The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Tumor microenvironment and radioresistance
Open accessAbstract
Metastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in appropriate soil, considerable attention has focused on both extracellular environmental factors that affect the growth of cancer cells and the tissue structure that influences the microenvironment. Malignant tumor tissues consist of not only cancer cells but also a wide variety of other cells responsible for the inflammatory response, formation of blood vessels, immune response, and support of the tumor tissue architecture, forming a complex cellular society. It is also known that the amounts of oxygen and nutrients supplied to each cell differ depending on the distance from tumor blood vessels in tumor tissue. Here, we provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells, focusing on the following keywords: diversity of oxygen and nutrient microenvironment in tumor tissue, inflammation, immunity, and tumor vasculature.
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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Choi, Y., & Jung, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01114-w · Cited by 188
Mitochondrial Metabolism: A New Dimension of Personalized Oncology
Behnam, B., & Taghizadeh-Hesary, F. (2023) · Cancers · doi:10.3390/cancers15164058 · Cited by 44
Lee, J. W., Park, S.-H., Ahn, H., Lee, S. M., & Jang, S. J. (2021) · Cancers · doi:10.3390/cancers13143563 · Cited by 18
Li, P., Dong, Z., Jiang, Q., Yu, C., Liu, Y., Yuan, R., Qiu, Y., Meng, T., Hu, F., & Yuan, H. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114406 · Cited by 6
Metadata
- Authors
- Suwa, T., Kobayashi, M., Nam, J.-M., & Harada, H.
- Venue
- Experimental & Molecular Medicine
- Published
- 2021-06
- Volume
- 53
- Issue
- 6
- Pages
- 1029-1035
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W3168669958
- Cited by
- 179
- References
- 16
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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