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Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway
Open accessAbstract
Salmonella infections can become chronic and increase the risk of cancer. The mechanisms by which specific Salmonella organisms contribute to cancer, however, are still unknown. Live and attenuated Salmonella are used as vectors to target cancer cells, but there have been no systematic studies of the oncogenic potential of chronic Salmonella infections in cancer models. AvrA, a pathogenic product of Salmonella, is inserted into host cells during infection and influences eukaryotic cell pathways. In the current study, we colonized mice with Salmonella AvrA-sufficient or AvrA-deficient Salmonella typhimirium strains and induced inflammation-associated colon cancer by azoxymethane/dextran sulfate sodium (AOM/DSS). We confirmed Salmonella persisted in the colon for up to 45 weeks. Salmonella was identified not only in epithelial cells on the colonic luminal surface and base of the crypts but also in invading tumors. Tumor incidence in the AvrA+infected group was 100% compared with 51.4% in the AOM/DSS group without bacterial gavage and 56.3% in mice infected with the AvrA- strain. Infection with AvrA+ strain also altered tumor distribution from the distal to proximal colon that might reflect changes in the microbiome. AvrA-expressing bacteria also upregulated beta-catenin signaling as assessed by decreased beta-catenin ubiquitination, increased nuclear beta-catenin and increased phosphorylated-beta-catenin (Ser552), a marker of proliferating stem-progenitor cells. Other β-catenin targets increased by AvrA included Bmi1, a cancer stem cell marker, matrix metalloproteinase-7, and cyclin D1. In summary, AvrA-expressing Salmonella infection activates β-catenin signals and enhances colonic tumorigenesis. Our findings provide important new mechanistic insights into how a bacterial protein targets proliferating stem-progenitor cells and contributes to cancer development. Our observations also raise a note of caution regarding the use of mutant Salmonella organisms as vectors for anti-cancer therapy. Finally, these studies could suggest biomarkers (such as AvrA level in gut) to assess cancer risk in susceptible individuals and infection-related dysregulation of β-catenin signaling in cancer.
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“AvrA, a pathogenic product of Salmonella, has been shown to activate β-catenin signals and enhance colonic tumorigenesis.99”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [99]
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“In the same direction, the Salmonella enterica effector avirulence protein A (AvrA) is able to translocate into host’s cells and activate β-catenin via its intrinsic de-ubiquitinase activity [70].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [70]
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Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,781
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Self-citationSellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Bmi1 is expressed in vivo in intestinal stem cells
Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,243
Gastric Cancer Originating from Bone Marrow-Derived Cells
Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J. E., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., & Wang, T. C. (2004) · Science · doi:10.1126/science.1099513 · Cited by 1,174
Dieleman, L. A., Palmen, M. J. H. J., Akol, H., Bloemena, E., Peña, A. S., Meuwissen, S. G. M., & van Rees, E. P. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00728.x · Cited by 1,167
Mantovani, A. (2008) · Nature · doi:10.1038/457036b · Cited by 657
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Items 101–200 of 205
Xu, J., Jia, S., Ren, Y., Zhang, Y., Zhang, J., Tang, C., Kan, J., Liu, J., & Wang, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106769 · Cited by 14
Self-citationThe microbial landscape of tumors: a deep dive into intratumoral microbiota
Asgharzadeh, S., Pourhajibagher, M., & Bahador, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1542142 · Cited by 16
Zhou, P., Zhang, W., Liao, Y., Zhai, Z., Lu, S., Jiang, S., Hu, W., & Gong, W. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002573 · Cited by 17
Microbiome-targeted nanoplatforms and engineering approaches in breast cancer therapy
Sabeel, Z., & Zhao, Y. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02456-x · Cited by 17
Pani, G. (2023) · Cancers · doi:10.3390/cancers15092583 · Cited by 16
Salmonella infection acts as an environmental risk factor for human colon cancer
Shanker, E., & Sun, J. (2023) · Cell Insight · doi:10.1016/j.cellin.2023.100125 · Cited by 13
Self-citationStaphylococcus aureus lipid factors modulate melanoma cell clustering and invasion
Giese, M. A., Ramakrishnan, G., Steenberge, L. H., Dovan, J. X., Sauer, J., & Anna Huttenlocher, A. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050770 · Cited by 13
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation
Wang, D., Ni, J., Li, J., Gao, Y., Ni, F., Zhang, Z., Fang, J., Lu, J. L., & Yao, Y. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011189 · Cited by 14
Editorial on "Cancer and the microbiota" published in Science.
Hamm, A. K., & Weir, T. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.07.16 · Cited by 14
Garavaglia, B., Vallino, L., Ferraresi, A., Visciglia, A., Amoruso, A., Pane, M., Munteanu, C., & Isidoro, C. (2025) · Biomedicines · doi:10.3390/biomedicines13071554 · Cited by 13
Arsenault, R. J., Genovese, K. J., He, H., Wu, H., Neish, A. S., & Kogut, M. H. (2015) · Poultry Science · doi:10.3382/ps/pev344 · Cited by 12
Role of the Microbiome in the Diagnosis and Management of Gastroesophageal Cancers
Mascaretti, F., Haider, S., Amoroso, C., Caprioli, F., Ramai, D., & Ghidini, M. (2024) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-024-01021-x · Cited by 12
Intratumoral microorganisms in tumors of the digestive system
Xuan, M., Gu, X., Liu, Y., Li, Y., Li, Y., Huang, D., Li, J., & Xue, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01425-5 · Cited by 13
Qiu, J., Jiang, Y., Ye, N., Jin, G., Shi, H., & Qian, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05531-x · Cited by 13
Gut and Intratumoral microbiota: Key to lung Cancer development and immunotherapy
Cai, J., Zhang, W., Zhu, S., Lin, T., Mao, R., Wu, N., Zhang, P., & Kang, M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114677 · Cited by 12
Chang, C., & Lam, H. Y. P. (2024) · Anticancer Research · doi:10.21873/anticanres.17035 · Cited by 14
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Ijaz, F., Sameeullah, M., Farid, A., Malik, M. S., Batool, N., Mirza, B., Timko, M. P., Liu, H., Lössl, A. G., & Waheed, M. T. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107225 · Cited by 10
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Thomas, R. M. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101128 · Cited by 10
Role of human microbiota in the development of colorectal cancer
Kochkina, S. O., Гордеев, С. С., & Mamedli, Z. Z. (2019) · Surgery and Oncology · doi:10.17650/2686-9594-2019-9-3-11-17 · Cited by 9
Microbiota-associated mechanisms in colorectal cancer
González, A., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.05.002 · Cited by 8
Beyond Tumor Borders: Intratumoral Microbiome Effects on Tumor Behavior and Therapeutic Responses
Harmak, Z., Kone, A.-S., Ghouzlani, A., Ghazi, B., & Badou, A. (2024) · Immune Network · doi:10.4110/in.2024.24.e40 · Cited by 8
Zhou, Q., Zhou, L., Chen, X., Chen, Q., & Hao, L. (2024) · Cancer Reports · doi:10.1002/cnr2.70063 · Cited by 8
Fan, Y., Gu, X., Yang, H., Chen, Y., Fang, C., Deng, H., & Dai, L. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00376-2 · Cited by 8
The Effect of Salmonella AvrA Infection on Colon Cancer: An in-silico Study
Wibowo, B. P., Kalim, H., Khotimah, H., Sujuti, H., & Wibowo, R. M. D. (2023) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2023.24.1.163 · Cited by 7
Chang, R., Wei, J. C., Lin, M., & Hung, Y. (2020) · Gastric Cancer · doi:10.1007/s10120-020-01132-x · Cited by 7
Microbiome, a new dimension in cancer research.
Neto, A. G., Bradshaw, A.-D., & Pei, Z. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.08.07 · Cited by 7
Microbiome in Colonic Carcinogenesis
Sun, J., & Xia, Y. (2023) · Comprehensive physiology · doi:10.1002/cphy.c210052 · Cited by 10
Self-citationResident Microbiome of Kidney Tumors
Kovaleva, O. V., Алексеевна, П. П., & Gratchev, A. N. (2024) · Oncology Reviews · doi:10.3389/or.2024.1393664 · Cited by 6
RETRACTED: Understanding microbiota-driven oncogenesis: The role of metabolites in tumorigenesis
Ullah, S., Wu, C., Zou, X., Zhong, Y., Ahmad, A., Jan, A. U., Cong, Y., Chen, Y., & Li, L. (2025) · iScience · doi:10.1016/j.isci.2025.113945 · Cited by 8
Self-citationRetractedBiswas, P., Pal, S., Das, M., & Dam, S. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_159-1 · Cited by 6
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Bleich, R. M., & Arthur, J. C. (2021) · Physiology in health and disease · doi:10.1007/978-3-030-67951-4_1 · Cited by 8
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Kapoor, S., Gupta, M., Sapra, L., Kaur, T., & Srivastava, R. K. (2024) · Bone Reports · doi:10.1016/j.bonr.2024.101809 · Cited by 5
Wang, J., Su, Z., Zhang, X., Wang, S., Chen, X., Xu, X., He, B., & Zheng, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123915 · Cited by 5
Self-citationGut microbiota drives cancer evolution and therapy resistance
Min, S., Zhang, Y., Zhang, H., & Liu, Q. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02564-8 · Cited by 8
Self-citationZhang, L., Duan, X., Zhao, Y., Zhang, D., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526589 · Cited by 5
Self-citationSutar, A., Dashpute, R. S., Shinde, Y. D., Mukherjee, S., & Chowdhury, C. (2023) · Indian Journal of Microbiology · doi:10.1007/s12088-023-01176-4 · Cited by 6
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Watson, M. M., van der Giezen, M., & Søreide, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00012-8 · Cited by 5
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Stévenin, V., & Neefjes, J. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00812-z · Cited by 4
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Poveshchenko, A. F., Cherkas, V. N., Кабаков, А. В., & Васильевич, К. О. (2023) · Journal of microbiology epidemiology immunobiology · doi:10.36233/0372-9311-356 · Cited by 5
Chopra, U., Sabu, M. K., Rajmani, R. S., Chaudhary, A. D., Gupta, S. K., & Chakravortty, D. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf131 · Cited by 4
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Chen, J., Bai, Y., Shen, L., Ying, J., Xu, J. Q., Tang, J., & Bao, Y.-J. (2026) · MedComm · doi:10.1002/mco2.70825 · Cited by 3
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Dasgupta, N., Srivastava, A., Rao, A., Murugkar, V., Shroff, R., & Das, G. (2021) · Springer eBooks · doi:10.1007/978-981-16-3156-6_10 · Cited by 3
Human microbiota: role in cancer progression and therapy
Rais, A., Chand, P., Malik, M., & Prasad, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96128-8.00006-7 · Cited by 3
Biswas, P., Pal, S., Das, M., & Dam, S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_159 · Cited by 3
Pavon, R. D. N., & Rivera, W. L. (2023) · Microbiology and Biotechnology Letters · doi:10.48022/mbl.2306.06010 · Cited by 3
TLR4/NF-kB/β-Catenin/TGF-β pathways in Salmonella AvrA related-Colorectal Cancer Tumorigenesis
Wibowo, B. P., Kalim, H., Khotimah, H., Sujuti, H., & Rukmigarsari, E. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00406 · Cited by 3
Pan, W. D., & Kang, Y. (2017) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000120 · Cited by 3
Satuman, S., Sari, D. S., Rachmi, E., Tanggo, E. H., Notobroto, H. B., Sudiana, K., Mubarika, S., Rantam, F. A., Soemarno, S., & Wasito, E. B. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.4945 · Cited by 3
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Self-citationWu, Y., Zhou, M., Wan, Y., Wei, K., Ma, S., Cheng, L., Lin, T., He, L., He, Y., & Zhou, F. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1695187 · Cited by 2
Yun, C.-H., Kao, W.-C., Hsu, C. Y., Chang, R., Cheng, M., & Hung, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912943 · Cited by 2
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Hernández-Luna, M. A., Muñoz-López, P., Aguilar-González, C. A., & Lurı́a-Pérez, R. (2018) · InTech eBooks · doi:10.5772/intechopen.75481 · Cited by 2
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Vecherkovskaya, M. F., Tetz, G. V., & Tetz, V. (2021) · The Scientific Notes of the Pavlov University · doi:10.24884/1607-4181-2020-27-4-14-27 · Cited by 2
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Wibowo, B. P., Kalim, H., Khotimah, H., Sujuti, H., Rukmigarsari, E., & Erwan, N. E. (2023) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v15i6.2607 · Cited by 1
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Yu, A. I., & Chen, G. (2021) · Physiology in health and disease · doi:10.1007/978-3-030-67951-4_3 · Cited by 2
Kuete, V. (2024) · Advances in botanical research · doi:10.1016/bs.abr.2024.01.008 · Cited by 1
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Nezhadi, J., Kafil, H. S., Mahdavi, F., Sadrkabir, M., Hashemzadeh, S., Moaddab, S. Y., Nouri, R., Mohammadzadeh-Asl, Y., Sattarpour, S., & Rezaee, M. A. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010338997241216053634 · Cited by 1
Liu, X., Cai, R., Meng, Y., Xu, Y., Wang, B., Liu, M., Wang, Y., Yu, Y., Lu, C., Wei, Y., et al. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105220 · Cited by 1
Self-citationSohel, M., Aktar, S., Khatun, S., Hamidu, S., Nity, N. U., Kumar, S., Hossain, M. S., Sarker, M. R., Das, S. R., Dey, B. R., et al. (2026) · BioMed Research International · doi:10.1155/bmri/6359088 · Cited by 1
Li, Y., Yang, Y., Zhang, X., Huang, Z., Zhang, X., & Wen, J. (2026) · Virulence · doi:10.1080/21505594.2026.2696642 · Cited by 1
Williams, C. K. O. (2018) · Springer eBooks · doi:10.1007/978-3-319-99235-8_4 · Cited by 1
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Liu, X., & Sun, J. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7534-1_4
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Condé, R., Diego, P.-D. L. R. J., Luis, L.-A., Homero, H. S., Karina, R.-M., Edmundo, R.-R. E., & Sachman-Ruíz, B. (2018) · Advances in Microbiology · doi:10.4236/aim.2018.87031
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Tian, J. S. (2021) · International Conference on Bioinformatics and Biomedical Science (ICBBS) · doi:10.1145/3498731.3498757
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Saw, P. E., & Song, E. (2023) · Springer eBooks · doi:10.1007/978-981-99-1183-7_25
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Ochioni, A. C., Panzenhagen, P., Vieira, C. P., & Conte‐Júnior, C. A. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_264
Chopra, U., Sabu, M. K., Rajmani, R. S., Chaudhary, A. D., Gupta, S. K., & Chakravortty, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.29.620790
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Mousa, W. K., Ali, A., Abdelmoteleb, R. W. A., Shami, R. A., Alramadan, N., Moutraji, S. A., & Ghemrawi, R. (2025) · Targeted Cancer Therapy Connect · doi:10.69709/ciconnect.2025.154988
Wang, F., Luan, X., Ma, H., Wang, X., Chen, M., & Xu, Y. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00759-4
Al-Janabi, I. I. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v10i1.2474
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Metadata
- Authors
- Lu, R., Wu, S., Zhang, Y.-G., Xia, Y., Liu, X., Zheng, Y., Chen, H., Schaefer, K. L., Zhou, Z., Bissonnette, M., Li, L., & Sun, J.
- Affiliations
- Rush University (US)
- University of Rochester (US)
- University of Rochester Medicine (US)
- University of Chicago (US)
- Stowers Institute for Medical Research (US)
- Corresponding author
- Sun, J
- Venue
- Oncogenesis
- Published
- 2014-06-09
- Volume
- 3
- Issue
- 6
- Pages
- e105-e105
- ISSN
- 2157-9024 (ISSN-L)
- PMC
- PMC4150214
- OpenAlex
- W1968540478
- Cited by
- 206
- References
- 47
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 21 · 2023: 27 · 2022: 16 · 2021: 26 · 2020: 18 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 13 · 2014: 2
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Oncogenesis (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Cancer Institute (R01CA164124)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK075386, DK075386, KO1-DK-075386)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- avrA, Salmonella typhimurium, colon carcinogenesis, β-catenin signaling, chronic bacterial infection, cancer stem cells, BMI1, matrix metalloproteinase-7, cyclin D1, stem/progenitor cells, gut microbiota
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