The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis
Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) occurs in an age-related manner and associates with an increased risk of hematologic cancer, atherosclerotic disease, and shorter overall survival. Little is known about the cell of origin, repartition patterns of clonal mutations within the hematopoietic differentiation tree, and its dynamics under evolutionary pressure. Using targeted sequencing, CHIP was identified in 121 out of 437 elderly individuals (27.7%). Variant allele frequencies (VAFs) of 91 mutations were studied in six peripheral blood cell fractions. VAFs were significantly higher in monocytes, granulocytes, and NK-cells compared to B- or T cells. In all cases with available bone marrow material, mutations could be identified in Lin - CD34 + CD38 - HSCs with subsequent expansion to myeloid primed progenitors. In 22 patients with solid cancer receiving (radio-)chemotherapy, longitudinal study of 32 mutations at 121 time points identified relative VAF changes of at least 50% in 13/32 mutations. VAFs of DNMT3A, were stable in 12/13 cases (P < .001). Cancer patients with a clonal mutation other than DNMT3A required more often red blood cell transfusions and dose reductions. Our results provide novel insights into cellular distribution of clonal mutations, their dynamics under chemotherapy, and advocate for systematic analyses for CHIP in cancer patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CHIP mutations originate in multipotent HSCs, the clonal progeny is predominantly concentrated within the myeloid compartment, specifically affecting monocytes and granulocytes, with a significantly lower mutational burden observed in lymphoid cells [29].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [29]
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
Circos: An information aesthetic for comparative genomicsPreprint
Krzywinski, M. I., Schein, J. E., Birol, İ., Connors, J. M., Gascoyne, R. D., Horsman, D. E., Jones, S. J. M., & Marra, M. A. (2009) · Genome Research · doi:10.1101/gr.092759.109 · Cited by 11,073
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Aligning sequence reads, clone sequences and assembly con*gs with BWA-MEMPreprint
Li, H. (2014) · arXiv (Cornell University) · doi:10.6084/m9.figshare.963153.v1 · Cited by 5,155
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencingPreprint
Koboldt, D. C., Zhang, Q., Larson, D. E., Shen, D., McLellan, M. D., Lin, L., Miller, C. A., Mardis, E. R., Ding, L., & Wilson, R. K. (2012) · Genome Research · doi:10.1101/gr.129684.111 · Cited by 4,954
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–195 of 195
TET2 missense variants in human neoplasia. A proposal of structural and functional classification
Bussaglia, E., Antón, R. I., Nomdedeu, J. F., & Fuentes‐Prior, P. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.772 · Cited by 14
Sant’Antonio, E., Camerini, C., Rizzo, V., Musolino, C., & Allegra, A. (2021) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2021.04.014 · Cited by 11
DePersia, A., Knollman, H. M., Dugan, J. P., Hedeker, D., Handorf, E., Nielsen, S. M., Bealin, L., Goldblatt, L. G., Willems, H., Daly, M. B., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2471 · Cited by 11
Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., Salazar, M. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.557322 · Cited by 11
Haematopoietic ageing through the lens of single-cell technologies
Strzelecka, P. M., & Damm, F. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.047340 · Cited by 10
Self-citationThe evolution of leukaemia from pre‐leukaemic and leukaemic stem cells
Shlush, L. I., & Feldman, T. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13236 · Cited by 10
Nam, A. S., Dusaj, N. N., Izzo, F., Murali, R., Myers, R. M., Mouhieddine, T. H., Sotelo, J., Benbarche, S., Waarts, M. R., Gaiti, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.14.476225 · Cited by 10
Diagnosis of Myelodysplastic Syndromes: From Immunological Observations to Clinical Applications
Simoni, Y., & Chapuis, N. (2022) · Diagnostics · doi:10.3390/diagnostics12071659 · Cited by 9
Cosentino, C., Mouhssine, S., Zucchetto, A., Romano, I. J., Salehi, M., Cappelli, L. V., Iannelli, F., Almasri, M., Maher, N., Fumagalli, L., et al. (2026) · HemaSphere · doi:10.1002/hem3.70322 · Cited by 9
Yoroidaka, T., Hosokawa, K. T., Imi, T., Mizumaki, H., Katagiri, T., Ishiyama, K., Yamazaki, H., Azuma, F., Nanya, Y., Ogawa, S., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01202-8 · Cited by 9
Self-citationCaprioli, C., Nazari, I., Milovanovic, S., & Pelicci, P. G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.796477 · Cited by 9
Incipient clonal hematopoiesis is accelerated following CD30.CAR-T therapy
Kapadia, C. D., Rosas, G., Thakkar, S. G., Wu, M.-F., Torrano, V., Wang, T., Grilley, B., Heslop, H. E., Ramos, C. A., Goodell, M. A., et al. (2023) · Cytotherapy · doi:10.1016/j.jcyt.2023.11.013 · Cited by 9
Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes
Rocco, J. M., Zhou, Y., Liu, N., Laidlaw, E., Galindo, F., Anderson, M. V., Rupert, A. W., Lage, S. L., Ortega‐Villa, A. M., Yu, S. J., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.174783 · Cited by 10
Heumüller, A., Wehrle, J., Stosch, J. M., Niemöller, C., Bleul, S., Waterhouse, M., Uhl, D., Metzeler, K. H., Lübbert, M., Duyster, J., et al. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0575-4 · Cited by 9
Vijenthira, A., Volpe, V. O., Sekar, A., Azevedo, R. S., Mikhaleva, M., Gibson, C. J., Martindale, S. P., Fardoun, R., Tyekucheva, S., Ren, Y., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013414 · Cited by 10
Mosaic chromosomal alterations (mCAs) in individuals with monoclonal B-cell lymphocytosis (MBL)
Sekar, A., Griffin, R., Parikh, S. A., Genovese, G., Robinson, D. P., Norman, A. D., Olson, J. E., Rabe, K. G., Hoel, M. S., Boddicker, N. J., et al. (2024) · Blood Cancer Journal · doi:10.1038/s41408-024-01175-8 · Cited by 8
Implications of Clonal Hematopoiesis in Hematological and Non-Hematological Disorders
Zhang, Q., Yim, R., Lee, P., Chin, L., Li, V., & Gill, H. (2024) · Cancers · doi:10.3390/cancers16234118 · Cited by 10
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Yoshizato, T., Nilsson, C. C., Grasso, F., Högstrand, K., Mazzi, S., Winroth, A., Lehander, M., Barbosa, I., Walldin, G., Blanco, T. M., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02405-w · Cited by 8
CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC
Testa, U., Castelli, G., & Pelosi, E. (2022) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2022.069 · Cited by 9
Clonal Hematopoiesis: Origins and determinants of evolution
Mendez, L., & Patnaik, M. M. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107076 · Cited by 8
Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions
Li, C., Zhang, C., & Li, X. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05261-8 · Cited by 8
Zhao, L., Sébert, M., MEKINIAN, A., Fain, O., Espéli, M., Balabanian, K., Dulphy, N., Adès, L., & Fenaux, P. (2023) · Leukemia · doi:10.1038/s41375-023-01890-4 · Cited by 7
Sato, Y., Fukatsu, M., Suzuki, T., Sasajima, T., Gunji, N., Yoshida, S., Asano, N., Fukuchi, K., Mori, H., Takano, M., et al. (2023) · International Journal of Hematology · doi:10.1007/s12185-023-03603-0 · Cited by 8
Age-related clonal hematopoiesis: implications for hematopoietic stem cell transplantation
Abelson, S., & Wang, J. C. Y. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000465 · Cited by 8
Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
Belotserkovskaya, E., Golotin, V., Uyanik, B., & Demidov, O. N. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01590-z · Cited by 8
The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health
Kinzhebay, A., & Salybekov, A. A. (2025) · Neurology International · doi:10.3390/neurolint17020019 · Cited by 7
Stem cell concepts in myelodysplastic syndromes: lessons and challenges
Woll, P. S., & Jacobsen, S. E. W. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13283 · Cited by 7
A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology
Zerdan, M. B., Nasr, L. F., Saba, L., Meouchy, P., Safi, N., Allam, S., Bhandari, J., & Chaulagain, C. P. (2022) · Cancers · doi:10.3390/cancers14153663 · Cited by 7
Clonal Hematopoiesis: Impact on Health and Disease
Caiado, F., & Manz, M. G. (2025) · Hematological Oncology · doi:10.1002/hon.70075 · Cited by 7
Stein, C. M., Hablesreiter, R., Christen, F., Löwe, P., Torre, C. F., Kopp, K., Locher, B. N., Nitsch, L., Altwasser, R., Kerschbaum, J. F., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02823-z · Cited by 6
Self-citationSomatic mutations associate with clonal expansion of CD8 + T cells
Lundgren, S., Myllymäki, M., Järvinen, T., Keränen, M. A. I., Theodoropoulos, J., Smolander, J., Kim, D., Salmenniemi, U., Walldin, G., Savola, P., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj0787 · Cited by 8
Xi, Z., Feng, H., Chen, K., Guo, X., Zhu, D., Zheng, J., & Li, Y. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102242 · Cited by 6
Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS
Buck, M. C., Bast, L., Hecker, J. S., Rivière, J., Rothenberg‐Thurley, M., Vogel, L., Wang, D., Andrä, I., Theis, F. J., Bassermann, F. C., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107328 · Cited by 6
Clonal hematopoiesis and myeloid skewing in older population‐based individuals
van Bergen, M. G. J. M., Kamphuis, P., de Graaf, A. O., Salzbrunn, J. B., Koorenhof‐Scheele, T. N., van Zeventer, I. A., Dinmohamed, A. G., Schuringa, J. J., van der Reijden, B. A., Huls, G. A., et al. (2024) · American Journal of Hematology · doi:10.1002/ajh.27495 · Cited by 5
Chan, A. C. L., Kumar, P., Gao, Q., Baik, J., Sigler, A. M., Londono, D., Liu, Y., Arcila, M. E., Doǧan, A., Zhang, Y., et al. (2021) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.22047 · Cited by 5
Hosuru, R. V., Yang, J., Zhou, Y.-F., Gin, A. L., Hayal, T. B., Hong, S. G., Dunbar, C. E., & Wu, C. (2024) · British Journal of Haematology · doi:10.1111/bjh.19889 · Cited by 4
Emergent BAX-mutated clonal hematopoiesis after venetoclax-based therapy for breast cancer
Tiong, I. S., Nguyen, T., Chua, C. C., Teh, C. E., Muttiah, C., Ftouni, S., Seymour, J. F., Gray, D. H. D., Roberts, A. W., Dawson, S., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025016063 · Cited by 4
Lai, J., Xi, Z., Zhu, D., Zhang, Q., Yang, Y., Wang, X., Xia, B., Hou, T., & Feng, H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003060 · Cited by 4
Catalano, A., Bonuomo, V., Grano, S., Dhupdale, T. S., Bianchi, A., Dansero, L., Gnavi, R., Sacerdote, C., Fava, C., & Ricceri, F. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-25-0969 · Cited by 4
Carter, P., Kitt, L., Rodgers, A., Figg, N. L., Zhou, A., Zhu, C., Wang, Z., Libby, P., Burgess, S., Vassiliou, G. S., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.200334 · Cited by 5
Detection and Characterization of Clonal Hematopoiesis
Locher, B. N., Löwe, P., Christen, F., & Damm, F. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4188-0_20 · Cited by 6
Self-citationBarabino, S. M. L., Citterio, E., & Ronchi, A. E. (2021) · Cancers · doi:10.3390/cancers13153753 · Cited by 4
Chen, R., Ip, P. P., Shaw, J.-J., Wang, Y., Fan, L., Shen, Y., Joseph, N. A., Chen, T.-E., & Chen, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315192 · Cited by 4
Dynamics of clonal hematopoiesis and risk of hematologic malignancy
Arends, C. M., & Jaiswal, S. (2024) · International Journal of Hematology · doi:10.1007/s12185-024-03829-6 · Cited by 4
Self-citationDynamic Clonal Hematopoiesis and Functional T-cell Immunity in a Super-centenarianPreprint
van den Akker, E. B., Makrodimitris, S., Hulsman, M., Brugman, M. H., Nikolic, T., Bradley, T., Waisfisz, Q., Baas, F., Jakobs, M. E., de Jong, D., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/788752 · Cited by 4
Single-cell genomics-based immune and disease monitoring in blood malignancies
Rathgeber, A. C., Ludwig, L. S., & Penter, L. (2024) · Clinical Hematology International · doi:10.46989/001c.117961 · Cited by 4
Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis
Wang, X., Zuo, L., Yu, Y. C., Xiong, X., Xu, J., Qiao, B., Chen, J., Cai, H., Yan, Q., Han, H.-X., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf027 · Cited by 3
Leukemia’s Clonal Evolution in Development, Progression, and Relapse
Loh, J. W., & Khiabanian, H. (2019) · Current Stem Cell Reports · doi:10.1007/s40778-019-00157-y · Cited by 3
COVID-19 and its impact on cancer, HIV, and mentally ill patients
Rasalkar, A. A., Bhatia, S., Katte, T. V., Narayanan, P., Vinjamuri, S., Shettihalli, A. K., Kabade, S., Manas, R. N., Kadappa, V., & Reddy, D. N. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99878-9.00006-6 · Cited by 2
Enhanced Kat3A/Catenin transcription: a common mechanism of therapeutic resistance
Bild, A. H., Teo, J.-L., & Kahn, M. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.32 · Cited by 2
A Vicious Circle of Clonal Haematopoiesis of Indeterminate Potential and Cardiovascular Disease
Ehlert, C. A., & Hilgendorf, I. (2021) · Hämostaseologie · doi:10.1055/a-1576-4059 · Cited by 1
Magyar, E., Újfalusi, A., Czenke, M., & Méhes, G. (2024) · Orvosi Hetilap · doi:10.1556/650.2024.33055 · Cited by 1
Naddaf, L., & Li, S. (2025) · Aging and Cancer · doi:10.1002/aac2.12078 · Cited by 1
Liang, C., Li, M., & Sun, Z. (2025) · Medicine · doi:10.1097/md.0000000000046608 · Cited by 1
Jann, J.-C., Nolte, F., Mossner, M., Flach, J., Altrock, E., Schmitt, N., Röhl, H., Jawhar, A., Neumann, U., Nowak, V., et al. (2019) · Leukemia Research · doi:10.1016/j.leukres.2019.05.005 · Cited by 1
Husby, S., Favero, F., Rodríguez-González, F. G., Sutton, L. A., Haastrup, E. K., Ørskov, A. D., Hansen, J. W., Arboe, B., Aslan, D., Clasen‐Linde, E., et al. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1933473 · Cited by 1
Klonale Hämatopoese – Ursachen und klinische Implikationen
Burchert, A. (2023) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-023-02162-7 · Cited by 1
Clonal hematopoiesis as the intersection between genetics and resilience in Alzheimer’s disease
López-de-Mesa-Aragón, J., Silva‐Buriticá, C., & Salazar‐Londoño, S. (2025) · npj Dementia · doi:10.1038/s44400-025-00014-2 · Cited by 1
Relevance of Clonal Hematopoiesis in Immune Cells for Degenerative Aortic Valve Stenosis
Mas‐Peiró, S., Dimmeler, S., & Zeiher, A. M. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.044406 · Cited by 1
Ahn, J., Kim, T. P., Kim, Y., Cho, Y.-C., Cho, S., Jung, S., Ahn, S., Jung, S.-Y., Yang, D., Lee, J., et al. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.06.001 · Cited by 1
Self-citationKlonale Hämatopoese und solide Neoplasien
Arends, C. M., & Damm, F. (2022) · Die Innere Medizin · doi:10.1007/s00108-022-01404-x · Cited by 1
Self-citationSomatic TET2 Mutations are Associated with Giant Cell ArteritisPreprint
Robinette, M. L., Weeks, L. D., Kramer, R. J., Agrawal, M., Gibson, C. J., Yu, Z., Sekar, A., Mehta, A., Niroula, A., Brown, J. T., et al. (2023) · medRxiv · doi:10.1101/2023.07.26.23292945 · Cited by 1
Kopp, K., Silva, P., Damm, F., & Cosma, N. C. (2026) · Biomedicines · doi:10.3390/biomedicines14051012
Self-citationA CHIP mutation to battle cancer: potential or hazard for cardiovascular disease?
Leuschner, F. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy237
Applied Genomics and Public Health Cancer Genomics
Porcu, P., Kumar, G., Chakravarti, N., Arora, N., Mishra, A., Binder, A., Ertel, A., & Fortina, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813695-9.00004-2
Physiologic and pathologic profiling of clonal variations
Wong, W. (2019) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/scfg-zs49
[Clonal evolution of myelodysplastic syndrome].
Luo, B., Dong, F., & Ema, H. (2019) · PubMed · doi:10.3760/cma.j.issn.0253-2727.2019.12.021
Genomic Landscape and Clonal Evolution of AML
Noerenberg, D., Damm, F., & Bullinger, L. (2021) · Hematologic malignancies · doi:10.1007/978-3-030-72676-8_5
Self-citationFranco, O. A., & Morales, N. O. (2021) · Revista Colombiana de Cancerología · doi:10.35509/01239015.726
Kaufman, D. S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737215426.793570098
Klonale Hämatopoese – Verbindungsglied kardiovaskulärer und hämatologischer Erkrankungen
Frick, M., & Damm, F. (2022) · Transfusionsmedizin · doi:10.1055/a-1720-8217
Self-citationKlonale Hämatopoese – Ursachen und klinische Implikationen
Burchert, A. (2022) · Die Innere Medizin · doi:10.1007/s00108-022-01388-8
Cellular distribution of IDH mutations in AML during morphologic remission
Ramanan, R., Tiong, I. S., Ivey, A., Ong, D. M., Brown, F. C., Chua, C. C., Das, T., & Curtis, D. J. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106993
Klonale Hämatopoese und solide Neoplasien
Arends, C. M., & Damm, F. (2023) · Wiener klinisches Magazin · doi:10.1007/s00740-022-00472-x
Self-citationSpitzer, B. G., Rutherford, K. D., Gundem, G., McGovern, E. M., Millard, N. E., Ossa, J. A., Cheung, I. Y., Gao, T., Levine, M. F., Zhang, Y., et al. (2023) · doi:10.1158/1078-0432.c.6530798
Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms
Xie, Z., Chen, E. C., Mendez, L., Komrokji, R. S., & Zeidan, A. M. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000656
Treiber, H., Ganster, C., Schanz, J., Shimono, J., Zechel, S., Pohanyar, N., Riedel, C. H., Stadelmann, C., Haase, D. T., Trümper, L. H. P., et al. (2023) · Annals of Hematology · doi:10.1007/s00277-023-05430-z
Dederichs, T.-S., Yerdenova, A., Horstmann, H., Vico, T. A., Nübling, S., Peyronnet, R., Mühlen, C. V. Z., Heidt, T., Wolf, D., Westermann, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.11.557290
Clonal Hematopoiesis and Its Functional Implications in MDS/AML
Gill, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-3810-0_28
The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases
Zhang, Z., & Sun, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_5
Mutant macrophages CHIP in to help solid tumors
Tengesdal, I. W., & Jaiswal, S. (2025) · Cell · doi:10.1016/j.cell.2025.03.049
Bone marrow vacuolization to curative strategies: Evolving paradigms in VEXAS syndrome management
Elbadry, M. I., & Mabed, M. (2025) · Current Research in Translational Medicine · doi:10.1016/j.retram.2025.103533
Halik, A., Tilgner, M., Silva, P., Estrada, N., Altwasser, R., Jahn, E., Heuser, M., Hou, H.-A., Pratcorona, M., Hills, R. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787178
Self-citationHalik, A., Tilgner, M., Silva, P., Estrada, N., Altwasser, R., Jahn, E., Heuser, M., Hou, H.-A., Pratcorona, M., Hills, R. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787181
Self-citationClonal hematopoiesis is associated with future diseases and mortality
Liu, W., Deng, Y., Yang, L., Wang, Z., Ma, L., Xu, Y., Dong, Q., Feng, J., Cheng, W., & Yu, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003782
Berg, N. K., Kerchberger, V. E., Pershad, Y., Corty, R. W., Bick, A. G., & Ware, L. B. (2026) · medRxiv · doi:10.64898/2026.04.14.26350864
Park, J. J., Avigan, Z. M., Dong, M. B., Nguyen, C. V., Guitart, J., Kotecha, R., Perica, K., Parekh, S., & Aleman, A. (2026) · Blood neoplasia · doi:10.1016/j.bneo.2026.100244
Hematopoietic somatic mutations in atherosclerotic cardiovascular disease
Ramos-Neble, B. L., & Fuster, J. J. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120718
Pandey, S. N., Afzal, M., Rekha, A., Vijayan, M. P., Uniyal, P., Maji, C., Khan, A., Thangavelu, L., & Nagaraj, K. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112212
Chen, J., Wu, X.-Y., Li, X., Shi, Q., Fu, D., Kao, Y.-R., Zhu, Y., Wang, B.-E., Bian, H.-X., Zhao, Y., et al. (2026) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-25-0191
Streck, E., Harloff, M., Freuer, D., Dintner, S., Dedegkikas, D., Jost, D., Kling, E., Märkl, B., Trepel, M., Hyhlik-Dürr, A., et al. (2026) · JVS Vascular Science · doi:10.1016/j.jvssci.2026.100442
Somatic Blood Mosaicism and Psychiatric Disease: Current Evidence and Causal Limits
Belbe, A.-A., Pîrlog, L.-M., Pilatec, A.-N., Militaru, M.-S., Iordănescu, I. I., & Cătană, A. (2026) · Genes · doi:10.3390/genes17101224
Metadata
- Authors
- Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jäger, M., Yoshida, K., Seemann, R., Noerenberg, D., Waldhueter, N., Fleischer-Notter, H., Christen, F., Schmitt, C. A., Dörken, B., Pelzer, U., Sinn, M., Zemojtel, T., Ogawa, S., Märdian, S., Schreiber, A., Kunitz, A., Krüger, U., Bullinger, L., Mylonas, E., Frick, M., & Damm, F.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Kyoto University (JP)
- Max Delbrück Center (DE)
- ORCID
- Venue
- Leukemia
- Published
- 2018-03-01
- Volume
- 32
- Issue
- 9
- Pages
- 1908-1919
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2789900003
- Cited by
- 194
- References
- 50
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 25 · 2023: 26 · 2022: 31 · 2021: 30 · 2020: 20 · 2019: 27 · 2018: 6
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- clonal hematopoiesis of indeterminate potential, clonal hematopoiesis, variant allele frequency, DNMT3A, hematopoietic stem cells, chemotherapy, hematologic cancer, red blood cell transfusion
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alleles, Cell Differentiation, DNA Mutational Analysis, Female, Gene Frequency, Hematopoiesis, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Mutation, Biomarkers, Immunophenotyping, Polymorphism, Single Nucleotide, Clonal Evolution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
