CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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Cell cycle, CDKs and cancer: a changing paradigm

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p21 is a universal inhibitor of cyclin kinases

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A cell cycle regulator potentially involved in genesis of many tumor types

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Whole genomes redefine the mutational landscape of pancreatic cancer

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CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

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Cdks, cyclins and CKIs: roles beyond cell cycle regulation

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NF‐κB and the link between inflammation and cancer

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To cycle or not to cycle: a critical decision in cancer

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Inflammation meets cancer, with NF-κB as the matchmaker

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New functional activities for the p21 family of CDK inhibitors.

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Mammalian cyclin-dependent kinases

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

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The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

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Inhibition of cyclin-dependent kinases by p21.

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Living with or without cyclins and cyclin-dependent kinases

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Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

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D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

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D-type cyclins

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Minireview: Cyclin D1: Normal and Abnormal Functions

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Rb Interacts with Histone Deacetylase to Repress Transcription

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Rb targets histone H3 methylation and HP1 to promoters

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Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

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Cell cycle kinases as therapeutic targets for cancer

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A family of human cdc2‐related protein kinases.

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The p16INK4a/CDKN2A tumor suppressor and its relatives

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D type G1 cyclins

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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.Preprint

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The diverse and complex roles of NF-κB subunits in cancer

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

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Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

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Physical interaction of the retinoblastoma protein with human D cyclins

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Signatures of mutation and selection in the cancer genome

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

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Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF.

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Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle

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p16 INK4A is a robust in vivo biomarker of cellular aging in human skin

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A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

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Cyclin-dependent kinases regulate the antiproliferative function of Smads

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.Preprint

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Cyclin-dependent kinases: a family portrait

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CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

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Requirement for CDK4 kinase function in breast cancer

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A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

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A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

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Moonlighting proteins: an intriguing mode of multitasking

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Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

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Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

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Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

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Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

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Tailoring to RB: tumour suppressor status and therapeutic response

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The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

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The Requirement for Cyclin D Function in Tumor Maintenance

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CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

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A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

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Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

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Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

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FOXM1, a typical proliferation-associated transcription factor

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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

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Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

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Signaling through cyclin D-dependent kinases

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The meaning of p16ink4aexpression in tumors: Functional significance, clinical associations and future developments

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Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen

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Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment

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CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

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CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

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Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A Mechanism for Phosphorylation-Induced E2F Release

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Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

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Structural basis of inhibition of CDK–cyclin complexes by INK4 inhibitorsPreprint

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