Cited by 31Reproductive Biology and FertilityOvarian function and disordersReproductive Physiology in Livestock

Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers

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Wołodko, Karolina, Castillo-Fernandez, Juan, Kelsey, Gavin, Galvão, António·2021·International Journal of Molecular Sciences

Abstract

The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.

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Crossref · 10.3390/ijms22084270

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  • Feedback mechanisms associated with leptin resistance and hyperinsulinemia intensify hormonal imbalances, obstructing follicle maturation and oocyte development.

    “The feedback mechanisms associated with leptin resistance and hyperinsulinemia intensify hormonal imbalances, obstructing follicle maturation and oocyte development [94].”

    From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [94]

    Section 2 links obesity-associated hyperinsulinemia to delayed oocyte maturation, while §5.3 links it to increased ovarian androgen production and follicular atresia. The Conclusions link altered leptin signaling and leptin resistance to disrupted follicular growth, steroidogenesis, and possible impairment of oocyte maturation. The paper does not establish the specific feedback mechanism between leptin resistance and hyperinsulinemia that the sentence asserts. (LLM, conf=0.85)

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Authors
Wołodko, K., Castillo-Fernandez, J., Kelsey, G., & Galvão, A.
Affiliations
  • InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
  • Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK
  • Babraham Institute (GB)
Corresponding author
Galvão, António
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-04-20
Volume
22
Issue
8
Pages
4270
ISSN
1422-0067 (ISSN-L)
OpenAlex
W3153141798
Cited by
31
References
152
Citations by year
2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 3
FWCI
0.98
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Apollo
  • Apollo (cc-by)
Funders
Polish National Science Centre (2016/23/B/NZ4/03737, 2019/34/E/NZ4/00349)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Keywords
leptin signaling, maternal obesity, folliculogenesis, oocyte maturation, hyperleptinemia, hyperestrogenism, adipose tissue, oocyte developmental competence, ovarian function
MeSH terms
Animals, Cell Differentiation, Female, Ovarian Follicle, Humans, Models, Biological, Mothers, Obesity, Oocytes, Oogenesis, Ovulation, Pregnancy, Signal Transduction, Biomarkers, Gene Expression Regulation, Developmental, Leptin, Mice, Adipokines

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