Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
Open accessAbstract
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
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Feedback mechanisms associated with leptin resistance and hyperinsulinemia intensify hormonal imbalances, obstructing follicle maturation and oocyte development.
“The feedback mechanisms associated with leptin resistance and hyperinsulinemia intensify hormonal imbalances, obstructing follicle maturation and oocyte development [94].”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [94]
Section 2 links obesity-associated hyperinsulinemia to delayed oocyte maturation, while §5.3 links it to increased ovarian androgen production and follicular atresia. The Conclusions link altered leptin signaling and leptin resistance to disrupted follicular growth, steroidogenesis, and possible impairment of oocyte maturation. The paper does not establish the specific feedback mechanism between leptin resistance and hyperinsulinemia that the sentence asserts. (LLM, conf=0.85)
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- Authors
- Wołodko, K., Castillo-Fernandez, J., Kelsey, G., & Galvão, A.
- Affiliations
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK
- Babraham Institute (GB)
- Corresponding author
- Galvão, António
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-04-20
- Volume
- 22
- Issue
- 8
- Pages
- 4270
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8074257
- OpenAlex
- W3153141798
- Cited by
- 31
- References
- 152
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 3
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Apollo
- Apollo (cc-by)
- Funders
- Polish National Science Centre (2016/23/B/NZ4/03737, 2019/34/E/NZ4/00349)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- leptin signaling, maternal obesity, folliculogenesis, oocyte maturation, hyperleptinemia, hyperestrogenism, adipose tissue, oocyte developmental competence, ovarian function
- MeSH terms
- Animals, Cell Differentiation, Female, Ovarian Follicle, Humans, Models, Biological, Mothers, Obesity, Oocytes, Oogenesis, Ovulation, Pregnancy, Signal Transduction, Biomarkers, Gene Expression Regulation, Developmental, Leptin, Mice, Adipokines
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