Mitotic catastrophe: a mechanism for avoiding genomic instability

Microtubules as a target for anticancer drugs

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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p53 in health and disease

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The spindle-assembly checkpoint in space and time

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Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

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Autophagic cell death: the story of a misnomer

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Cell death by mitotic catastrophe: a molecular definition

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IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

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Microtubules and resistance to tubulin-binding agents

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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

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Survivin, cancer networks and pathway-directed drug discovery

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

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Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

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DNA damage checkpoints: from initiation to recovery or adaptation

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

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Death through a tragedy: mitotic catastrophe

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Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

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Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesPreprint

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Stuck in Division or Passing through

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Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice

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Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

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Does aneuploidy cause cancer?

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Cell death assays for drug discovery

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Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint

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Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

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Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

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Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death

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Examining the link between chromosomal instability and aneuploidy in human cells

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

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Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

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Animal Cytokinesis: From Parts List to Mechanisms

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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

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p53 regulates a G 2 checkpoint through cyclin B1

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Spindle Multipolarity Is Prevented by Centrosomal Clustering

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Survivin: A new target for anti-cancer therapy

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The consequences of tetraploidy and aneuploidy

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Phosphorylation of Mcl‐1 by CDK1–cyclin B1 initiates its Cdc20‐dependent destruction during mitotic arrest

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Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype

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G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

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Polo-like Kinase 1 (Plk1) Inhibits p53 Function by Physical Interaction and Phosphorylation

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Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis

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Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

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Cyclin-Dependent Kinase 1-Mediated Bcl-x L /Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

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Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.

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Kinesin motor proteins as targets for cancer therapy

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Apoptosis regulation in tetraploid cancer cells

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Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

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Radiation-induced DNA damage and delayed induced genomic instability

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Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

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A tumor suppressor function for caspase-2

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Illicit survival of cancer cells during polyploidization and depolyploidization

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Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

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DNA damage induces two distinct modes of cell death in ovarian carcinomas

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Mitotic Catastrophe Results in Cell Death by Caspase-Dependentand Caspase-Independent Mechanisms

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Depletion of Chk1 Leads to Premature Activation of Cdc2-cyclin B and Mitotic Catastrophe

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The enigma of caspase-2: the laymen's view

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Phosphorylation of Bcl-2 in G2/M Phase-arrested Cells following Photodynamic Therapy with Hypericin Involves a CDK1-mediated Signal and Delays the Onset of Apoptosis

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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

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Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase‐2

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Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells

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Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint Abrogation

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Caspase-2 deficiency enhances aging-related traits in mice

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Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression

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Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

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Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

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Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

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Reappraisal of the Hansemann–Boveri hypothesis on the origin of tumors

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An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner

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Preventing aneuploidy: The contribution of mitotic checkpoint proteins

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The role of Aurora-A inhibitors in cancer therapy

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Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint

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TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

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A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

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Stochastic Competition between Mechanistically Independent Slippage and Death Pathways Determines Cell Fate during Mitotic Arrest

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Anaphase Catastrophe Is a Target for Cancer Therapy

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Caspase-Mediated Specific Cleavage of BubR1 Is a Determinant of Mitotic Progression

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Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

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HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells

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Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5

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Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

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Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

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p53 represses the polyploidization of primary mammary epithelial cells by activating apoptosis

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An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe

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Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function

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Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway

Sekhar, K. R., Sonar, V. N., Muthusamy, V., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3212 · Cited by 36 · see citing works

p31comet Induces Cellular Senescence through p21 Accumulation and Mad2 Disruption

Yun, M., Han, Y.-H., Yoon, S. H., Kim, H. Y., Kim, B., Ju, Y.-J., Kang, C., Jang, S. H., Chung, H. Y., Lee, S., et al. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0056 · Cited by 25 · see citing works

Effect of lidamycin on telomerase activity in human hepatoma BEL-7402 cells.

Gao, R., Liang, Y.-X., Li, D.-D., Zhang, H., & Zhen, Y. (2007) · PubMed · Cited by 11 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Molecular mechanisms of cisplatin resistance

Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G. (2012) · Oncogene · doi:10.1038/onc.2011.384 · Cited by 2,760 · see citing works

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421 · see citing works

Self-consumption: the interplay of autophagy and apoptosis

Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172 · see citing works

Systems biology of cisplatin resistance: past, present and future

Galluzzi, L., Vitale, I., Michels, J., Brenner, C., Szabadkai, G., Harel-Bellan, A., Castedo, M., & Kroemer, G. (2014) · Cell Death & Disease · doi:10.1038/cddis.2013.428 · Cited by 782 · see citing works

Mitochondria: master regulators of danger signalling

Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733 · see citing works

Inflammasomes in carcinogenesis and anticancer immune responses

Zitvogel, L., Kepp, O., Galluzzi, L., & Kroemer, G. (2012) · Nature Immunology · doi:10.1038/ni.2224 · Cited by 593 · see citing works

Targeting Mitosis in Cancer: Emerging Strategies

Dominguez-Brauer, C., Thu, K. L., Mason, J. M., Blaser, H., Bray, M. R., & Mak, T. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.006 · Cited by 495 · see citing works

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., et al. (2012) · Science · doi:10.1126/science.1224922 · Cited by 436 · see citing works

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

Rodriguez-Ruiz, M. E., Vitale, I., Harrington, K. J., Melero, I., & Galluzzi, L. (2020) · Nature Immunology · doi:10.1038/s41590-019-0561-4 · Cited by 385 · see citing works

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

Yamazaki, T., Kirchmair, A., Sato, A., Buqué, A., Rybstein, M., Petroni, G., Bloy, N., Finotello, F., Stafford, L., Navarro Manzano, E., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0751-0 · Cited by 359 · see citing works

Various modes of cell death induced by DNA damage

Surova, O., & Zhivotovsky, B. (2013) · Oncogene · doi:10.1038/onc.2012.556 · Cited by 334 · see citing works

Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells

Giladi, M., Schneiderman, R. S., Voloshin, T., Porat, Y., Munster, M., Blat, R., Sherbo, S., Bomzon, Z., Urman, N., Itzhaki, A., et al. (2015) · Scientific Reports · doi:10.1038/srep18046 · Cited by 327 · see citing works

Telomere-driven diseases and telomere-targeting therapies

Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257 · see citing works

Organelle-specific initiation of cell death

Galluzzi, L., Bravo-San Pedro, J. M., & Kroemer, G. (2014) · Nature Cell Biology · doi:10.1038/ncb3005 · Cited by 239 · see citing works

Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit

Gera, N., Yang, A., Holtzman, T. S., Lee, S. X., Wong, E. T., & Swanson, K. D. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125269 · Cited by 217 · see citing works

Organelle-Specific Initiation of Autophagy

Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205 · see citing works

Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury

Sancho-Martínez, S. M., López-Novoa, J. M., & López-Hernández, F. J. (2015) · Clinical Kidney Journal · doi:10.1093/ckj/sfv069 · Cited by 130 · see citing works

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

Denisenko, T. V., Sorokina, I. V., Gogvadze, V., & Zhivotovsky, B. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2015.11.002 · Cited by 108 · see citing works

A three-state model of telomere control over human proliferative boundaries

Cesare, A. J., & Karlseder, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.007 · Cited by 106 · see citing works

Caspase-2-mediated cell death is required for deleting aneuploid cells

Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L., & Kumar, S. (2017) · Oncogene · doi:10.1038/onc.2016.423 · Cited by 66 · see citing works

CDKN2A inhibits formation of homotypic cell-in-cell structures

Liang, J., Fan, J., Wang, M., Niu, Z., Zhang, Z., Yuan, L., Tai, Y., Chen, Z., Song, S., Wang, X., et al. (2018) · Oncogenesis · doi:10.1038/s41389-018-0056-4 · Cited by 49 · see citing works

Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

Patyka, M., Sharifi, Z., Petrecca, K., Mansure, J., Jean-Claude, B., & Sabri, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11197 · Cited by 42 · see citing works

Karyotypic Aberrations in Oncogenesis and Cancer Therapy

Vitale, I., Manic, G., Senovilla, L., Kroemer, G., & Galluzzi, L. (2015) · Trends in Cancer · doi:10.1016/j.trecan.2015.08.001 · Cited by 34 · see citing works

Essential role for the <scp>TRF</scp>2 telomere protein in adult skin homeostasis

Martínez, P., Ferrara‐Romeo, I., Flores, J. M., & Blasco, M. A. (2014) · Aging Cell · doi:10.1111/acel.12221 · Cited by 26 · see citing works

N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore–microtubule dynamics

Orticello, M., Fiore, M., Totta, P., Desideri, M., Barisic, M., Passeri, D., Lenzi, J., Rosa, A., Orlandi, A., Maiato, H., et al. (2015) · Oncogene · doi:10.1038/onc.2014.265 · Cited by 12 · see citing works

Mitotic Catastrophe

Chow, J. P. H., & Poon, R. Y. C. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1770-6_5 · Cited by 4 · see citing works

Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin

Lanz, H. L., Zimmerman, R. M. E., Brouwer, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.2 · Cited by 25 · see citing works

An essential role for p73 in regulating mitotic cell death

Toh, W. H., Nam, S. Y., & Sabapathy, K. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.181 · Cited by 40 · see citing works

Mitotic Arrest and Cell Fate: Why and How Mitotic Inhibition of Transcription Drives Mutually Exclusive Events

Blagosklonny, M. V. (2007) · Cell Cycle · doi:10.4161/cc.6.1.3682 · Cited by 209 · see citing works

Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest

Wang, P., Lindsay, J., Owens, T. W., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.050 · Cited by 39 · see citing works