The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The cytokine network involved in the host immune response to periodontitis
Open accessAbstract
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
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Cited by
Periodontal Inflammation and Systemic Diseases: An Overview
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Biomarkers Common for Inflammatory Periodontal Disease and Depression: A Systematic Review
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Metadata
- Authors
- Pan, W., Wang, Q., & Chen, Q.
- Venue
- International Journal of Oral Science
- Published
- 2019-09
- Volume
- 11
- Issue
- 3
- Pages
- 30-30
- ISSN
- 1674-2818 (ISSN-L)
- 2049-3169
- OpenAlex
- W2984719377
- Cited by
- 696
- References
- 46
- FWCI
- 50.38
- Type
- journal article
- Language
- en
- Open access
- gold
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