The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis
Open accessAbstract
The role of the fibronectin receptor, α5β1-integrin, as an adhesion receptor and in angiogenesis is well established. However, its role in cancer cell invasion and metastasis is less clear. We describe a novel mechanism by which fibronectin regulates ovarian cancer cell signaling and promotes metastasis. Fibronectin binding to α5β1-integrin led to a direct association of α5-integrin with the receptor tyrosine kinase, c-Met, activating it in a hepatocyte growth factor/scatter factor (HGF/SF) independent manner. Subsequently, c-Met associated with Src, and activated Src and focal adhesion kinase (FAK). Inhibition of α5β1-integrin decreased the phosphorylation of c-Met, FAK and Src, both in vitro and in vivo. Independent activation of c-Met by its native ligand, HGF/SF, or overexpression of a constitutively active FAK in HeyA8 cells could overcome the effect of α5β1-integrin inhibition on tumor cell invasion, indicating that α5β1-integrin is upstream of c-Met, Src and FAK. Inhibition of α5β1-integrin on cancer cells in two xenograft models of ovarian cancer metastasis resulted in a significant decrease of tumor burden, which was independent of the effect of α5β1-integrin on angiogenesis. These data suggest that fibronectin promotes ovarian cancer invasion and metastasis through an α5β1-integrin/c-Met/FAK/Src-dependent signaling pathway, transducing signals through c-Met in an HGF/SF-independent manner.
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Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Met, metastasis, motility and more
Birchmeier, C., Birchmeier, W., Gherardi, E., & Vande Woude, G. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1261 · Cited by 2,602
Ovarian Cancer Development and Metastasis
Lengyel, E. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100105 · Cited by 1,672
Self-citationIntegrin-regulated FAK–Src signaling in normal and cancer cells
Mitra, S. K., & Schlaepfer, D. D. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.08.011 · Cited by 1,590
Integrins in angiogenesis and lymphangiogenesis
Avraamides, C. J., Garmy-Susini, B., & Varner, J. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2353 · Cited by 1,050
Embryonic mesodermal defects in α5 integrin-deficient mice
Yang, J. T., Rayburn, H., & Hynes, R. O. (1993) · Development · doi:10.1242/dev.119.4.1093 · Cited by 691
Kim, S., Bell, K., Mousa, S. A., & Varner, J. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65005-5 · Cited by 635
A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth
Trusolino, L., Bertotti, A., & Comoglio, P. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00567-0 · Cited by 420
Rab25 Associates with α5β1 Integrin to Promote Invasive Migration in 3D Microenvironments
Caswell, P. T., Spence, H. J., Parsons, M., White, D. P., Clark, K., Cheng, K. W., Mills, G. B., Humphries, M. J., Messent, A. J., Anderson, K. I., et al. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.012 · Cited by 387
Cited by
Every step of the way: integrins in cancer progression and metastasis
Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493
Activation of fibroblasts in cancer stroma
Räsänen, K., & Vaheri, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.032 · Cited by 499
Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche
Brizzi, M. F., Tarone, G., & Defilippi, P. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.07.001 · Cited by 412
Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
Iwanicki, M. P., Davidowitz, R. A., Ng, M. R., Besser, A., Muranen, T., Merritt, M., Danuser, G., Ince, T., & Brugge, J. S. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-11-0010 · Cited by 303
Mesothelial Cells Promote Early Ovarian Cancer Metastasis through Fibronectin Secretion
Kenny, H. A., Chiang, C.-Y., White, E. A., Schryver, E. M., Habis, M., Romero, I. L., Ladanyi, A., Penicka, C. V., George, J., Matlin, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74778 · Cited by 303
Self-citation
Metadata
- Authors
- Mitra, A. K., Sawada, K., Tiwari, P., Mui, K., Gwin, K., & Lengyel, E.
- Venue
- Oncogene
- Published
- 2010-11-29
- Volume
- 30
- Issue
- 13
- Pages
- 1566-1576
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2025880272
- Cited by
- 274
- References
- 38
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Mitra, A. K., Sawada, K., Tiwari, P., Mui, K., Gwin, K., & Lengyel, E. (2011). Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis. Oncogene. https://doi.org/10.1038/onc.2010.532
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