COVID-19 in persons with haematological cancers
Open accessAbstract
Infection with SARS-CoV-2, the cause of coronavirus infectious disease-19 (COVID-19), has caused a pandemic with >850,000 cases worldwide and increasing. Several studies report outcomes of COVID-19 in predominately well persons. There are also some data on COVID-19 in persons with predominately solid cancer but controversy whether these persons have the same outcomes. We conducted a cohort study at two centres in Wuhan, China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19. We also studied 226 health care providers, 16 of whom developed COVID-19 and 11 of whom were hospitalised. Co-variates were compared with the 115 subjects with haematological cancers without COVID-19 and with 11 hospitalised health care providers with COVID-19. There were no significant differences in baseline co-variates between subjects with haematological cancers developing or not developing COVID-19. Case rates for COVID-19 in hospitalised subjects with haematological cancers was 10% (95% Confidence Interval [CI], 6, 17%) compared with 7% (4, 12%; P = 0.322) in health care providers. However, the 13 subjects with haematological cancers had more severe COVID-19 and more deaths compared with hospitalised health care providers with COVID-19. Case fatality rates were 62% (32, 85%) and 0 (0, 32%; P = 0.002). Hospitalised persons with haematological cancers have a similar case rate of COVID-19 compared with normal health care providers but have more severe disease and a higher case fatality rate. Because we were unable to identify specific risk factors for COVID-19 in hospitalised persons with haematological cancers, we suggest increased surveillance and possible protective isolation.
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Oncology patients are at high risk of contracting COVID-19 and suffering its complications, making prevention of acute healthcare utilization increasingly important during the pandemic.
“Due to the high risk for contracting and suffering complications of COVID-19 among oncology patients, prevention of acute healthcare utilization, such as emergency room (ER) visits and hospitalizations, is increasingly important during the COVID-19 pandemic [1, 2].”
From Risk stratification and outreach to hematology/oncology patients during the COVID-19 pandemic (2021) · cites this paper as [2]
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“Due to the high risk for contracting and suffering complications of COVID-19 among oncology patients, prevention of acute healthcare utilization, such as emergency room (ER) visits and hospitalizations, is increasingly important during the COVID-19 pandemic [1, 2].”
Background
- Authors
- He, W., Chen, L., Chen, L., Yuan, G., Fang, Y., Chen, W., Wu, D., Liang, B., Lu, X., Ma, Y., Li, L., Wang, H., Chen, Z., Li, Q., & Gale, R. P.
- Affiliations
- Wuhan Union Hospital (CN)
- Hubei University of Arts and Science (CN)
- Jinyintan Hospital (CN)
- Central Hospital of Wuhan (CN)
- Imperial College London (GB)
- Corresponding author
- Chen, Li
- Wang, Hongxiang
- Chen, Zhichao
- Li, Qiubai
- ORCID
- Venue
- Leukemia
- Published
- 2020-04-24
- Volume
- 34
- Issue
- 6
- Pages
- 1637-1645
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC7180672
- OpenAlex
- W3019820338
- Cited by
- 462
- References
- 28
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 27 · 2023: 45 · 2022: 79 · 2021: 137 · 2020: 157
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Leukemia (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81974221, 81974009)
- Fundamental Research Funds for the Central Universities
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- COVID-19 pandemic, SARS-CoV-2, hematologic cancer, hospitalized patients, healthcare workers, case fatality rate, disease severity, risk factors, protective isolation, Wuhan
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, China, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Cohort Studies, Incidence, Infectious Disease Transmission, Patient-to-Professional, Coronavirus Infections, Hematologic Neoplasms, Young Adult, Pandemics
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