Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche
Abstract
It is widely acknowledged that integrins, the major receptors for the extracellular matrix (ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors. Among them, growth factor receptors, such as the EGFR, MET, PDGFR and VEGFR, and the IL-3 receptor have been shown to be physically and functionally associated to integrins. The connection between integrins and other transmembrane receptors is bidirectional, integrins being essential for receptor signalling, and receptors being involved in regulation of integrin expression or activation. Moreover, there is accumulating evidence for direct binding of specific growth factors and morphogens to the ECM proteins, suggesting that ECM might spatially integrate different types of signals in a specific microenvironment, facilitating integrin/transmembrane receptors connection. These interactions are crucial in controlling a variety of cell behaviours including proliferation, survival and differentiation. The increasing interest for cell therapy in regenerative medicine has recently emphasized the role of cell-ECM adhesion as stem cell determinant. The relevance of ECM, integrins and growth factor receptor network in the establishment of stem cell niche, in maintenance of stem cells and in their differentiation will be analyzed in the present review.
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Fibroblasts participate in crosstalk with adjacent epithelia and can influence local epithelial stem cell behaviour.
“Both in normal homeostasis and following injury they participate in crosstalk with adjacent epithelia, with numerous studies documenting an ability to influence local epithelial stem cell behaviour13,14.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [13]
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works
Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.-M., Goderie, S. K., Roysam, B., & Temple, S. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.026 · Cited by 1,027 · see citing works
Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing
Margadant, C., & Sonnenberg, A. (2010) · The EMBO Reports · doi:10.1038/embor.2009.276 · Cited by 653 · cited 2× · see citing works
“Integrins belonging to the beta1, alphav, beta7 and beta4 subfamilies have been shown to potentiate signalling pathways in response to many growth factors (reviewed in [2–5]), IL-3 [6,7] and TGFbeta (reviewed in [5,8]).”
BackgroundCell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384 · see citing works
Domains of laminin with growth-factor activity
Panayotou, G., End, P., Aumailley, M., Timpl, R., & Engel, J. (1989) · Cell · doi:10.1016/0092-8674(89)90987-2 · Cited by 341 · see citing works
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Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468 · see citing works
Role of the extracellular matrix in regulating stem cell fate
Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3620 · Cited by 861 · see citing works
Biology of the Extracellular Matrix: An Overview
Yue, B. (2014) · Journal of Glaucoma · doi:10.1097/ijg.0000000000000108 · Cited by 805 · see citing works
Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Ménard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.032 · Cited by 462 · see citing works
Liu, H., Peng, H., Wu, Y., Zhang, C., Cai, Y., Xu, G., Li, Q., Chen, X., Ji, J., Zhang, Y., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.048 · Cited by 339 · see citing works
The outer subventricular zone and primate-specific cortical complexification
Dehay, C., Kennedy, H., & Kosik, K. S. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.060 · Cited by 314 · see citing works
Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness
Mu, W., Rana, S., & Zöller, M. (2013) · Neoplasia · doi:10.1593/neo.13786 · Cited by 248 · see citing works
Molecular mechanisms of stem/progenitor cell maintenance in the adrenal cortex
Lerario, A. M., Finco, I., LaPensee, C., & Hammer, G. D. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00052 · Cited by 68 · see citing works
Wang, T., Lai, J. H., Han, L.-H., Tong, X., & Yang, F. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0531 · Cited by 70 · see citing works
Fotsitzoudis, C., Koulouridi, A., Messaritakis, I., Konstantinidis, T., Gouvas, N., Tsiaoussis, J., & Souglakos, J. (2022) · Cancers · doi:10.3390/cancers14184394 · Cited by 46 · see citing works
Choi, H.-R., Shin, J.-W., Na, J.-I., Nam, K.-M., Lee, H.-S., & Park, K.-C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/359740 · Cited by 9 · see citing works
- Authors
- Brizzi, M. F., Tarone, G., & Defilippi, P.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Defilippi, Paola
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 24
- Issue
- 5
- Pages
- 645-651
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2131631451
- Cited by
- 412
- References
- 7
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 22 · 2023: 31 · 2022: 31 · 2021: 29 · 2020: 41 · 2019: 18 · 2018: 44 · 2017: 33 · 2016: 36 · 2015: 40 · 2014: 32 · 2013: 32 · 2012: 2
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- extracellular matrix, integrins, growth factor receptors, stem cell niche, cell-matrix adhesion, receptor signaling, EGFR, MET, PDGFR, VEGFR, IL-3 receptor, stem cell maintenance, stem cell differentiation, cell therapy, regenerative medicine, morphogens
- MeSH terms
- Animals, Cell Differentiation, Cell Membrane, Extracellular Matrix, Humans, Stem Cells, Integrins, Extracellular Matrix Proteins, Receptors, Growth Factor, Pliability, Integrin beta1, Cell Lineage, Intercellular Signaling Peptides and Proteins, Stem Cell Niche
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