Tumor necrosis factor or tumor promoting factor?

Inflammation and cancer: back to Virchow?

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An endotoxin-induced serum factor that causes necrosis of tumors

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The TNF and TNF Receptor Superfamilies

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Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

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The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

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Etanercept Therapy in Rheumatoid Arthritis

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Efficacy and safety of retreatment with anti–tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease

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THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

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The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.

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Aspirin use and risk of fatal cancer.

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Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

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Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

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Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

Jaiswal, M., LaRusso, N. F., Burgart, L. J., & Gores, G. J. (2000) · PubMed · Cited by 647 · see citing works

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

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Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

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Biology of Cachexia

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Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells

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Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

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Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database

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Phase II Trial of the Antiangiogenic Agent Thalidomide in Patients With Recurrent High-Grade Gliomas

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Nitric oxide synthase activity in human gynecological cancer.

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Isolated limb perfusion with high-dose tumor necrosis factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial.

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Anti-Cytokine Therapy for Rheumatoid Arthritis

Maini, R. N., & Taylor, P. C. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.207 · Cited by 379 · see citing works

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.

Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · PubMed · Cited by 363 · see citing works

[Etanercept for therapy of rheumatoid arthritis].

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IL-18 regulates IL-1 β -dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1

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Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.

Suganuma, M., Okabe, S., Marino, M. W., Sakai, A., Sueoka, E., & Fujiki, H. (1999) · PubMed · Cited by 303 · see citing works

Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice

Knight, B., Yeoh, G. C., Husk, K. L., Ly, T., Abraham, L. J., Yu, C., Rhim, J. A., & Fausto, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1809 · Cited by 299 · see citing works

Untitled work

(1999) · PubMed · Cited by 277 · see citing works

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

Havell, E. A., Fiers, W. C., & North, R. J. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.1067 · Cited by 274 · see citing works

Genetic Polymorphisms in the Tumor Necrosis Factor Locus Influence Non-Hodgkin's Lymphoma Outcome

Warzocha, K., Ribeiro, P., Bienvenu, J., Roy, P., Charlot, C., Rigal, D., Coiffier, B., & Salles, G. (1998) · Blood · doi:10.1182/blood.v91.10.3574 · Cited by 272 · see citing works

On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

Kollias, G. A., Douni, E. K., Kassiotis, G., & Kontoyiannis, D. L. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01315.x · Cited by 263 · see citing works

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL-1α

Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000115)85:2%3c182::aid-ijc6%3e3.0.co;2-m · Cited by 254 · see citing works

Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression.

Naylor, M. S., Stamp, G., Foulkes, W. D., Eccles, D., & Balkwill, F. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116446 · Cited by 252 · see citing works

Clinical applications of TNF-α in cancer

Lejeune, F. J., Rüegg, C., & Líénard, D. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80226-4 · Cited by 243 · see citing works

Deactivation of vascular endothelium by monoclonal anti–tumor necrosis factor α antibody in rheumatoid arthritis

Paleolog, E. M., Hunt, M., Elliott, M. J., Feldmann, M., Maini, R. N., & Woody, J. N. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390703 · Cited by 240 · see citing works

Constitutive Expression and Role of the TNF Family Ligands in Apoptotic Killing of Tumor Cells by Human NK Cells

Kashii, Y., Giorda, R., Herberman, R. B., Whiteside, T. L., & Vujanović, N. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5358 · Cited by 220 · see citing works

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis

Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 213 · see citing works

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons.

Balkwill, F. R., Lee, A., Aldam, G., et al. (1986) · PubMed · Cited by 212 · see citing works

Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression.

Wu, S. M., Boyer, C. M., Whitaker, R. S., Berchuck, A., Wiener, J. R., Weinberg, J. B., & Bast, R. C. (1993) · PubMed · Cited by 208 · see citing works

Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma

Leek, R., Landers, R. J., Fox, S. B., Ng, F. C., Harris, A. L., & Lewis, C. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.373 · Cited by 207 · see citing works

Tumour necrosis factor in man: Clinical and biological observations

Selby, P. J., Hobbs, S., Viner, C., Jackson, E. B., Jones, A. L., Newell, D. R., Calvert, H., McElwain, T. J., Fearon, K. C. H., & HUMPHREYS, J. (1987) · British Journal of Cancer · doi:10.1038/bjc.1987.294 · Cited by 203 · see citing works

Enhancement of experimental metastasis by tumor necrosis factor.

Orosz, P., Echtenacher, B., Falk, W., Rüschoff, J., Weber, D., & Männel, D. N. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.5.1391 · Cited by 198 · see citing works

Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti- tumour necrosis factor-alpha (cA2) therapy

Brennan, F. M., Browne, K. A., Green, P. A., et al. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.6.643 · Cited by 180 · see citing works

Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease

Foà, R., Massaia, M., Cardona, S., et al. (1990) · Blood · doi:10.1182/blood.v76.2.393.393 · Cited by 171 · see citing works

Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation.

Komori, A., Yatsunami, J., Suganuma, M., Okabe, S., Abe, S., Sakai, A., Sasaki, K., & Fujiki, H. (1993) · PubMed · Cited by 162 · see citing works

Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas.

Nawroth, P. P., Handley, D. A., Matsueda, G. R., de Waal, R., Gerlach, H., Blohm, D. H., & Stern, D. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.2.637 · Cited by 159 · see citing works

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

Malik, S., Naylor, M. S., East, N., Oliff, A., & Balkwill, F. R. (1990) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(90)90044-t · Cited by 153 · see citing works

TNF- α augments intratumoural concentrations of doxorubicin in TNF- α -based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects

Veen, A. H. V. D., de Wilt, J. H. W., Eggermont, A. M. M., van Tiel, S. T., Seynhaeve, A. L. B., & ten Hagen, T. L. M. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.1027 · Cited by 150 · see citing works

Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease

Foà, R., Massaia, M., Cardona, S., et al. (1990) · Blood · doi:10.1182/blood.v76.2.393.bloodjournal762393 · Cited by 139 · see citing works

The p55 TNF-α Receptor Plays a Critical Role in T Cell Alloreactivity

Hill, G. R., Teshima, T., Rebel, V. I., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.656 · Cited by 131 · see citing works

Immunomodulatory properties of recombinant murine and human tumor necrosis factor.

Talmadge, J. E., Phillips, H., Schneider, M., Rowe, T., Pennington, R. M., Bowersox, O., & Lenz, B. F. (1988) · PubMed · Cited by 129 · see citing works

Association between tumor necrosis factor in serum and cachexia in patients with prostate cancer.

Nakashima, J., Tachibana, M., Ueno, M., Miyajima, A., Baba, S., & Murai, M. (1998) · PubMed · Cited by 128 · see citing works

Expression of tumour necrosis factor (TNFα) and its receptors in benign and malignant breast tissue

Miles, D. W., Happerfield, L. C., Naylor, M. S., Bobrow, L. G., Rubens, R. D., & Balkwwill, F. R. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560603 · Cited by 124 · see citing works

Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor.

Creasey, A. A., Reynolds, M., & Laird, W. (1986) · PubMed · Cited by 123 · see citing works

Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice.

Yoneda, T., Alsina, M. A., Chavez, J. B., Bonewald, L. F., Nishimura, R., & Mundy, G. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115106 · Cited by 122 · see citing works

Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia.

Watanabe, N., Niitsu, Y., Umeno, H., Sone, H., Neda, H., Yamauchi, N., Maeda, M., & Urushizaki, I. (1988) · PubMed · Cited by 122 · see citing works

TNF- alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression.

Battegay, E., Raines, E. W., Colbert, T., & Ross, R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.6040 · Cited by 120 · see citing works

Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice

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Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice

Samaniego, F., Markham, P. D., Gendelman, R., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1887 · Cited by 118 · see citing works

Comparative Effects of Interleukin-1 and Tumor Necrosis Factor-α on Collagen Production and Corresponding Procollagen mRNA Levels in Human Dermal Fibroblasts

Mauviel, A., Heino, J., Kähäri, V., Hartmann, D.-J., Loyau, G., Pujol, J.-P., & VUORIO, E. I. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12462185 · Cited by 116 · see citing works

Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats

de Wilt, J. H. W., Manusama, E. R., van Tiel, S. T., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690335 · Cited by 115 · see citing works

A phase I clinical trial of recombinant human tumor necrosis factor

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Tumor necrosis factor ligand-receptor system can predict treatment outcome in lymphoma patients.

Warzocha, K., Salles, G., Bienvenu, J., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.2.499 · Cited by 112 · see citing works

TUMOR NECROSIS FACTOR-α REPRESSES ANDROGEN SENSITIVITY IN THE LNCaP PROSTATE CANCER CELL LINE

Mizokami, A., Gotoh, A., YAMADA, H., et al. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67318-1 · Cited by 99 · see citing works

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

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Regulation of monocyte MMP-9 production by TNF-α and a tumour-derived soluble factor (MMPSF)

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Expression of interleukin‐1β and tumour necrosis factor‐α in plasma cells from patients with multiple myeloma

Sati, H. I. A., Greaves, M., Apperley, J. F., et al. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01193.x · Cited by 92 · see citing works

Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors

Negus, R. P. M., Turner, L., Burke, F., & Balkwill, F. R. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.6.758 · Cited by 92 · see citing works

High-Producer Haplotypes of Tumor Necrosis Factor Alpha and Lymphotoxin Alpha Are Associated With an Increased Risk of Myeloma and Have an Improved Progression-Free Survival After Treatment

Davies, F. E., Rollinson, S. J., Rawstron, A. C., Roman, E., Richards, S. J., Drayson, M. T., Child, J. A., & Morgan, G. J. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.15.2843 · Cited by 92 · see citing works

Synergistic effects of TNF-α and melphalan in an isolated limb perfusion model of rat sarcoma: a histopathological, immunohistochemical and electron microscopical study

Nooijen, P. T. G. A., Manusama, E. R., Eggermont, A. M. M., et al. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.652 · Cited by 86 · see citing works

The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.

North, R. J., & Havell, E. A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.1086 · Cited by 83 · see citing works

FREQUENT GENOTYPE CHANGES AT ???308, AND 488 REGIONS OF THE TUMOR NECROSIS FACTOR - ?? (TNF-??) GENE IN PATIENTS WITH PROSTATE CANCER

Oh, B. R., Sasaki, M., PERINCHERY, G., Ryu, S. B., Park, Y. I., Carroll, P. R., & Dahiya, R. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67683-5 · Cited by 81 · see citing works

Crucial Role of TNF-α in CD8 T Cell-Mediated Elimination of 3LL-A9 Lewis Lung Carcinoma Cells In Vivo

Prévost‐Blondel, A., Roth, E., Rosenthal, F. M., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3645 · Cited by 80 · see citing works

Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts

Gordon, H., Kucera, G., Salvo, R., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.12.4021 · Cited by 63 · see citing works

Tumor Necrosis Factor Sustains the Generalized Lymphoproliferative Disorder ( gld ) Phenotype

Körner, H., Cretney, E., Wilhelm, P., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.89 · Cited by 59 · see citing works

Cytokines in non-genotoxic hepatocarcinogenesis

Roberts, R. A. (1999) · Carcinogenesis · doi:10.1093/carcin/20.8.1397 · Cited by 58 · see citing works

Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden.

Ghaderi, M., Никитина, Л. О., Peacock, C. S., et al. (2000) · PubMed · Cited by 49 · see citing works

Influence of Hypoxia and Glucose Deprivation on Tumour Necrosis Factor-Alpha and Granulocyte- Macrophage Colony-Stimulating Factor Expression in Human Cultured Monocytes

Guida, E., & Stewart, A. G. (1998) · Cellular Physiology and Biochemistry · doi:10.1159/000016272 · Cited by 44 · see citing works

Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas

Hajeer, A. H., Lear, J. T., Ollier, W., et al. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03353.x · Cited by 44 · see citing works

Serum levels of p55 and p75 soluble TNF receptors in adult acute leukaemia at diagnosis: correlation with clinical and biological features and outcome

Vinante, F., Rigo, A., Tecchio, C., et al. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00872.x · Cited by 43 · see citing works

Anti-TNF antibody treatment of Crohn's disease

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Inhibitation of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline

Robertson, F. M., Ross, M. S., Tober, K. L., Long, B. W., & Oberyszyn, T. M. (1996) · Carcinogenesis · doi:10.1093/carcin/17.8.1719 · Cited by 37 · see citing works

Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis

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Elevated circulating levels of tumor necrosis factor predict unresponsiveness to treatment with interferon alfa-2b in chronic myelogenous leukemia.

Herrmann, F., Helfrich, S. G., Lindemann, A., et al. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.4.631 · Cited by 28 · see citing works

TNF Receptors in Chronic Lymphocytic Leukemia

Waage, A., & Espevik, T. (1994) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199409051650 · Cited by 23 · see citing works

Soluble Tumor Necrosis Factor Receptor Type I Enhances Tumor Development and Persistence in Vivo

Selinsky, C. L., & Howell, M. D. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1622 · Cited by 18 · see citing works

Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration

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