The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators
Open accessAbstract
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis.
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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Nguyen, T. T., Wei, S., Nguyen, T. H., Jo, Y., Zhang, Y., Park, W., Gariani, K., Oh, C.-M., Kim, H. H., Ha, K.-T., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01046-5 · Cited by 325
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Labiano, I., Agirre-Lizaso, A., Olaizola, P., Echebarria, A., Huici-Izagirre, M., Olaizola, I., Esparza-Baquer, A., Sharif, O., Hijona, E., Milkiewicz, P., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.05.044 · Cited by 78
Navigating the complexities of cell death: Insights into accidental and programmed cell death
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Metadata
- Authors
- Seo, J., Nam, Y. W., Kim, S., Oh, D.-B., & Song, J.
- Venue
- Experimental & Molecular Medicine
- Published
- 2021-06
- Volume
- 53
- Issue
- 6
- Pages
- 1007-1017
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W3165440308
- Cited by
- 312
- References
- 96
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- gold
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