Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis

The Sequence Alignment/Map format and SAMtools

Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455

Integrative genomics viewer

Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160

Circos: An information aesthetic for comparative genomicsPreprint

Krzywinski, M. I., Schein, J. E., Birol, İ., Connors, J. M., Gascoyne, R. D., Horsman, D. E., Jones, S. J. M., & Marra, M. A. (2009) · Genome Research · doi:10.1101/gr.092759.109 · Cited by 11,073

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049

Aligning sequence reads, clone sequences and assembly con*gs with BWA-MEMPreprint

Li, H. (2014) · arXiv (Cornell University) · doi:10.6084/m9.figshare.963153.v1 · Cited by 5,155

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencingPreprint

Koboldt, D. C., Zhang, Q., Larson, D. E., Shen, D., McLellan, M. D., Lin, L., Miller, C. A., Mardis, E. R., Ding, L., & Wilson, R. K. (2012) · Genome Research · doi:10.1101/gr.129684.111 · Cited by 4,954

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science · doi:10.1126/science.aax3649 · Cited by 441

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

Caiado, F., Pietras, E. M., & Manz, M. G. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201541 · Cited by 289

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Chen, J., Kao, Y.-R., Sun, D., Todorova, T. I., Reynolds, D. M., Narayanagari, S.-R., Montagna, C., Will, B., Verma, A. K., & Steidl, U. G. (2018) · Nature Medicine · doi:10.1038/s41591-018-0267-4 · Cited by 239

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation

Mas‐Peiró, S., Hoffmann, J., Fichtlscherer, S., Dorsheimer, L., Rieger, M. A., Dimmeler, S., Vasa‐Nicotera, M., & Zeiher, A. M. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz591 · Cited by 248

Role of donor clonal hematopoiesis in allogeneic hematopoietic stem-cell transplantation

Frick, M., Chan, W., Arends, C. M., Hablesreiter, R., Halik, A., Heuser, M., Michonneau, D., Blau, O., Hoyer, K., Christen, F., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2018.79.2184 · Cited by 223

TET2-loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity

Fuster, J. J., Zuriaga, M. A., Zorita, V., MacLauchlan, S., Polackal, M. N., Viana-Huete, V., Ferrer-Pérez, A., Matesanz, N., Herrero-Cervera, A., Sano, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108326 · Cited by 204

Clonal hematopoiesis and non-hematologic disorders

Jaiswal, S. (2020) · Blood · doi:10.1182/blood.2019000989 · Cited by 182

JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

Sano, S., Wang, Y., Yura, Y., Sano, M., Oshima, K., Yang, Y., Katanasaka, Y., Min, K.-D., Matsuura, S., Ravid, K., et al. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.013 · Cited by 170

Clonal haematopoiesis and dysregulation of the immune system

Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells

Carlsten, M., & Järås, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02357 · Cited by 156

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Cook, E. K., Izukawa, T., Young, S., Rosen, G., Jamali, M., Zhang, L., Johnson, D., Bain, E., Hilland, J., Ferrone, C. K., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018024729 · Cited by 153

Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

Christen, F., Hoyer, K., Yoshida, K., Hou, H., Waldhüter, N., Heuser, M., Hills, R. K., Chan, W., Hablesreiter, R., Blau, O., et al. (2019) · Blood · doi:10.1182/blood-2018-05-852822 · Cited by 144

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam, A. S., Dusaj, N., Izzo, F., Murali, R., Myers, R. M., Mouhieddine, T. H., Sotelo, J., Benbarche, S., Waarts, M., Gaiti, F., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01179-9 · Cited by 140

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

Zhang, C. R. C., Nix, D., Gregory, M., Ciorba, M. A., Ostrander, E. L., Newberry, R. D., Spencer, D. H., & Challen, G. A. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.11.008 · Cited by 137

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Rahmig, S., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.05.010 · Cited by 130

Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity

Cook, E. K., Luo, M., & Rauh, M. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.011 · Cited by 124

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

Gu, X., Ebrahem, Q., Mahfouz, R. Z., Hasipek, M., Enane, F. O., Radivoyevitch, T., Rapin, N., Przychodzen, B. P., Hu, Z., Balusu, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97117 · Cited by 118

Longitudinal tracking of 97 esophageal adenocarcinomas using liquid biopsy sampling

Ococks, E., Frankell, A. M., Masqué‐Soler, N., Grehan, N., Northrop, A., Coles, H., Redmond, A. M., Devonshire, G., Weaver, J. M. J., Hughes, C. D., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2020.12.010 · Cited by 114

Aging and Hematopoiesis

Groarke, E. M., & Young, N. S. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.03.001 · Cited by 109

Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke

Arends, C. M., Liman, T. G., Strzelecka, P. M., Kufner, A., Löwe, P., Huo, S., Stein, C. M., Piper, S. K., Tilgner, M., Sperber, P. S., et al. (2023) · Blood · doi:10.1182/blood.2022017661 · Cited by 99

Clonal Hematopoiesis and Risk of Incident Lung Cancer

Tian, R., Wiley, B. J., Liu, J., Zong, X., Truong, B. M. T., Zhao, S., Uddin, M. M., Niroula, A., Miller, C. A., Mukherjee, S., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00857 · Cited by 96

Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

Arends, C. M., Weiß, M., Christen, F., Eulenberg-Gustavus, C., Rousselle, A., Kettritz, R., Eckardt, K., Chan, W., Hoyer, K., Frick, M., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.223305 · Cited by 89

Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation

Boettcher, S., Wilk, C. M., Singer, J., Beier, F., Burcklen, E., Beisel, C., Ferreira, M. S. V., Gourri, E., Gassner, C., Frey, B. M., et al. (2020) · Blood · doi:10.1182/blood.2019003079 · Cited by 80

Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease

Ferrone, C. K., Blydt-Hansen, M., & Rauh, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020626 · Cited by 80

Environmental influences on clonal hematopoiesis

King, K. Y., Huang, Y., Nakada, D., & Goodell, M. A. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.12.005 · Cited by 75

Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders

Chavakis, T., Wielockx, B., & Hajishengallis, G. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-052521-013627 · Cited by 75

Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis

Stacey, S., Zink, F., Halldorsson, G. H., Stefánsdóttir, L., Gudjonsson, S. A., Einarsson, G., Hjörleifsson, G., Eiriksdottir, T., Helgadóttir, A., Björnsdóttir, G., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01555-z · Cited by 71

Single-cell analysis based dissection of clonality in myelofibrosis

Mylonas, E., Yoshida, K., Frick, M., Hoyer, K., Christen, F., Kaeda, J., Obenaus, M., Noerenberg, D., Hennch, C., Chan, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13892-x · Cited by 72

Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis

Natarajan, P., Jaiswal, S., & Kathiresan, S. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.118.001926 · Cited by 63

Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities

Hajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 70

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

Lundgren, S., Keränen, M. A. I., Kankainen, M., Huuhtanen, J., Walldin, G., Kerr, C. M., Clemente, M. J., Ebeling, F. T., Rajala, H. L. M., Brück, O. E., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01231-3 · Cited by 63

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation

Ortmann, C. A., Dorsheimer, L., Abou‐El‐Ardat, K., Hoffrichter, J., Aßmus, B., Bonig, H. B., Scholz, A., Pfeifer, H., Martin, H., Schmid, T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.064 · Cited by 61

Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial

Arends, C. M., Dimitriou, S., Stahler, A., Hablesreiter, R., Strzelecka, P. M., Stein, C. M., Tilgner, M., Saiki, R., Ogawa, S., Bullinger, L., et al. (2021) · Blood · doi:10.1182/blood.2021014108 · Cited by 60

Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

Wong, W., Bhatt, S. T., Trinkaus, K. M., Pusic, I., Elliott, K., Mahajan, N., Wan, F., Switzer, G. E., Confer, D. L., DiPersio, J. F., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6249 · Cited by 52

Aggressive Lymphoma after CD19 CAR T-Cell Therapy

Kobbe, G., Brüggemann, M., Baermann, B., Wiegand, L., Trautmann, H., Yousefian, S., Libertini, S., Menssen, H. D., Maier, H. J., Ulrich, P. C., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2402730 · Cited by 60

Developmental and temporal characteristics of clonal sperm mosaicism

Yang, X., Breuss, M. W., Xu, X., Antaki, D., James, K. N., Stanley, V., Ball, L., George, R. D., Wirth, S. A., Cao, B., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.024 · Cited by 55

Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma

Yang, S., Xu, J., Dai, Y., Jin, S., Sun, Y., Li, J., Liu, C.-L., Ma, X., Zhu, C. H., Chen, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44648-3 · Cited by 54

Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation

Boy, M., Bisio, V., Zhao, L., Guidez, F., Schell, B., Lereclus, E., Henry, G., Villemonteix, J., Rodrigues‐Lima, F., Gagne, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36193-w · Cited by 51

Ageing, immune fitness and cancer

Dolan, M., Libby, K. A., Ringel, A. E., van Galen, P., & McAllister, S. S. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00858-z · Cited by 55

Clonal hematopoiesis and its emerging effects on cellular therapies

Bonin, M. V., Jambor, H. K., Teipel, R., Stölzel, F., Thiede, C., Damm, F., Kroschinsky, F., Schetelig, J., Chavakis, T., & Bornhäuser, M. (2021) · Leukemia · doi:10.1038/s41375-021-01337-8 · Cited by 50

CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression

Liu, X., Sato, N., Shimosato, Y., Wang, T., Denda, T., Chang, Y., Yabushita, T., Fujino, T., Asada, S., Tanaka, Y., et al. (2022) · Cancer Science · doi:10.1111/cas.15294 · Cited by 42

Clonal hematopoiesis: Pre-cancer PLUS

Silver, A. J., & Jaiswal, S. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2018.12.003 · Cited by 46

Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL

Eskelund, C. W., Husby, S., Favero, F., Klausen, T. W., Rodríguez-González, F. G., Kolstad, A., Pedersen, L. B., Räty, R., Geisler, C. H., Jerkeman, M., et al. (2020) · Blood · doi:10.1182/blood.2019003539 · Cited by 45

Clonal dynamics and clinical implications of postremission clonal hematopoiesis in acute myeloid leukemia

Tanaka, T. N., Morita, K., Loghavi, S., Wang, F., Furudate, K., Sasaki, Y., Little, L., Gumbs, C. E., Matthews, J. A., Daver, N. G., et al. (2021) · Blood · doi:10.1182/blood.2020010483 · Cited by 43

Clonal haematopoiesis, ageing and kidney disease

Vlasschaert, C., Lanktree, M. B., Rauh, M. J., Kelly, T. N., & Natarajan, P. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00778-x · Cited by 42

Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation

Heimlich, J. B., Bhat, P. K., Parker, A., Jenkins, M. T., Vlasschaert, C., Ulloa, J., Amburg, J. C. V., Potts, C. R., Olson, S., Silver, A. J., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023011445 · Cited by 50

Full Spectrum of Clonal Haematopoiesis-Driver Mutations in Chronic Heart Failure and their Associations with Mortality

Kiefer, K. C., Cremer, S., Pardali, E., Aßmus, B., Abou‐El‐Ardat, K., Kirschbaum, K., Dorsheimer, L., Rasper, T., Berkowitsch, A., Serve, H. L., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13297 · Cited by 46

Clonal hematopoiesis: Molecular and clinical implications

Kusne, Y. N., Xie, Z., & Patnaik, M. M. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106787 · Cited by 43

Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti-CD19 CAR T-cell Treated Patients

Panagiota, V., Kerschbaum, J. F., Penack, O., Stein, C. M., Arends, C. M., Koenecke, C., Strzelecka, P. M., Kloos, A., Wiegand, L., Lasch, A., et al. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000957 · Cited by 44

Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche

Winter, S., Götze, K. S. S., Hecker, J. S., Metzeler, K. H., Guezguez, B., Woods, K., Medyouf, H., Schäffer, A., Schmitz, M., Wehner, R., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02226-6 · Cited by 46

Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer

Arends, C. M., Kopp, K., Hablesreiter, R., Estrada, N., Christen, F., Moll, U. M., Zeillinger, R., Schmitt, W., Sehouli, J., Kulbe, H., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02253-3 · Cited by 45

Clonal hematopoiesis and preleukemia—Genetics, biology, and clinical implications

Hartmann, L., & Metzeler, K. H. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22756 · Cited by 42

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Shin, T., Zhou, Y., Chen, S., Cordes, S., Grice, M. Z., Fan, X., Lee, B., Aljanahi, A. A., Hong, S. G., Vaughan, K. L., et al. (2022) · Blood · doi:10.1182/blood.2021014875 · Cited by 39

Stem cell donors should not be screened for clonal hematopoiesis

Gibson, C. J., & Lindsley, R. C. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000395 · Cited by 33

Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)Preprint

Mitchell, K., & Steidl, U. G. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036251 · Cited by 37

Clonal hematopoiesis and VEXAS syndrome: survival of the fittest clones?

Kusne, Y. N., Fernandez, J. A., & Patnaik, M. M. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.10.004 · Cited by 34

How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies

Wu, D., Luo, X., Feurstein, S. K., Kesserwan, C. A., Mohan, S., Álvarez, D. E. P., & Godley, L. A. (2020) · Haematologica · doi:10.3324/haematol.2018.214221 · Cited by 33

Engrafted Donor-Derived Clonal Hematopoiesis after Allogenic Hematopoietic Cell Transplantation is Associated with Chronic Graft-versus-Host Disease Requiring Immunosuppressive Therapy, but no Adverse Impact on Overall Survival or Relapse

Newell, L. F., Williams, T. P., Liu, J., Yu, Y., Chen, Y., Booth, G. C., Knight, R. J., Goslee, K., Cook, R. J., Leonard, J. T., et al. (2021) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2021.04.014 · Cited by 32

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Papa, V., Marracino, L., Fortini, F., Rizzo, P., Campo, G. C., Vaccarezza, M., & Sega, F. V. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082480 · Cited by 29

Association of Somatic TET2 Mutations With Giant Cell Arteritis

Robinette, M. L., Weeks, L. D., Kramer, R. J., Agrawal, M., Gibson, C. J., Yu, Z., Sekar, A., Mehta, A., Niroula, A., Brown, J. T., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42738 · Cited by 29

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial

Hoyer, K., Hablesreiter, R., Inoue, Y., Yoshida, K., Briest, F., Christen, F., Kakiuchi, N., Yoshizato, T., Shiozawa, Y., Shiraishi, Y., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103327 · Cited by 26

Aged healthy mice acquire clonal hematopoiesis mutations

Chin, D. W. L., Yoshizato, T., Culleton, S. V., Grasso, F., Barbachowska, M., Ogawa, S., Jacobsen, S. E. W., & Woll, P. S. (2021) · Blood · doi:10.1182/blood.2021014235 · Cited by 27

Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta‐analysis

Nowakowska, M. K., Kim, T., Thompson, M. T., Bolton, K. L., Deswal, A., Lin, S. H., Scheet, P. A., Wehner, M. R., & Nead, K. T. (2022) · American Journal of Hematology · doi:10.1002/ajh.26465 · Cited by 28

Clonal Hematopoiesis and therapy related MDS/AML

Desai, P. M., & Roboz, G. J. (2019) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2019.02.006 · Cited by 28

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers

Krishnan, V., Kim, D. D. H., Hughes, T. P., Branford, S., & Ong, S. T. (2021) · Haematologica · doi:10.3324/haematol.2021.279317 · Cited by 27

Somatic mutations and T-cell clonality in patients with immunodeficiency

Savola, P., Martelius, T., Kankainen, M., Huuhtanen, J., Lundgren, S., Koski, Y., Eldfors, S., Kelkka, T., Keränen, M. A. I., Ellonen, P., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.220889 · Cited by 25

p53 biology and reactivation for improved therapy in MDS and AML

Zawacka‐Pankau, J. (2024) · Biomarker Research · doi:10.1186/s40364-024-00579-9 · Cited by 25

Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals

Truty, R., Rojahn, S., Ouyang, K., Kautzer, C., Kennemer, M. I., Álvarez, D. E. P., Johnson, B. A., Stafford, A., Basel‐Vanagaite, L., Saitta, S. C., et al. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.02.013 · Cited by 28

The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation

Nawas, M. T., Schetelig, J., Damm, F., Levine, R. L., Perales, M., Giralt, S., van den Brink, M. R. M., Arcila, M. E., Zehir, A., Papaemmanuil, E., et al. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100744 · Cited by 23

SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation

Chen, C.-W., Zhang, L., Dutta, R. K., Niroula, A., Miller, P. G., Gibson, C. J., Bick, A. G., Reyes, J. M., Lee, Y.-T., Tovy, A., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.011 · Cited by 28

Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients

Halik, A., Tilgner, M., Silva, P., Estrada, N., Altwasser, R., Jahn, E., Heuser, M., Hou, H., Pratcorona, M., Hills, R. K., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01590-1 · Cited by 25

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Mizumaki, H., Hosomichi, K., Hosokawa, K. T., Yoroidaka, T., Imi, T., Zaimoku, Y., Katagiri, T., Nguyen, M. A. T., Tran, D. C., El‐Badry, M., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.247809 · Cited by 25

Clonal haematopoiesis as a risk factor for therapy‐related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo‐(immuno)therapy

Voso, M. T., Pandzic, T., Falconi, G., Denčić‐Fekete, M., Bellis, E. D., Scarfò, L., Ljungström, V., Iskas, M., Poeta, G. D., Ranghetti, P., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18129 · Cited by 25

Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease

Amorós-Pérez, M., & Fuster, J. J. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.008 · Cited by 24

CHIPing away the progression potential of CHIP: A new reality in the making

Xie, Z., & Zeidan, A. M. (2022) · Blood Reviews · doi:10.1016/j.blre.2022.101001 · Cited by 22

DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells

Lim, J.-Y., Duttke, S. H. C., Baker, T. S., Lee, J., Gambino, K. J., Venturini, N. J., Ho, J., Zheng, S., Fstkchyan, Y. S., Pillai, V., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202733 · Cited by 23

How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation

Wells, C., Robertson, T., Sheth, P. M., & Abraham, S. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32831 · Cited by 22

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01469-x · Cited by 22

From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression

Gurnari, C., Fabiani, E., Falconi, G., Travaglini, S., Ottone, T., Cristiano, A., & Voso, M. T. (2021) · Biology · doi:10.3390/biology10020128 · Cited by 22

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma

Bohl, S., Schmalbrock, L. K., Bauhuf, I., Meyer, T., Dolnik, A., Szyska, M., Blätte, T. J., Knödler, S., Röhner, L., Miller, D., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003541 · Cited by 19

Clonal Hematopoiesis and Liquid Biopsy in Gastrointestinal Cancers

Croitoru, V. M., Cazacu, I. M., Popescu, I., Paul, D., Dima, S., Croitoru, A. E., & Tănase, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.772166 · Cited by 21

Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells

Kandarakov, O. F., & Belyavsky, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217902 · Cited by 22

Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia

Woll, P. S., Yoshizato, T., Hellström‐Lindberg, E., Fioretos, T., Ebert, B. L., & Jacobsen, S. E. W. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13535 · Cited by 15

Compartment-specific mutational landscape of clonal hematopoiesis

Hartmann, L., Hecker, J. S., Rothenberg‐Thurley, M., Rivière, J., Jentzsch, M., Ksienzyk, B., Buck, M. C., van der Garde, M., Fischer, L., Winter, S., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01700-3 · Cited by 19

Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement

Lassalle, F., Duployez, N., Vincent, F., Rauch, A., Denimal, T., Rosa, M., Labreuche, J., Dombrowicz, D., Staels, B., Preudhomme, C., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.04.010 · Cited by 21

Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia

Burns, S. S., & Kapur, R. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.07.008 · Cited by 19

Impact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AML

Murphy, T., Zou, J., Daher-Reyes, G. S., Arruda, A., Gupta, V. K., McNamara, C. J., Minden, M. D., Schimmer, A. D., Sibai, H. A., Yee, K. W. L., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000306 · Cited by 19

Clonal hematopoiesis and vascular disease

Amancherla, K. V., Wells, J. A., & Bick, A. G. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00913-z · Cited by 18

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity

Feldkamp, J. D., Vetter, V. M., Arends, C. M., Lang, T. J. L., Bullinger, L., Damm, F., Demuth, I., & Frick, M. (2022) · Haematologica · doi:10.3324/haematol.2021.280021 · Cited by 18

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Gaulin, C., Kelemen, K., & Yi, C. A. (2022) · Life · doi:10.3390/life12081135 · Cited by 16

Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndromePreprint

Ganesan, S., Murray, R. M., Sotélo, J. A. L., Eton, E. O., Takashima, K., Botella, T., Beattie, K., Indart, A. C., Chraiki, N., Croizier, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.19.594376 · Cited by 18

Nonpreferential but Detrimental Accumulation of Macrophages With Clonal Hematopoiesis-Driver Mutations in Cardiovascular Tissues—Brief Report

Dederichs, T.-S., Yerdenova, A., Horstmann, H., Vico, T. A., Nübling, S., Peyronnet, R., Pfeifer, D., Muehlen, C. V. Z., Heidt, T., Wolf, D., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320183 · Cited by 17

Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)

Kállai, A., Ungvari, A., Csabán, D., Őrfi, Z., Lehoczki, A., Harasztdombi, J., Yabluchanskiy, A., Benyó, Z., Szappanos, Á., Tarantini, S., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01654-1 · Cited by 14

A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease

Li, J., Wang, C., Liu, J., Yu, Y., Liu, Y., Peng, Q., Liu, H., & Guan, X. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06370-5 · Cited by 12

The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome

Savola, P., Bhattacharya, D., & Huuhtanen, J. (2022) · Seminars in Hematology · doi:10.1053/j.seminhematol.2022.07.004 · Cited by 14

Prevalence and characteristics of myeloproliferative neoplasms with concomitant monoclonal gammopathy.

Javorniczky, N., Wehrle, J., Ihorst, G., Hupfer, V., Aumann, K., Pfeifer, D., Niemöller, C., Bleul, S., Pantić, M., Werner, M., et al. (2020) · Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis · doi:10.1016/j.leukres.2020.106454 · Cited by 12

Clonal Hematopoiesis of Indeterminate Potential as a Predictor of Colorectal Cancer Risk: Insights from the UK Biobank Cohort

Liu, Y., Xi, Z., Zhou, J., Ling, F., Zhang, Y., Xie, H., Zheng, J., Xia, B., Feng, H., & Li, Y. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1342 · Cited by 12

Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia

Spitzer, B. G., Rutherford, K. D., Gundem, G., McGovern, E. M., Millard, N. E., Ossa, J. A., Cheung, I. Y., Gao, T., Levine, M. F., Zhang, Y., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-2451 · Cited by 12

Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19

Schenz, J., Rump, K., Siegler, B. H., Hemmerling, I., Rahmel, T., Thon, J. N., Nowak, H., Fischer, D. P., Hafner, A., Tichy, L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968778 · Cited by 12

Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones

Osman, A. E. G., Mencia-Trinchant, N., Saygin, C., Moma, L., Kim, A., Housman, G., Pozsgai, M. J., Sinha, E., Chandra, P., Hassane, D. C., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008521 · Cited by 11

Clonal Hematopoiesis: Cell of Origin, Lineage Repartition and Dynamic Evolution during Chemotherapy

Frick, M., Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jäger, M., Yoshida, K., Seemann, R. J., Nörenberg, D., Waldhüter, N., et al. (2017) · Blood · doi:10.1182/blood.v130.suppl_1.632.632 · Cited by 4

New insights into the dynamics of clonal hematopoiesis from targeted sequencing studies

Arends, C. M. (2020) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-28467

Ursprung und Expansion der Klonalen Hämatopoese während der hämatopoetischen Differenzierung

Galan-Sousa, J. (2021) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-29507

Lineage-specific distribution of clonal hematopoiesis of indeterminate potential across mature hematopoietic subpopulations in cancer patients

González, A. P., Jou, C. P., Acha, P., Salvador-Corres, I., Garcés, V. N., Palomo, L., Martinez, S. D. P., Zamora, E., Gonzalez, N. S., Baraibar, I., et al. (2025) · Blood · doi:10.1182/blood-2025-4949

Evolution of clonal hematopoiesis

van Zeventer, I. A., de Graaf, A. O., Jansen, J. H., & Huls, G. A. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1444