Female infertility: which role for obesity?
Open accessAbstract
Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium functions, with a final alteration in oocyte maturation and endometrial epithelium receptivity. In addition, through the development of peripheral insulin resistance obesity produces a condition of functional hyperandrogenism and hyperestrogenism that contribute to produce anovulation and to reduce endometrial receptivity and, therefore participate to cause infertility. Weight loss is able to restore fertility in most cases, but there are no practical indications to guide the clinician to choice the best method among increased physical activity, diet, drugs, and bariatric surgery.
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Both underweight and obesity are associated with menstrual cycle disorders including anovulation, amenorrhea and oligorrhea.
“Both underweight and obesity are associated with menstrual cycle disorders including anovulation, amenorrhea and oliogorrhea.”
From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [22]
In obesity, women develop leptin resistance leading to cycle disorders.
“In obesity, women develop leptin resistance leading to cycle disorders. 22”
From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [22]
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- Authors
- on behalf of the Obesity Programs of nutrition, E., Gambineri, A., Laudisio, D., Marocco, C., Radellini, S., Colao, A., & Savastano, S.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Federico II University Hospital (IT)
- Foro Italico University of Rome (IT)
- University of Palermo (IT)
- Corresponding author
- Gambineri, Alessandra
- Venue
- International Journal of Obesity Supplements
- Published
- 2019-04
- Volume
- 9
- Issue
- 1
- Pages
- 65-72
- ISSN
- 2046-2166 (ISSN-L)
- 2046-2174
- PMC
- PMC6683114
- OpenAlex
- W2939019398
- Cited by
- 114
- References
- 5
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 30 · 2021: 21 · 2020: 11
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity Supplements (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- female infertility, obesity, adipose tissue, leptin, free fatty acids, cytokines, ovarian function, endometrial receptivity, oocyte maturation, insulin resistance, hyperandrogenism, hyperestrogenism, anovulation, weight loss, bariatric surgery, physical activity, diet
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