A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR
Open accessAbstract
Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts enhance colony formation of metastatic ovarian cancer cells, and de novo expression of transforming growth factor-alpha (TGF-α) is induced in stromal fibroblasts co-cultured with ovarian cancer cells. We also observed an over-expression of tumor necrosis factor-alpha (TNF-α) in ovarian cancer cells, which is regulated by promoter DNA hypomethylation as well as chromatin remodeling. Interestingly, this ovarian cancer-derived TNF-α induces TGF-α transcription in stromal fibroblasts through nuclear factor-κB (NF-κB). We further show that TGF-α secreted by stromal fibroblasts in turn promotes peritoneal metastasis of ovarian cancer through epidermal growth factor receptor (EGFR) signaling. Finally, we identify a TNFα-TGFα-EGFR interacting loop between tumor and stromal compartments of human omental metastases. Our results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFα-TGFα-EGFR.
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The tumour-promoting immunosuppressive activity of FAP+ fibroblasts is associated with suppression of TNF signalling, yet TNF is also able to drive fibroblast activation in certain contexts.
“However, the situation with tumour necrosis factor (TNF) produced by CAFs is more nuanced; the tumour-promoting immunosuppressive activity of FAP+ fibroblasts is associated with suppression of TNF signalling, yet TNF is also able to drive fibroblast activation in certain contexts16,124,125.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [125]
The Results section (page unavailable) shows that TNF-α from ovarian cancer cells stimulates NF-κB signalling and TGF-α expression in stromal fibroblasts, supporting the point that TNF can activate fibroblasts in a particular context. The paper does not establish that FAP+ fibroblasts suppress TNF signalling or that the TNF in this interaction is produced by CAFs. (LLM, conf=0.88)
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- Authors
- Lau, T.-S., Chan, L. K.-Y., Wong, E. C.-H., Hui, C. W.-C., Sneddon, K., Cheung, T.-H., Yim, S.-F., Lee, J. H.-S., Yeung, C. S.-Y., Chung, T. K.-H., & Kwong, J.
- Affiliations
- Chinese University of Hong Kong (HK)
- Corresponding author
- Kwong, J
- Venue
- Oncogene
- Published
- 2017-02-06
- Volume
- 36
- Issue
- 25
- Pages
- 3576-3587
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC5485181
- OpenAlex
- W2586149603
- Cited by
- 88
- References
- 55
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 15 · 2019: 14 · 2018: 13 · 2017: 5
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oncogene (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Keele Research Repository (Keele University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- ovarian cancer, peritoneal carcinomatosis, tumor-stroma interactions, TNF-α, transforming growth factor-alpha, EGFR signaling, DNA hypomethylation, chromatin remodeling, NF-κB, epigenetics, tumor microenvironment
- MeSH terms
- Adult, Aged, Animals, Cell Communication, Female, Fibroblasts, Humans, Mice, Nude, Middle Aged, Neoplasm Metastasis, Neoplasm Proteins, Neoplasm Transplantation, Ovarian Neoplasms, Peritoneal Neoplasms, Tumor Necrosis Factor-alpha, Transforming Growth Factor alpha, Stromal Cells, Cell Line, Tumor, Mice, Tumor Microenvironment, ErbB Receptors
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