Cited by 206Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerMicrotubule and mitosis dynamics

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CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

Tigan, A-S, Bellutti, F, Kollmann, K, Tebb, G, Sexl, V·2016·Oncogene

DOI 10.1038/onc.2015.407

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Abstract

The G1 cell-cycle kinase CDK6 has long been thought of as a redundant homolog of CDK4. Although the two kinases have very similar roles in cell-cycle progression, it has recently become apparent that they differ in tissue-specific functions and contribute differently to tumor development. CDK6 is directly involved in transcription in tumor cells and in hematopoietic stem cells. These functions point to a role of CDK6 in tissue homeostasis and differentiation that is partially independent of CDK6's kinase activity and is not shared with CDK4. We review the literature on the contribution of CDK6 to transcription in an attempt to link the new findings on CDK6's transcriptional activity to cell-cycle progression. Finally, we note that anticancer therapies based on the inhibition of CDK6 kinase activity fail to take into account its kinase-independent role in tumor development.

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Authors: Tigan, A.-S., Bellutti, F., Kollmann, K., Tebb, G., & Sexl, V
Affiliations: University of Veterinary Medicine Vienna (AT)
Corresponding author: Sexl, V
ORCID: Bellutti, F
Kollmann, K
Tebb, G
Sexl, V
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2015-10-26
Volume: 35
Issue: 24
Pages: 3083-3091
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/onc.2015.407
OpenAlex: W1874582198
Cited by: 204
References: 177
Citations by year: 2026: 15 · 2025: 16 · 2024: 22 · 2023: 20 · 2022: 35 · 2021: 17 · 2020: 38 · 2019: 17 · 2018: 11 · 2017: 9 · 2016: 4
FWCI: 0.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: CDK6, CDK4, cell cycle progression, transcriptional regulation, kinase-independent function, hematopoietic stem cells, carcinogenesis, tissue homeostasis, cell differentiation, CDK6 inhibitors, cancer therapy
MeSH terms: Transcriptional Activation, Cyclin-Dependent Kinase 6, Cell Cycle Checkpoints

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CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

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