The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
Open accessAbstract
The peroxisome proliferators-activated receptor (PPAR)γ pathway is involved in cancer, but it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells, miR-27b targets the 3′ untranslated region of PPARγ and inhibits its mRNA and protein expression. miR-27b overexpression or PPARγ inhibition blocks cell growth in vitro and tumor growth in mouse xenografts. PPARγ activates expression of the pH regulator NHE1, which is associated with tumor progression. Lastly, miR-27b through PPARγ regulates nuclear factor-κB activity and transcription of inflammatory target genes. Thus, in neuroblastoma, miR-27b functions as a tumor suppressor by inhibiting the tumor-promoting function of PPARγ, which triggers an increased inflammatory response. In contrast, in breast cancer cells, PPARγ inhibits NHE1 expression and the inflammatory response, and it functions as a tumor suppressor. We suggest that the ability of PPARγ to promote or suppress tumor formation is linked to cell type-specific differences in regulation of NHE1 and other target genes.
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Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374
Self-citationmicroRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
Karbiener, M., Fischer, C., Nowitsch, S., Opriessnig, P., Papak, C., Ailhaud, G., Dani, C., Amri, E.-Z., & Scheideler, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.098 · Cited by 409
Jennewein, C., von Knethen, A., Schmid, T., & Brüne, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.066399 · Cited by 183 · cited 2×
“The miR-27 family (miR-27a and miR-27b) directly targets PPARγ, and it inhibits adipocyte differentiation (Karbiener et al., 2009; Kim et al., 2010) and is induced upon inflammation in macrophages (Jennewein et al., 2010).”
Background
Cited by
DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma
Villanueva, A., Portela, A., Sayols, S., Battiston, C., Hoshida, Y., Méndez‐González, J., Imbeaud, S., Letouzé, E., Hernandez‐Gea, V., Cornella, H., et al. (2015) · Hepatology · doi:10.1002/hep.27732 · Cited by 428
Tong, L., Hao, H., Zhang, Z., Lv, Y., Liang, X., Liu, Q., Liu, T., Gong, P., Zhang, L., Cao, F., et al. (2021) · Theranostics · doi:10.7150/thno.62046 · Cited by 325
MicroRNAs: Roles in Regulating Neuroinflammation
Gaudet, A. D., Fonken, L. K., Watkins, L. R., Nelson, R. J., & Popovich, P. G. (2018) · The Neuroscientist · doi:10.1177/1073858417721150 · Cited by 236
The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Yan, Y., Chen, X., Wang, X., Zhao, Z., Hu, W., Zeng, S., Wei, J., Yang, X., Qian, L., Zhou, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1172-5 · Cited by 113
Metadata
- Authors
- Lee, J.-J., Drakaki, A., Iliopoulos, D., & Struhl, K.
- Venue
- Oncogene
- Published
- 2011-11-28
- Volume
- 31
- Issue
- 33
- Pages
- 3818-3825
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2086564940
- Cited by
- 163
- References
- 4
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
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