The IARC TP53 database: new online mutation analysis and recommendations to users

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

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p53 and Human Cancer: The First Ten Thousand Mutations

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Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

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Database of p53 gene somatic mutations in human tumors and cell lines.

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

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p53 gene mutation: software and database

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p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.

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p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer

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p53 and the Li-Fraumeni syndrome

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p53 gene mutation: software and database

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Mutation analysis of the CHK2gene in families with hereditary breast cancer

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A database of germline p53 mutations in cancer-prone families

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Sources of bias in the detection and reporting of p53 mutations in human cancer: analysis of the IARC p53 mutation database

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Untitled work

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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Restoration of p53 function leads to tumour regression in vivo

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Impact of mutant p53 functional properties on <i>TP53</i> mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

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Small-cell lung cancer

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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes

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mCSM: Predicting the effects of mutations in proteins using graph-based signatures

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Principles of Tumor Suppression

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Targeting p53 pathways: mechanisms, structures, and advances in therapy

Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works

TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes

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Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

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p53: 800 million years of evolution and 40 years of discovery

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Mutations induced by ultraviolet light

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Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel

González-Pérez, A., & López-Bigas, N. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.004 · Cited by 765 · see citing works

Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

Issaeva, N., Bozko, P. M., Enge, M., Protopopova, M., Verhoef, L. G. G. C., Masucci, M. G., Pramanik, A., & Selivanova, G. (2004) · Nature Medicine · doi:10.1038/nm1146 · Cited by 749 · see citing works

PDL1 Regulation by p53 via miR-34

Cortez, M. A., Ivan, C., Valdecanas, D., Wang, X., Peltier, H. J., Ye, Y., Araujo, L., Carbone, D. P., Shilo, K., Giri, D. K., et al. (2016) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djv303 · Cited by 683 · see citing works

BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

Patton, E. E., Widlund, H. R., Kutok, J. L., Kopani, K. R., Amatruda, J. F., Murphey, R. D., Berghmans, S., Mayhall, E. A., Traver, D. J., Fletcher, C. D. �., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.031 · Cited by 666 · see citing works

Chemical basis of inflammation-induced carcinogenesis

Ohshima, H., Tatemichi, M., & Sawa, T. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00283-2 · Cited by 618 · see citing works

RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators

Harris, R. S., Petersen‐Mahrt, S. K., & Neuberger, M. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00742-6 · Cited by 604 · see citing works

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

Grollman, A. P., Shibutani, S., Moriya, M., Miller, F. W., Wu, L., Moll, U. M., Suzuki, N., Fernandes, A., Rosenquist, T. A., Medverec, Z., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701248104 · Cited by 603 · see citing works

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

Berghmans, S., Murphey, R. D., Wienholds, E., Neuberg, D. S., Kutok, J. L., Fletcher, C. D. �., Morris, J. P., Liu, T. X., Schulte‐Merker, S., Kanki, J. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406252102 · Cited by 599 · see citing works

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

Lambert, J. M. R., Gorzov, P., Veprintsev, D. B., Söderqvist, M., Segerbäck, D., Bergman, J., Fersht, A. R., Hainaut, P., Wiman, K. G., & Bykov, V. J. N. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.003 · Cited by 592 · see citing works

Transcriptional Regulation by P53

Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569 · see citing works

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

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Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats

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The Differential Effects of Mutant <i>p53</i> Alleles on Advanced Murine Lung Cancer

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Xu, J., Reumers, J., Couceiro, J. R., De Smet, F., Gallardo, R., Rudyak, S., Cornelis, A., Rozenski, J., Zwolinska, A., Marine, J.-C., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.546 · Cited by 543 · see citing works

Small-cell lung cancer

Jackman, D. M., & Johnson, B. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67569-1 · Cited by 504 · see citing works

Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth

Gaglio, D., Metallo, C. M., Gameiro, P. A., Hiller, K., Danna, L. S., Balestrieri, C., Alberghina, L., Stephanopoulos, G., & Chiaradonna, F. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.56 · Cited by 492 · see citing works

Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li‐Fraumeni syndrome cohort

Mai, P. L., Best, A. F., Peters, J. A., DeCastro, R. M., Khincha, P. P., Loud, J. T., Bremer, R. C., Rosenberg, P. S., & Savage, S. A. (2016) · Cancer · doi:10.1002/cncr.30248 · Cited by 487 · see citing works

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype.

Olivier, M., Goldgar, D. E., Sodha, N., Ohgaki, H., Kleihues, P., Hainaut, P. L., & Eeles, R. A. (2003) · PubMed · Cited by 480 · see citing works

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

Klein, C. A., Blankenstein, T. J. F., Schmidt‐Kittler, O., Petronio, M., Polzer, B. M., Stoecklein, N. H., & Riethmüller, G. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09838-0 · Cited by 479 · see citing works

Gallbladder cancer: lessons from a rare tumour

Wistuba, I. I., & Gazdar, A. F. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1429 · Cited by 458 · see citing works

Small Cell Lung Cancer

Kalemkerian, G. P., Akerley, W., Bogner, P., Borghaei, H., Chow, L. Q., Downey, R. J., Gandhi, L., Ganti, A. K. P., Govindan, R., Grecula, J. C., et al. (2013) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2013.0011 · Cited by 440 · see citing works

Structure–function–rescue: the diverse nature of common p53 cancer mutants

Joerger, A. C., & Fersht, A. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210291 · Cited by 430 · see citing works

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

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Structural Basis of DNA Recognition by p53 Tetramers

Kitayner, M., Rozenberg, H., Kessler, N., Rabinovich, D., Shaulov, L., Haran, T. E., & Shakked, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.015 · Cited by 408 · see citing works

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study

Villani, A., Tabori, U. Y., Schiffman, J. D., Shlien, A., Beyene, J., Druker, H. A., Novokmet, A., Finlay, J. L., & Malkin, D. M. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70119-x · Cited by 420 · see citing works

Aristolochic acid-associated urothelial cancer in Taiwan

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Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severityPreprint

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TP53 Mutations in Nonsmall Cell Lung Cancer

Mogi, A., & Kuwano, H. (2011) · BioMed Research International · doi:10.1155/2011/583929 · Cited by 392 · see citing works

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

Boeckler, F. M., Joerger, A. C., Jaggi, G., Rutherford, T. J., Veprintsev, D. B., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805326105 · Cited by 389 · see citing works

Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclassification

Röwert‐Huber, J., Patel, M. J., Forschner, T., Ulrich, C., Eberle, J., Kerl, H., Sterry, W., & Stockfleth, E. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07860.x · Cited by 381 · see citing works

Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

Feng, Z., Hu, W., Hu, Y., & Tang, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607031103 · Cited by 374 · see citing works

TP53and breast cancer

Børresen‐Dale, A. (2003) · Human Mutation · doi:10.1002/humu.10174 · Cited by 355 · see citing works

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

Joerger, A. C., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607286103 · Cited by 354 · see citing works

Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

Beale, R. C. L., Petersen‐Mahrt, S. K., Watt, I. N., Harris, R. S., Rada, C. A., & Neuberger, M. S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.01.046 · Cited by 337 · see citing works

Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

Mathé, E. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj518 · Cited by 340 · see citing works

Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview

Wang, L., Wu, C., Rajasekaran, N., & Shin, Y. K. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495956 · Cited by 334 · see citing works

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Stephens, P., Edkins, S., Davies, H. R., Greenman, C., Cox, C., Hunter, C., Bignell, G. R., Teague, J. W., Smith, R., Stevens, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1571 · Cited by 333 · see citing works

COSMIC 2005

Forbes, S. A., Clements, J., Dawson, E., Bamford, S., Webb, T., Doǧan, A., Flanagan, A. M., Teague, J. W., Wooster, R., Futreal, P. A., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602928 · Cited by 327 · see citing works

Prognostic and Predictive Importance of p53 and RAS for Adjuvant Chemotherapy in Non–Small-Cell Lung Cancer

Tsao, M., Aviel‐Ronen, S., Ding, K., Lau, D., Liu, G., Sakurada, A., Whitehead, M., Zhu, C., Livingston, R. B., Johnson, D. H., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.6953 · Cited by 326 · see citing works

Association of k-ras, b-raf, and p53 Status With the Treatment Effect of Bevacizumab

Ince, W. L., Jubb, A. M., Holden, S. N., Holmgren, E. B., Tobin, P., Sridhar, M., Hurwitz, H. I., Kabbinavar, F. F., Novotny, W. F., Hillan, K. J., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji174 · Cited by 318 · see citing works

Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour

Scott, R. H., Stiller, C. A., Walker, L., & Rahman, N. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.041723 · Cited by 313 · see citing works

The p53 family and programmed cell death

Pietsch, E. C., Sykes, S. M., McMahon, S. B., & Murphy, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.315 · Cited by 314 · see citing works

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinasesPreprint

Lefort, K., Mandinova, A., Ostano, P., Kolev, V. N., Calpini, V., Kolfschoten, I., Devgan, V., Lieb, J., Raffoul, W., Hohl, D., et al. (2007) · Genes & Development · doi:10.1101/gad.1484707 · Cited by 307 · see citing works

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

Chipuk, J. E., Maurer, U., Green, D. R., & Schüler, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00272-1 · Cited by 297 · see citing works

Breast tumor copy number aberration phenotypes and genomic instability

Fridlyand, J., Snijders, A. M., Ylstra, B., Li, H., Olshen, A. B., Segraves, R., Dairkee, S. H., Tokuyasu, T. A., Ljung, B., Jain, A. N., et al. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-96 · Cited by 298 · see citing works

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

Sur, S., Pagliarini, R. A., Bunz, F., Rago, C., Diaz, L. A., Kinzler, K. W., Vogelstein, B., & Papadopoulos, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813333106 · Cited by 293 · see citing works

Aristolochic Acid and ???Chinese Herbs Nephropathy???

Cosyns, J. (2003) · Drug Safety · doi:10.2165/00002018-200326010-00004 · Cited by 283 · see citing works

Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis

Herceg, Z., & Hainaut, P. L. (2007) · Molecular Oncology · doi:10.1016/j.molonc.2007.01.004 · Cited by 282 · see citing works

TheTP53 gene, tobacco exposure, and lung cancer

Toyooka, S., Tsuda, T., & Gazdar, A. F. (2003) · Human Mutation · doi:10.1002/humu.10177 · Cited by 275 · see citing works

<i>TP53</i> and <i>KRAS</i> Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers

Le Calvez, F., Mukeria, A., Hunt, J. D., Kelm, O., Hung, R. J., Tanière, P., Brennan, P., Boffetta, P., Zaridze, D. G., & Hainaut, P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0551 · Cited by 273 · see citing works

Mutant p53: an oncogenic transcription factor

Strano, S., Dell’Orso, S., Agostino, S. D., Fontemaggi, G., Sacchi, A., & Blandino, G. (2007) · Oncogene · doi:10.1038/sj.onc.1210296 · Cited by 270 · see citing works

Mutagenesis at Methylated CpG Sequences

Pfeifer, G. P. (2006) · Springer eBooks · doi:10.1007/3-540-31390-7_10 · Cited by 267 · see citing works

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia

Langenau, D. M., Feng, H., Berghmans, S., Kanki, J. P., Kutok, J. L., & Look, A. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408708102 · Cited by 259 · see citing works

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines

Liu, Y., & Bodmer, W. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510146103 · Cited by 257 · see citing works

MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents

Monte, M., Simonatto, M., Peche, L. Y., Bublik, D. R., Gobessi, S., Pierotti, M. A., Rodolfo, M., & Schneider, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510834103 · Cited by 257 · see citing works

Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants

Hocker, T. L. H., & Tsao, H. (2007) · Human Mutation · doi:10.1002/humu.20481 · Cited by 256 · see citing works

NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma

Galipeau, P. C., Li, X., Blount, P. L., Maley, C. C., Sanchez, C. A., Odze, R. D., Ayub, K., Rabinovitch, P. S., Vaughan, T. L., & Reid, B. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040067 · Cited by 250 · see citing works

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

Mahmoudi, S., Henriksson, S., Corcoran, M., Méndez‐Vidal, C., Wiman, K. G., & Farnebo, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.027 · Cited by 250 · see citing works

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

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Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

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