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The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion

Swayampakula, M, McDonald, P C, Vallejo, M, Coyaud, E, Chafe, S C, Westerback, A, Venkateswaran, G, Shankar, J, Gao, G, Laurent, E M N, Lou, Y, Bennewith, K L, Supuran, C T, Nabi, I R, Raught, B, Dedhar, S·2017·Oncogene
DOI 10.1038/onc.2017.219PMC PMC5684442
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  • MT1-MMP is highly expressed in various types of cancer cells and promotes cancer metastasis and angiogenesis.

    “It is well documented that MT1-MMP is highly expressed in various types of cancer cells and promotes cancer metastasis and angiogenesis16,44,47–50.”

    From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [50]

    The Discussion links MMP14 (MT1-MMP) expression to cancer progression and metastasis and reports significant expression in subsets of triple-negative breast tumors. It does not establish high expression across various cancer-cell types or say that MT1-MMP promotes angiogenesis; a search for MMP14 and angiogenesis found no supporting passage. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Metadata

Authors
Swayampakula, M., McDonald, P. C., Vallejo, M., Coyaud, E., Chafe, S. C., Westerback, A., Venkateswaran, G., Shankar, J., Gao, G., Laurent, E. M. N., Lou, Y., Bennewith, K. L., Supuran, C. T., Nabi, I. R., Raught, B., & Dedhar, S.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2017-07-10
Volume
36
Issue
45
Pages
6244-6261
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/onc.2017.219
PMC
PMC5684442
Cited by
130
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0 (tdm)

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