The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
Open accessAbstract
Small molecule inhibitors that selectively target cancer cells and not normal cells would be valuable anti-cancer therapeutics. The mammalian target of rapamycin complex 2 (mTORC2) is emerging as a promising candidate target for such an inhibitor. Recent studies in cancer biology indicate that mTORC2 activity is essential for the transformation and vitality of a number of cancer cell types, but in many normal cells, mTORC2 activity is less essential. These studies are intensifying interest in developing inhibitors that specifically target mTORC2. However, there are many open questions regarding the function and regulation of mTORC2 and its function in both normal and cancer cells. Here, we summarize exciting new research into the biology of mTORC2 signaling and highlight the current state and future prospects for mTOR-targeted therapy.
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Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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Self-citationAKT/PKB signaling: navigating downstream
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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
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“Interestingly, there is an emerging function for the TSC1–TSC2 complex in positively regulating mTORC2 (Huang et al., 2008, 2009).”
BackgroundPeterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., & Sabatini, D. M. (2009) · Cell · doi:10.1016/j.cell.2009.03.046 · Cited by 1,202
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“Skeletal muscle is the first tissue in which mTORC2 activity has been conditionally ablated by Cre-mediated deletion of rictor ‘floxed’ alleles (Bentzinger et al., 2008; Kumar et al., 2008).”
Background
Cited by
MTOR: a pharmacologic target for autophagy regulation
Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.026 · Cited by 1,241
Making new contacts: the mTOR network in metabolism and signalling crosstalk
Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053
Activation of mTORC2 by Association with the Ribosome
Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011) · Cell · doi:10.1016/j.cell.2011.02.014 · Cited by 654
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging
Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544
Metadata
- Authors
- Sparks, C. A., & Guertin, D. A.
- Venue
- Oncogene
- Published
- 2010-04-26
- Volume
- 29
- Issue
- 26
- Pages
- 3733-3744
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1999211774
- Cited by
- 299
- References
- 11
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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