of cell fate determination and homeostasis. Expression of these small RNA genes is tightly regulated during development and in normal tissues, but they are often misregulated in cancer. MiRNA expression is also affected by DNA damaging agents, such as radiation. In particular, mammalian miR-34 is upregulated by p53 in response to radiation, but little is known about the role of this miRNA in vivo. Here we show that Caenorhabditis elegans with loss-of-function mutations in the mir-34 gene have an abnormal cellular survival response to radiation; these animals are highly radiosensitive in the soma and radioresistant in the germline. These findings show a role for mir-34 in both apoptotic and non-apoptotic cell death in vivo, much like that of cep-1, the C. elegans p53 homolog. These results have been additionally validated in vitro in breast cancer cells, wherein exogenous addition of miR-34 alters cell survival post-radiation. These observations confirm that mir-34 is required for a normal cellular response to DNA damage in vivo resulting in altered cellular survival post-irradiation, and point to a potential therapeutic use for anti-miR-34 as a radiosensitizing agent in p53-mutant breast cancer.
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Cites
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×
“In some cases, cancer risk is enhanced by inherited mutations in genes important in the DDR, such as p53, BRCA, etc. (Miki et al., 1994; Vogelstein et al., 2000).”
BackgroundMicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · cited 1×
“This is the first demonstration that mir-34 plays a role in the response to radiation in vivo and is the first known phenotype associated with mir-34 deletion mutants in C. elegans (Miska et al., 2007) or in any animals.”
BackgroundHui, L., Zheng, Y., Yan, Y., Bargonetti, J., & Foster, D. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209735 · Cited by 218
Cited by
Trang, P., Wiggins, J. F., Daige, C. L., Cho, C., Omotola, M., Brown, D., Weidhaas, J. B., Bader, A. G., & Slack, F. J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.48 · Cited by 667
Self-citationMicroRNA-34a: a potential therapeutic target in human cancer
Li, X. J., Ren, Z. J., & Tang, J. H. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.270 · Cited by 287
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence
Noren Hooten, N., Martin‐Montalvo, A., Dluzen, D. F., Zhang, Y., Bernier, M., Zonderman, A. B., Becker, K. G., Gorospe, M., Cabo, R., & Evans, M. K. (2016) · Aging Cell · doi:10.1111/acel.12469 · Cited by 196
Fractionated Radiation Alters Oncomir and Tumor Suppressor miRNAs in Human Prostate Cancer Cells
John-Aryankalayil, M., Palayoor, S. T., Makinde, A. Y., Cerna, D., Simone, C. B., Falduto, M. T., Magnuson, S. R., & Coleman, C. N. (2012) · Radiation Research · doi:10.1667/rr2703.1 · Cited by 75
Metadata
- Authors
- Kato, M., Paranjape, T., Ullrich, R., Nallur, S., Gillespie, E., Keane, K., Esquela-Kerscher, A., Weidhaas, J. B., & Slack, F. J.
- Venue
- Oncogene
- Published
- 2009-05-04
- Volume
- 28
- Issue
- 25
- Pages
- 2419-2424
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2051936739
- Cited by
- 240
- References
- 4
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Kato, M., Paranjape, T., Ullrich, R., Nallur, S., Gillespie, E., Keane, K., Esquela-Kerscher, A., Weidhaas, J. B., & Slack, F. J. (2009). The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene. https://doi.org/10.1038/onc.2009.106
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