The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine “storm” and risk factor for damage of hematopoietic stem cells
Open accessAbstract
The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine “storm,” which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells?
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“During the progress of infection, ATP release may result from the NLRP3 inflammasome response to COVID-19 infection (i) after virus spike protein interaction with the virus entry receptor ACE2, (ii) due to elevated level of Ang II observed in infected patients, or (iii) in response to activated ComC mediators [61].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [61]
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2 retracted
Wang, X., Xu, W., Hu, G., Xia, S., Sun, Z., Liu, Z., Xie, Y., Zhang, R., Jiang, S., & Lu, L. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0498-4 · Cited by 175
RetractedWang, X., Xu, W., Hu, G., Xia, S., Sun, Z., Liu, Z., Xie, Y., Zhang, R., Jiang, S., & Lu, L. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0424-9 · Cited by 162
RetractedHoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286 · cited 1×
“Moreover, as reported recently, S protein must be primed by transmembrane protease serine 2 (TMPRSS2) to facilitate interaction with ACE2 and the subsequent fusion of viral and cellular membranes [4].”
BackgroundMAGRO, C. M. J., Mulvey, J. J., Berlin, D., Nuovo, G. J., Salvatore, S., Harp, J., Baxter-Stoltzfus, A., & Laurence, J. C. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.007 · Cited by 2,224 · cited 1×
“lectin (MBL), which binds to SARS-CoV-2 proteins [12].”
BackgroundRenin-angiotensin-aldosterone system inhibitors in patients with Covid-19
Vaduganathan, M., Vardeny, O., Michel, T., McMurray, J. J. V., Pfeffer, M. A., & Solomon, S. D. (2020) · New England Journal of Medicine · doi:10.1056/nejmsr2005760 · Cited by 2,101
COVID-19 in persons with haematological cancers
He, W., Chen, L., Chen, L., Yuan, G., Fang, Y., Chen, W., Wu, D., Liang, B., Lu, X., Ma, Y., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0836-7 · Cited by 462
Recent advances in inflammasome biology
Place, D. E., & Kanneganti, T. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.011 · Cited by 341 · cited 1×
“lung epithelial, kidney, and cardiac cells [1, 7].”
Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A New Challenge
Violi, F., Pastori, D., Cangemi, R., Pignatelli, P., & Loffredo, L. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1710317 · Cited by 238 · cited 1×
“Importantly, activation of the ComC via the MBL–MASP-2 protease complex leads, in parallel, to activation of the coagulation cascade (CoaC), and in patients infected with SARS-CoV-2, activation of coagulation correlates with a worse prognosis [13].”
BackgroundZambidis, E. T., Park, T. S., Yu, W., Tam, A. J., Levine, M. A., Yuan, X., Pryzhkova, M. V., & Péault, B. (2008) · Blood · doi:10.1182/blood-2008-03-144766 · Cited by 196 · cited 8×
“Moreover, since, as we already reported, HSPCs express Nlrp3 inflammasome components, it would be important to observe the long-term effects of SARS-CoV-2 infection on the hematopoietic stem cell compartment.”
BackgroundInfluentialThe Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
Ratajczak, M. Z., Bujko, K., Cymer, M., Thapa, A., Adamiak, M., Ratajczak, J., Abdel-Latif, A. K., & Kucia, M. (2020) · Leukemia · doi:10.1038/s41375-020-0827-8 · Cited by 102 · cited 4×
“the Nlrp3 inflammasome in normal and malignant hematopoiesis [1].”
BackgroundInfluentialSelf-citationTargeting the NLRP3 inflammasome to treat cardiovascular fibrosis
Pinar, A. A., Scott, T., Huuskes, B. M., Cáceres, F. T., Kemp‐Harper, B. K., & Samuel, C. S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107511 · Cited by 98
Zhao, M., Bai, M., Ding, G., Zhang, Y., Huang, S., Jia, Z., & Zhang, A. (2018) · Kidney Diseases · doi:10.1159/000488242 · Cited by 74
Rodgers, K. E., Xiong, S., & diZerega, G. S. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-002-0509-4 · Cited by 70
Sun, N.-N., Yu, C., Pan, M., Zhang, Y., Zheng, B., Yang, Q., Zheng, Z., & Meng, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-13305-3 · Cited by 59
A role for the renin-angiotensin system in hematopoiesis
Park, T. S., & Zambidis, E. T. (2009) · Haematologica · doi:10.3324/haematol.2009.006965 · Cited by 57 · cited 8×
“Moreover, since, as we already reported, HSPCs express Nlrp3 inflammasome components, it would be important to observe the long-term effects of SARS-CoV-2 infection on the hematopoietic stem cell compartment.”
BackgroundInfluentialEHA Infectious Disease Scientific Working Group, von Lilienfeld-Toal, M., Vehreschild, J. J., Cornely, O., Pagano, L., Compagno, F., & Hirsch, H. H. (2020) · Leukemia · doi:10.1038/s41375-020-0832-y · Cited by 55
Cited by
Sorted by citations
Role of pyroptosis in inflammation and cancer
Xiang, W. D., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J. S., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 728
“Furthermore, activation of the renin–angiotensin–aldosterone system (RAAS) causes increased angiotensin II, which combines with the AT1 receptor to activate the NLRP3 inflammasome in kidney, lung, cardiomyocyte, and hematopoietic cells infected by SARS-CoV-2, all of which drives the maturation of downstream caspase-1,…”
BackgroundZhu, H., Jian, Z., Zhong, Y., Ye, Y., Zhang, Y., Hu, X., Pu, B., Gu, L., & Xiong, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714943 · Cited by 372
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
Tian, M., Liu, W., Li, X., Zhao, P., Shereen, M. A., Zhu, C., Huang, S., Liu, S., Yu, X., Yue, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00726-w · Cited by 249
“The infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19) and has prevalence by affecting billions of people around the world.1,2 Cytokine storm was reported as the main feature in the severity of COVID-19.”
BackgroundInfluentialFluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19
Sukhatme, V. P., Reiersen, A. M., Vayttaden, S. J., & Sukhatme, V. V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.652688 · Cited by 193
Ratajczak, M. Z., Bujko, K., Ciechanowicz, A. K., Sielatycka, K., Cymer, M., Marlicz, W. M., & Kucia, M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10010-z · Cited by 175
“Based on the aforementioned, SARS-CoV-2 may enter and damage cells that express ACE2 entry receptor or damage them by hyper-activation of the Ang II–AT1R axis [21], which may lead to excessive Nlrp3 signaling and pyroptosis [22, 23].”
BackgroundSelf-citation
Metadata
- Authors
- Ratajczak, M. Z., & Kucia, M.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Ratajczak, Mariusz Z.
- Venue
- Leukemia
- Published
- 2020-06-01
- Volume
- 34
- Issue
- 7
- Pages
- 1726-1729
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC7262681
- OpenAlex
- W3031438965
- Semantic Scholar
- 21891a793cf57a44dca049798218b329c5014a35
- Cited by
- 235
- References
- 16
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 26 · 2023: 26 · 2022: 57 · 2021: 69 · 2020: 33
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Leukemia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (2R01 DK074720)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- SARS-CoV-2, NLRP3 inflammasome, cytokine storm, hematopoietic stem cells, COVID-19 pathogenesis, myocarditis, kidney injury, viral entry receptor
- MeSH terms
- Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Betacoronavirus, Cytokine Release Syndrome, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Furans, Gene Expression Regulation, Hematopoietic Stem Cells, Heterocyclic Compounds, 4 or More Rings, Humans, Immunity, Innate, Immunologic Factors, Indenes, Peptidyl-Dipeptidase A, Myocarditis, Pneumonia, Viral, Risk Factors, Sulfonamides, Sulfones, T-Lymphocytes, Cytokines, Coronavirus Infections, Severe Acute Respiratory Syndrome, Acute Kidney Injury, Inflammasomes, Pandemics, Spike Glycoprotein, Coronavirus
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