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Molecular mechanisms of cisplatin resistance
Abstract
Platinum-based drugs, and in particular cis-diamminedichloroplatinum(II) (best known as cisplatin), are employed for the treatment of a wide array of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response and the induction of mitochondrial apoptosis. Despite a consistent rate of initial responses, cisplatin treatment often results in the development of chemoresistance, leading to therapeutic failure. An intense research has been conducted during the past 30 years and several mechanisms that account for the cisplatin-resistant phenotype of tumor cells have been described. Here, we provide a systematic discussion of these mechanism by classifying them in alterations (1) that involve steps preceding the binding of cisplatin to DNA (pre-target resistance), (2) that directly relate to DNA-cisplatin adducts (on-target resistance), (3) concerning the lethal signaling pathway(s) elicited by cisplatin-mediated DNA damage (post-target resistance) and (4) affecting molecular circuitries that do not present obvious links with cisplatin-elicited signals (off-target resistance). As in some clinical settings cisplatin constitutes the major therapeutic option, the development of chemosensitization strategies constitute a goal with important clinical implications.
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“Also, constant or prolonged cisplatin treatment often results in the acquisition of resistance through the selection bias of alternative cell survival pathways, leading to therapeutic failure and poor prognosis [9, 10].”
From Advances in platinum-based cancer therapy: overcoming platinum resistance through rational combinatorial strategies (2025) · cites this paper as [9]
In the citing paper
“Mechanistically, cells can prevent cisplatin from reaching and harming DNA by reducing drug uptake, increasing drug efflux, and inactivating the drug through covalent binding to glutathione or metalloproteins [9, 10].”
From Advances in platinum-based cancer therapy: overcoming platinum resistance through rational combinatorial strategies (2025) · cites this paper as [9]
In the citing paper
“However, mitotic catastrophe appears to constitute a major mechanism of action of anticancer chemotherapeutics, mostly reflecting the increased resistance of neoplastic cells to the induction of intrinsic apoptosis [1004–1009].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [1007]
Citations
Cites
Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
Slamon, D. J., Godolphin, W. J., Jones, L. A., Holt, J. A., Wong, S., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. A., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,817
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
The resurgence of platinum-based cancer chemotherapy
Kèlland, L. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2167 · Cited by 4,733
de Gramont, A., Figer, A., Seymour, M., Homerin, M., Hmissi, A., Cassidy, J., Boni, C., Cortes-Funes, H., Cervantes, A., Freyer, G., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.16.2938 · Cited by 3,815
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Self-citationAutophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Self-citationCisplatin: mode of cytotoxic action and molecular basis of resistance
Siddik, Z. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206933 · Cited by 3,335
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
Self-citationStructure, Recognition, and Processing of Cisplatin−DNA Adducts
Jamieson, E. R., & Lippard, S. J. (1999) · Chemical Reviews · doi:10.1021/cr980421n · Cited by 2,953
Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer
Armstrong, D. K., Bundy, B. N., Wenzel, L. B., Huang, H. Q., Baergen, R. N., Lele, S., Copeland, L. J., Walker, J. L., & Burger, R. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052985 · Cited by 2,626
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351
Goldberg, R. M., Sargent, D. J., Morton, R. F., Fuchs, C. S., Ramanathan, R. K., Williamson, S. K., Findlay, B., Pitot, H. C., & Alberts, S. R. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.046 · Cited by 2,251
EGF–ERBB signalling: towards the systems level
Citri, A., & Yarden, Y. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1962 · Cited by 2,056
A family of drug transporters: the multidrug resistance-associated proteins
Borst, P., Evers, R., Kool, M., & Wijnholds, J. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.16.1295 · Cited by 1,751
DNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy
Olaussen, K. A., Dunant, A., Fouret, P. J., Brambilla, E. M., André, F., Haddad, V., Clermont, E., Filipits, M., Pirker, R., Popper, H., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060570 · Cited by 1,725
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713
Giacchetti, S., Perpoint, B., Zidani, R., Bail, N. L., Faggiuolo, R., Focan, C., Chollet, P. J. M., Llory, J., Letourneau, Y., Coudert, B. P., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.1.136 · Cited by 1,404
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,372
The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer
Smith, J., Tho, L. M., Xu, N., & Gillespie, D. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00003-0 · Cited by 1,331
Immunogenic death of colon cancer cells treated with oxaliplatin
Tesnière, A., Schlemmer, F., Boige, V., Kepp, O., Martins, I., Ghiringhelli, F., Aymeric, L., Michaud, M., Apétoh, L., Barault, L., et al. (2009) · Oncogene · doi:10.1038/onc.2009.356 · Cited by 1,224
Self-citationZhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,148
Post‐translational modifications and activation of p53 by genotoxic stresses
Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,095
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Sakai, W., Swisher, E. M., Karlan, B. Y., Agarwal, M. K., Higgins, J., Friedman, C., Villegas, E., Jacquemont, C., Farrugia, D. J., Couch, F. J., et al. (2008) · Nature · doi:10.1038/nature06633 · Cited by 1,086
Resistance to therapy caused by intragenic deletion in BRCA2
Edwards, S. L., Brough, R., Lord, C. J., Natrajan, R., Vatcheva, R., Levine, D. A., Boyd, J., Reis-Filho, J. S., & Ashworth, A. (2008) · Nature · doi:10.1038/nature06548 · Cited by 1,011
Survivin, cancer networks and pathway-directed drug discovery
Altieri, D. C. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2293 · Cited by 1,000
Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972
BRCA1 and BRCA2: 1994 and beyond
Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
Ishida, S., Lee, J., Thiele, D. J., & Herskowitz, I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162491399 · Cited by 927
O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., et al. (1997) · PubMed · Cited by 867
Mitotic catastrophe: a mechanism for avoiding genomic instability
Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834
Self-citationLebwohl, D., & Canetta, R. M. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00224-x · Cited by 756
Requirement for ERK Activation in Cisplatin-induced Apoptosis
Wang, X., Martindale, J. L., & Holbrook, N. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004583200 · Cited by 678
Cui, Y., König, J., Buchholz, U., Spring, H., Leier, I., & KEPPLER, D. O. R. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23190-4 · Cited by 674
The ATP-dependent glutathione S-conjugate export pump
Ishikawa, T. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90489-v · Cited by 658
Rothenberg, M. L., Oza, A. M., Bigelow, R., Berlin, J. D., Marshall, J. L., Ramanathan, R. K., Hart, L. L., Gupta, S., Garay, C. A., Burger, B., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.11.126 · Cited by 646
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642 · cited 1×
“In this setting, damaged nucleotides are excised from DNA upon incision on both sides of the lesion, followed by DNA synthesis to reconstitute genetic integrity (Gillet and Scharer, 2006).”
Timerbaev, A. R., Hartinger, C. G., Aleksenko, S. S., & Keppler, B. K. (2006) · Chemical Reviews · doi:10.1021/cr040704h · Cited by 615
Cisplatin: From DNA damage to cancer chemotherapy
Cohen, S. M., & Lippard, S. J. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)67026-0 · Cited by 614
Shirota, Y., Stoehlmacher, J., Brabender, J., Xiong, Y.-P., Uetake, H., Danenberg, K. D., Groshen, S. G., Tsao-Wei, D. D., Danenberg, P. V., & Lenz, H. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.23.4298 · Cited by 611
Overexpression of Metallothionein Confers Resistance to Anticancer Drugs
Kelley, S. L., Basu, A., Teicher, B. A., Hacker, M. P., Hamer, D. H., & Lazo, J. S. (1988) · Science · doi:10.1126/science.3175622 · Cited by 601
Is Cisplatin-Induced Cell Death Always Produced by Apoptosis?
González, V. M., Fuertes, M. A., Alonso‐Moreno, C., & Pérez, J. M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.657 · Cited by 579
Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease
Sijbers, A. M., de Laat, W. L., Ariza, R. R., Biggerstaff, M., Wei, Y.-F., Moggs, J. G., Carter, K. C., Shell, B. K., Evans, E. L., de Jong, M. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80155-5 · Cited by 546
Eastman, A. R. (1987) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(87)90009-x · Cited by 542
Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling
Mandic, A., Hansson, J., Linder, S. T., & Shoshan, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210284200 · Cited by 507
Metzger, R., Leichman, C. G., Danenberg, K. D., Danenberg, P. V., Lenz, H.-J., Hayashi, K., Groshen, S. G., Salonga, D. S., Cohen, H., Laine, L., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.1.309 · Cited by 505
Loss of DNA mismatch repair in acquired resistance to cisplatin.
Aebi, S. P., Kurdi-Haidar, B., Gordon, R. T., Cenni, B., Zheng, H., Fink, D. A., Christen, R. D., Boland, C. R., Koi, M., Fishel, R. A., et al. (1996) · PubMed · Cited by 502
Niedernhofer, L. J., Odijk, H., Budzowska, M., van Drunen, E., Maas, A., Theil, A. F., de Wit, J., Jaspers, N. G. J., Beverloo, H. B., Hoeijmakers, J. H. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5776-5787.2004 · Cited by 493
The role of DNA mismatch repair in drug resistance
Nebel, S. (1998) · ETH Zürich Research Collection · doi:10.3929/ethz-a-001915508 · Cited by 461
Martins, I., Kepp, O., Schlemmer, F., Adjemian, S., Tailler, M., Shen, S., Michaud, M., Menger, L., Gdoura, A., Tajeddine, N., et al. (2010) · Oncogene · doi:10.1038/onc.2010.500 · Cited by 443
Self-citationThe role of DNA mismatch repair in drug resistance.
Fink, D. A., Aebi, S. P., & Howell, S. B. (1998) · PubMed · Cited by 410
Cisplatin (cis-diamminedichloroplatinum II)
Prestayko, A. W., D'Aoust, J. C., Issell, B. F., & Crooke, S. T. (1979) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(79)80057-2 · Cited by 405
Survivin: A new target for anti-cancer therapy
Ryan, B. M., O’Donovan, N., & Duffy, M. J. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.05.003 · Cited by 378
Mansouri, A., Ridgway, L. D., Korapati, A. L., Zhang, Q. C., Tian, L., Wang, Y., Siddik, Z. H., Mills, G. B., & Claret, F. X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208134200 · Cited by 377
Medical Treatment of Advanced Testicular Cancer
Feldman, D. R. (2008) · JAMA · doi:10.1001/jama.299.6.672 · Cited by 374
Clinical Perspectives on Platinum Resistance
Giaccone, G. (2000) · Drugs · doi:10.2165/00003495-200059004-00002 · Cited by 364
Cisplatin resistance: Preclinical findings and clinical implications
Köberle, B., Tomicic, M. T., Usanova, S., & Kaina, B. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.07.004 · Cited by 361
Samimi, G., Safaei, R., Katano, K., Holzer, A. K., Rochdi, M., Tomioka, M., Goodman, M., & Howell, S. B. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0137 · Cited by 357
Furuta, T., Ueda, T., Aune, G. J., Sarasin, A. R., Kraemer, K. H., & Pommier, Y. G. (2002) · PubMed · Cited by 349
Holzer, A. K., Manorek, G., & Howell, S. B. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022624 · Cited by 323
Chetrit, A., Hirsh‐Yechezkel, G., Ben‐David, Y., Lubin, F., Friedman, E., & Sadetzki, S. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.6905 · Cited by 323
Joaquim Bellmunt, B., Paz-Ares, L. G., Cuello, M., Cecere, F. L., Albiol, S., Guillém, V., Gallardo, E., Carles, J., Méndez, P., de la Cruz, J. J., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdl435 · Cited by 319
Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket
Donnelly, A. C., & Blagg, B. S. J. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708786242895 · Cited by 316
ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair
Ahmad, A., Robinson, A. R., Duensing, A. U., van Drunen, E., Beverloo, H. B., Weisberg, D. B., Hasty, P., Hoeijmakers, J. H. J., & Niedernhofer, L. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00293-08 · Cited by 315
ATR-Chk2 Signaling in p53 Activation and DNA Damage Response during Cisplatin-induced Apoptosis
Pabla, N., Huang, S., Mi, Q.-S., Daniel, R., & Dong, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707568200 · Cited by 309
ERCC1 and ERCC2 Expression in Malignant Tissues From Ovarian Cancer Patients
Dabholkar, M., Bostick-Bruton, F., Weber, C., Bohr, V. A., Egwuagu, C. E., & Reed, E. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.19.1512 · Cited by 305
Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy
Kepp, O., Galluzzi, L., Martins, I., Schlemmer, F., Adjemian, S., Michaud, M., Sukkurwala, A. Q., Menger, L., Zitvogel, L., & Kroemer, G. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9273-4 · Cited by 303
Self-citationTumor-suppressor p53: implications for tumor development and prognosis.
Kirsch, D. G., & Kastan, M. B. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.9.3158 · Cited by 299
Drummond, J. T., Anthoney, A., Brown, R. E., & Modrich, P. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19645 · Cited by 295
Vaisman, A., Varchenko, M., Umar, A., Kunkel, T. A., Risinger, J. I., Barrett, J. C., Hamilton, T. C., & Chaney, S. G. (1998) · PubMed · Cited by 294
Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin
Persons, D. L., Yazlovitskaya, E. M., & Pelling, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004267200 · Cited by 293
Bellon, S. F., Coleman, J. H., & Lippard, S. J. (1991) · Biochemistry · doi:10.1021/bi00246a021 · Cited by 293
Katano, K., Kondo, A., Safaei, R., Holzer, A. K., Samimi, G., Mishima, M., Kuo, Y., Rochdi, M., & Howell, S. B. (2002) · PubMed · Cited by 290
Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator
Ishida, S., McCormick, F. P., Smith‐McCune, K., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.011 · Cited by 290
Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology
Ratnam, K., & Low, J. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2260 · Cited by 290
Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology
Shuck, S. C., Short, E. A., & Turchi, J. J. (2008) · Cell Research · doi:10.1038/cr.2008.2 · Cited by 289
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Shachar, S., Ziv, O., Avkin, S., Adar, S., Wittschieben, J., Reißner, T., Chaney, S., Friedberg, E. C., Wang, Z., Carell, T., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.281 · Cited by 284
Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer Chemotherapy
Chen, H. H. W., & Kuo, M. T. (2010) · Metal-Based Drugs · doi:10.1155/2010/430939 · Cited by 284
Preclinical Perspectives on Platinum Resistance
Kèlland, L. R. (2000) · Drugs · doi:10.2165/00003495-200059004-00001 · Cited by 280
DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response
Chaney, S. G., & Sancar, A. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.19.1346 · Cited by 279
Yang, Z., Schumaker, L. M., Egorin, M. J., Zuhowski, E. G., Guo, Z., & Cullen, K. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1037 · Cited by 270
Gifford, G., Paul, J., Vasey, P. A., Kaye, S. B., & Brown, R. E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0732 · Cited by 262
Preclinical studies identifying carboplatin as a viable cisplatin alternative
Harrap, K. R. (1985) · Cancer Treatment Reviews · doi:10.1016/0305-7372(85)90015-5 · Cited by 259
Adriamycin cardiomyopathy—risk factors
Minow, R. A., Benjamin, R. S., Lee, E. T., & Gottlieb, J. A. (1977) · Cancer · doi:10.1002/1097-0142(197704)39:4 · Cited by 252
Koike, K., Kawabe, T., Tanaka, T., Toh, S., Uchiumi, T., Wada, M., Akiyama, S. I., Ono, M., & Kuwano, M. (1997) · PubMed · Cited by 249
Brown, R. E., Hirst, G. L., Gallagher, W. M., McIlwrath, A. J., Margison, G. P., van der Zee, A. G., & Anthoney, A. (1997) · Oncogene · doi:10.1038/sj.onc.1201167 · Cited by 243
Antitumor activity of 1,2-diaminocyclohexaneplatinum complexes against Sarcoma-180 ascites form
Kidani, Y., Kenji Inagaki, Z., Iigo, M., Hoshi, A., & Kuretani, K. (1978) · Journal of Medicinal Chemistry · doi:10.1021/jm00210a029 · Cited by 239
Division, P. (1992) · Lung Cancer · doi:10.1016/0169-5002(92)90185-m · Cited by 238
Apoptosis regulation in tetraploid cancer cells
Castedo, M., Coquelle, A., Vivet, S., Vitale, I., Kauffmann, A., Dessen, P., Péquignot, M. O., Casares, N., Valent, A., Mouhamad, S., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601127 · Cited by 224
Self-citationEffect of BRCA mutations on the length of survival in epithelial ovarian tumors.
David, Y. B., Chetrit, A., Hirsh-Yechezkel, G., Friedman, E., Beck, B. D., Beller, U., Ben-Baruch, G., Fishman, A., Levavi, H., Lubin, F., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.2.463 · Cited by 224
Kèlland, L. R., Abel, G., McKeage, M. J., Jones, M., Goddard, P. M., Valenti, M., Murrer, B. A., & Harrap, K. R. (1993) · PubMed · Cited by 224
Recent Developments in the Field of Anticancer Platinum Complexes
Galanski, M. S. (2006) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489206777442287 · Cited by 223
Lewis, A. D., Hayes, J. D., & Wolf, C. R. (1988) · Carcinogenesis · doi:10.1093/carcin/9.7.1283 · Cited by 223
Berndtsson, M., Hägg, M., Panaretakis, T., Havelka, A. M., Shoshan, M. C., & Linder, S. T. (2006) · International Journal of Cancer · doi:10.1002/ijc.22132 · Cited by 221
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
Tajeddine, N., Galluzzi, L., Kepp, O., Hangen, E., Morselli, E., Senovilla, L., Araujo, N., Pinna, G., Larochette, N., Zamzami, N., et al. (2008) · Oncogene · doi:10.1038/onc.2008.63 · Cited by 217
Self-citationActivation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance
Brozović, A., & Osmak, M. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.10.007 · Cited by 204
Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase η
Alt, A., Lammens, K., Chiocchini, C., Lammens, A., Pieck, J. C., Kuch, D., Hopfner, K., & Carell, T. (2007) · Science · doi:10.1126/science.1148242 · Cited by 204
The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin
Mello, J. A., Acharya, S., Fishel, R. A., & Essigmann, J. M. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90149-0 · Cited by 198
Zhen, W. K., Link, C. J., O'Connor, P. M., Reed, E., Parker, R., Howell, S. B., & Bohr, V. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.3689 · Cited by 196
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis
Slater, A. F. G., Nobel, S., Maellaro, E., Bustamante, J., Kimland, M., & Orrenius, S. (1995) · Biochemical Journal · doi:10.1042/bj3060771 · Cited by 188
Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity
More, S. S., Akil, O., Ianculescu, A. G., Geier, E. G., Lustig, L. R., & Giacomini, K. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-10.2010 · Cited by 177
Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease
Williams, J. A. S., Lucas, P. C., Griffith, K. A., Choi, M., Fogoros, S. K., Hu, Y., & Liu, J. R. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.10.026 · Cited by 173
Loh, S. Y., Mistry, P., Kèlland, L. R., Abel, G., & Harrap, K. R. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.419 · Cited by 167
Usanova, S., Piée‐Staffa, A., Sied, U., Thomale, J., Schneider, A., Kaina, B., & Köberle, B. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-248 · Cited by 164
Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review
Stordal, B., Pavlakis, N., & Davey, R. (2007) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2007.01.009 · Cited by 163
Li, Q., Yu, J., Mu, C., Yunmbam, M. K., Slavsky, D., Cross, C. L., Bostick-Bruton, F., & Reed, E. (2000) · PubMed · Cited by 161
Niedernhofer, L. J., Essers, J., Weeda, G., Beverloo, B., de Wit, J., Muijtjens, M., Odijk, H., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6540 · Cited by 159
Mutations of the p53 gene do not occur in testis cancer.
Peng, H., Hogg, D., Malkin, D. M., Bailey, D., Gallie, B. L., Bulbul, M., Jewett, M. A. S., Buchanan, J., & Goss, P. E. (1993) · PubMed · Cited by 154
Altered ErbB Receptor Signaling and Gene Expression in Cisplatin-Resistant Ovarian Cancer
MacLeod, K. G., Mullen, P., Sewell, J. M., Rabiasz, G. J., Lawrie, S. S., Miller, E. P., Smyth, J. F., & Langdon, S. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2684 · Cited by 152
Jun, H. J., Ahn, M., Kim, H. S., Yi, S. Y., Han, J., Lee, S. K., Ahn, Y. C., Jeong, H.-S., Son, Y.-I., Baek, J.-H., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604464 · Cited by 149
Michaud, W. A., Nichols, A. C., Mroz, E. A., Faquin, W. C., Clark, J. R., Begum, S., Westra, W. H., Wada, H., Busse, P. M., Ellisen, L. W., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2581 · Cited by 147
Brozović, A., Fritz, G., Christmann, M., Zisowsky, J., Jaehde, U., Osmak, M., & Kaina, B. (2004) · International Journal of Cancer · doi:10.1002/ijc.20522 · Cited by 146
Nakayama, K., Kanzaki, A., Ogawa, K., Miyazaki, K., Neamati, N., & Takebayashi, Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10608 · Cited by 145
Altered expression and mutation of β‐catenin gene in gastric carcinomas and cell lines
Woo, D. K., Kim, H. S., Lee, H. S., Kang, Y. H., Yang, H. K., & Kim, W. H. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20010320)95:2 · Cited by 143
Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes
Eastman, A. R. (1987) · Chemico-Biological Interactions · doi:10.1016/0009-2797(87)90004-4 · Cited by 141
de La Motte Rouge, T., Galluzzi, L., Olaussen, K. A., Zermati, Y., Tasdemir, E., Robert, T., Ripoche, H., Lazar, V., Dessen, P., Harper, F., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0538 · Cited by 141
Self-citationThe Internalization and Degradation of Human Copper Transporter 1 following Cisplatin Exposure
Holzer, A. K., & Howell, S. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1710 · Cited by 140
Mitsuuchi, Y., Johnson, S. W., Selvakumaran, M., Williams, S. J., Hamilton, T. C., & Testa, J. R. (2000) · PubMed · Cited by 137
Yeh, P.-Y., Chuang, S., Yeh, K., Song, Y., Ea, C.-K., & Cheng, A. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00908-5 · Cited by 136
Handra‐Luca, A., Hernandez, J., Mountzios, G., Clermont, E., Guily, J. L. S., Soria, J., & Fouret, P. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0252 · Cited by 135
Loss of DNA Polymerase ζ Causes Chromosomal Instability in Mammalian Cells
Wittschieben, J. P., Reshmi, S. C., Gollin, S. M., & Wood, R. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2982 · Cited by 131
Yamasaki, M., Makino, T., Masuzawa, T., Kurokawa, Y., Miyata, H., Takiguchi, S., Nakajima, K., Fujiwara, Y., Matsuura, N., Mori, M., et al. (2011) · British Journal of Cancer · doi:10.1038/sj.bjc.6606071 · Cited by 130
Yu, H., Su, J., Xu, Y., Kang, J., Li, H., Zhang, L., Yi, H., Xiang, X., Liu, F., & Sun, L. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.01.019 · Cited by 130
Liedert, B., Materna, V., Schadendorf, D., Thomale, J., & Lage, H. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12313.x · Cited by 129
Branch, P., Masson, M., Aquilina, G., Bignami, M., & Karran, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203668 · Cited by 126
Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors
David, Y. B., Chetrit, A., Hirsh‐Yechezkel, G., Friedman, E., Beck, B. D., Beller, U., Ben‐Baruch, G., Fishman, A., Levavi, H., Lubin, F., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.2.463 · Cited by 126
Reversal of Multidrug Resistance by Natural Substances from Plants
Wang, Q., Michalak, K., Wesołowska, O., Deli, J., Molnár, P., Hohmann, J., Molnar, J. A., & Engi, H. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610792928103 · Cited by 124
Coquerelle, T. M., Dösch, J., & Kaina, B. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00035-5 · Cited by 123
Ren, J., He, W., Nong, L., Zhu, Q., Hu, K., Zhang, R., Huang, L., Zhu, F., & Wu, G. (2010) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2009.0701 · Cited by 123
Cisplatin Induction of ERCC-1 mRNA Expression in A2780/CP70 Human Ovarian Cancer Cells
Li, Q., Gardner, K. L., Zhang, L., Tsang, B., Bostick-Bruton, F., & Reed, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23419 · Cited by 120
The role of copper transporters in the development of resistance to Pt drugs
Safaei, R., Holzer, A. K., Katano, K., Samimi, G., & Howell, S. B. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.05.006 · Cited by 114
Nakayama, K., Kanzaki, A., Terada, K., Mutoh, M., Ogawa, K., Sugiyama, T., Takenoshita, S., Itoh, K., Yaegashi, N., Miyazaki, K., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0454 · Cited by 114
Mellish, K. J., Kelland, L., & Harrap, K. R. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.322 · Cited by 113
Sakamoto, M., Kondo, A., Kawasaki, K., Goto, T., Sakamoto, H., Miyake, K., Koyamatsu, Y., Akiya, T., Iwabuchi, H., Muroya, T., et al. (2001) · PubMed · Cited by 110
Mutagenic and carcinogenic properties of platinum-based anticancer drugs
Sanderson, B. J. S., Ferguson, L. R., & Denny, W. A. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(96)00022-x · Cited by 109
Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer
Hengstler, J. G., Lange, J., Kett, A., Dornhöfer, N., Meinert, R., Arand, M., Knapstein, P. G., Becker, R., Oesch, F., & Tanner, B. (1999) · PubMed · doi:10.5167/uzh-113865 · Cited by 106
Ren, A., Yan, G., You, B., & Sun, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6248 · Cited by 106
MutS Homologue 2 and the Long-term Benefit of Adjuvant Chemotherapy in Lung Cancer
for the International Adjuvant Lung Trial-Bio investigators, Kamal, N. S., Soria, J., Mendiboure, J., Planchard, D., Olaussen, K. A., Rousseau, V., Popper, H., Pirker, R., Bertrand, P., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2204 · Cited by 103
Baekelandt, M. M. O., Holm, R., Nesland, J. M., Trope, C. G., & Kristensen, G. B. (2000) · PubMed · Cited by 102
Wakai (2010) · Oncology Reports · doi:10.3892/or_00000721 · Cited by 99
Ceppi, P., Novello, S., Cambieri, A., Longo, M., Monica, V., Iacono, M. L., Levra, M. G., Saviozzi, S., Volante, M., Papotti, M. G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1227 · Cited by 98
Cisplatinum and Taxol Induce Different Patterns of p53 Phosphorylation
Damia, G. L. M., Filiberti, L., Vikhanskaya, F., Carrassa, L., Taya, Y., D’Incalci, M., & Broggini, M. (2001) · Neoplasia · doi:10.1038/sj.neo.7900122 · Cited by 96
Deng, X., Ewton, D. Z., & Friedman, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2903 · Cited by 92
Phase II Study of Picoplatin As Second-Line Therapy for Patients With Small-Cell Lung Cancer
Eckardt, J. R., Bentsion, D., Lipatov, O. N., Polyakov, I. S., MacKintosh, F. R., Karlin, D. A., Baker, G. S., & Breitz, H. B. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.3235 · Cited by 92
Gourley, C., Michie, C. O., Roxburgh, P., Yap, T. A., Harden, S., Paul, J., Ragupathy, K., Todd, R., Petty, R., Reed, N., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.1082 · Cited by 88
Dent, P., & Grant, S. (2001) · PubMed · Cited by 88
Satraplatin: an orally available platinum analog for the treatment of cancer
Choy, H. (2006) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.6.7.973 · Cited by 85
El-Khateeb, M., Appleton, T. G., Gahan, L. R., Charles, B. G., Berners‐Price, S. J., & Bolton, A.-M. (1999) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00146-4 · Cited by 84
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Pinti, M., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3504 · Cited by 83
Self-citationYamamoto, K., Okamoto, A., Isonishi, S., Ochiai, K., & Ohtake, Y. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00532-8 · Cited by 81
Jin, J., Wang, F., Wei, H., & Liu, G.-T. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-004-0868-0 · Cited by 80
Platinum speciation used for elucidating activation or inhibition of Pt-containing anti-cancer drugs
Michalke, B. (2010) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2010.01.006 · Cited by 78
Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway
Vitale, I., Galluzzi, L., Vivet, S., Nanty, L., Dessen, P., Senovilla, L., Olaussen, K. A., Lazar, V., Prudhomme, M., Golsteyn, R. M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001337 · Cited by 77
Self-citationFriedman, E. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21451 · Cited by 77
Wang, Y., Nangia‐Makker, P., Balan, V., Hogan, V. A., & Raz, A. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.79 · Cited by 77
Gadducci, A., Cosio, S., Muraca, S., & Genazzani, A. R. (2002) · PubMed · Cited by 75
Wang, H., Zhang, S., Wang, S., Lü, J., Wu, W., Weng, L., Chen, D., Zhang, Y., Lu, Z., Yang, H. J., et al. (2009) · Neuro-Oncology · doi:10.1215/15228517-2009-015 · Cited by 74
Serrano, F. A., Matsuo, A. L., Monteforte, P. T., Bechara, A. H. S., Smaili, S. S., Santana, D. P., Rodrigues, T., Pereira, F. V., Silva, L. S., Machado, J., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-296 · Cited by 74
Aida, T., Takebayashi, Y., Shimizu, T., Okamura, C., Higasimoto, M., Kanzaki, A., Nakayama, K., Terada, K., Sugiyama, T., Miyazaki, K., et al. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.12.042 · Cited by 68
Spierings, D. C. J., de Vries, E. G. E., Vellenga, E., & de Jong, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401248 · Cited by 67
Ovarian cancer: new clinical approaches
Ozols, R. F. (1991) · Cancer Treatment Reviews · doi:10.1016/0305-7372(91)90027-w · Cited by 66
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells
Gao, J., Zheng, Z., Rawal, B., Schell, M. J., Bepler, G., & Haura, E. B. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.17.9322 · Cited by 65
DNA Damage Recognition and Nucleotide Excision Repair in Mammalian CellsPreprint
Wood, R. D., Araújo, S. J., Ariza, R. R., Batty, D. P., Biggerstaff, M., Evans, E. L., Gaillard, P.-H. L., Gunz, D., Köberle, B., Kuraoka, I., et al. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.173 · Cited by 65
Survivin as a predictor of cis‐diamminedichloroplatinum sensitivity in gastric cancer patients
Nakamura, M., Tsuji, N., Asanuma, K., Kobayashi, D., Yagihashi, A., Hirata, K., Torigoe, T., Sato, N., & Watanabe, N. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03169.x · Cited by 63
Zhang, Y., & Shen, X. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2090 · Cited by 60
Wang, J., Pabla, N., Wang, C., Wang, W., Schoenlein, P. V., & Dong, Z. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00509.2005 · Cited by 53
Shen, D., Ma, J., Okabe, M., Zhang, G., Xia, D., & Gottesman, M. M. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22287 · Cited by 52
The Translesion Polymerase Rev3L in the Tolerance of Alkylating Anticancer Drugs
Roos, W. P., Tsaalbi‐Shtylik, A., Tsaryk, R., Güvercin, F., de Wind, N., & Kaina, B. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058131 · Cited by 52
c-Abl phosphorylation of ΔNp63α is critical for cell viability
Yuan, M., Luong, P., Hudson, C., Gudmundsdottir, K. K., & Basu, S. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.15 · Cited by 52
Bramson, J. L., & Panasci, L. (1993) · PubMed · Cited by 51
Smith, C. D., Carmeli, S., MOORE, R. E., & Patterson, G. M. L. (1993) · PubMed · Cited by 50
Plenchette, S., Cheung, H. H., Fong, W. G., LaCasse, E. C., & Korneluk, R. G. (2007) · PubMed · Cited by 50
Han, J., Hong, E. K., Choi, B. G., Park, J. N., Kim, K. W., Kang, J., Jin, J., Park, S. Y., Hong, Y. S., & Lee, K. S. (2003) · Medical Oncology · doi:10.1385/mo:20:4:355 · Cited by 49
Kim, M. K., Cho, K.-J., Kwon, G. Y., Park, S.-I., Kim, Y., Kim, J. H., Song, H.-Y., Shin, J. H., Jung, H., Lee, G. H., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4848 · Cited by 48
Bassett, E., Vaisman, A., Leeman, K. T., McCall, C. M., Masutani, C., Hanaoka, F., & Chaney, S. G. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00150-7 · Cited by 45
Oxaliplatin in First-line Therapy for Advanced Non–Small-Cell Lung Cancer
Raez, L. E., Kobina, S., & Santos, E. S. (2010) · Clinical Lung Cancer · doi:10.3816/clc.2010.n.003 · Cited by 42
Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells
Hu, J., & Friedman, E. (2010) · Genes & Cancer · doi:10.1177/1947601910377644 · Cited by 42
Changes in survivin messenger RNA level during cisplatin treatment in gastric cancer
Ikeguchi, M., & Kaibara, N. (2001) · International Journal of Molecular Medicine · doi:10.3892/ijmm.8.6.661 · Cited by 41
Jain, H. V., & Meyer‐Hermann, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-3174 · Cited by 41
Erović, B. M., Pelzmann, M., Grasl, M. C., Johannes, P., Kornek, G. V., Brannath, W., Selzer, E., & Thurnher, D. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1170 · Cited by 39
Biggerstaff, M., & Wood, R. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50510-5 · Cited by 36
Miyazaki, T., Kato, H., Faried, A., Sohda, M., Nakajima, M., Fukai, Y., Masuda, N., Manda, R., Fukuchi, M., Ojima, H., et al. (2005) · PubMed · Cited by 35
Kelman, A. D., & Peresie, H. J. (1980) · PubMed · Cited by 35
Janson, V., Johansson, A. F., & Grankvist, K. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.54 · Cited by 34
Fijołek, J., Wiatr, E., Rowinska-Zakrzewska, E., Giedronowicz, D., Langfort, R., Chabowski, M., Orlowski, T. M., & Roszkowski, K. (2006) · The International Journal of Biological Markers · doi:10.1177/172460080602100203 · Cited by 33
Karczmarek-Borowska, B., Filip, A. A., Wojcierowski, J., Smoleń, A., Pilecka, I., & Jabłonka, A. (2005) · PubMed · doi:10.5603/4604 · Cited by 32
Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors
Gaur, S., Chen, L., Yang, L., Wu, X., Un, F., & Yen, Y. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.06.005 · Cited by 31
Yoshida, M., Khokhar, A. R., & Siddik, Z. H. (1994) · PubMed · Cited by 26
Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells
Wada, H., Saikawa, Y., Niida, Y., Nishimura, R., Noguchi, T., Matsukawa, H., Ichihara, T., & Koizumi, S. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00027-7 · Cited by 25
de Pinho, M. B., Costas, F., de Séllos, J., Dienstmann, R., Andrade, P. B., Herchenhorn, D., Peixoto, F. A., Santos, V. O., Small, I. A., Guimarães, D. P., et al. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.03.016 · Cited by 18
Olaussen, K. A. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.20.9785 · Cited by 11
Research works printed but not linked: 1
- Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T et al. (2001). Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy. Int J Cancer 95: 92–95. · DOI
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Metadata
- Authors
- Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Université Paris-Sud (FR)
- Corresponding author
- Kroemer, G
- Venue
- Oncogene
- Published
- 2011-09-05
- Volume
- 31
- Issue
- 15
- Pages
- 1869-1883
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2141037581
- Cited by
- 2,760
- References
- 196
- Citations by year
- 2026: 154 · 2025: 187 · 2024: 244 · 2023: 220 · 2022: 247 · 2021: 308 · 2020: 252 · 2019: 213 · 2018: 169 · 2017: 167 · 2016: 159 · 2015: 160 · 2014: 145 · 2013: 89 · 2012: 44
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Ligue Contre le Cancer
- Fondation Bettencourt Schueller
- Labex Immuno-Oncology
- Topics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
- Keywords
- cisplatin resistance, chemoresistance, platinum anticancer drugs, DNA damage response, mitochondrial apoptosis, chemosensitization, DNA lesions
- MeSH terms
- Cisplatin, DNA Damage, DNA Repair, Humans, Signal Transduction, DNA Adducts, Drug Resistance, Neoplasm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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